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Artikel ; Online: Alzheimer's-related brain damage shows sex-specific links with risk factors.

Beckett, Laurel A

2022 Band 20, Heft 12, Seite(n) e3001905

Abstract: Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and ... ...

Abstract	Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and protective factors.
Mesh-Begriff(e)	Female ; Humans ; Male ; Alzheimer Disease/etiology ; tau Proteins/metabolism ; Sex Characteristics ; Alleles ; Brain/metabolism ; Brain Injuries ; Apolipoproteins E ; Risk Factors
Chemische Substanzen	tau Proteins ; Apolipoproteins E
Sprache	Englisch
Erscheinungsdatum	2022-12-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Comment
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001905
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Stroke prevention: An uphill battle.

Beckett, Laurel A / Berglund, Lars F

Neurology

2019 Band 93, Heft 23, Seite(n) 987–988

Mesh-Begriff(e)	Cohort Studies ; Humans ; Stroke
Sprache	Englisch
Erscheinungsdatum	2019-10-31
Erscheinungsland	United States
Dokumenttyp	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000008566
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease.

Wang, Hsin-Pei / Scalco, Rebeca / Saito, Naomi / Beckett, Laurel / Nguyen, My-Le / Huie, Emily Z / Honig, Lawrence S / DeCarli, Charles / Rissman, Robert A / Teich, Andrew F / Mungas, Dan M / Jin, Lee-Way / Dugger, Brittany N

Acta neuropathologica communications

2024 Band 12, Heft 1, Seite(n) 81

Abstract: Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrepresented ... ...

Abstract	Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrepresented ethnic groups. In this cohort study, we evaluated small vessel disease pathologies and α-synuclein deposits among Hispanic decedents (HD, n = 92) and non-Hispanic White decedents (NHWD, n = 184) from three Alzheimer's Disease Research Centers: Columbia University, University of California San Diego, and University of California Davis. The study included cases with a pathological diagnosis of Intermediate/High AD based on the National Institute on Aging- Alzheimer's Association (NIA-AA) and/or NIA-Reagan criteria. A 2:1 random comparison sample of NHWD was frequency-balanced and matched with HD by age and sex. An expert blinded to demographics and center origin evaluated arteriolosclerosis, cerebral amyloid angiopathy (CAA), and Lewy bodies/Lewy neurites (LBs/LNs) with a semi-quantitative approach using established criteria. There were many similarities and a few differences among groups. HD showed more severe Vonsattel grading of CAA in the cerebellum (p = 0.04), higher CAA density in the posterior hippocampus and cerebellum (ps = 0.01), and increased LBs/LNs density in the frontal (p = 0.01) and temporal cortices (p = 0.03), as determined by Wilcoxon's test. Ordinal logistic regression adjusting for age, sex, and center confirmed these findings except for LBs/LNs in the temporal cortex. Results indicate HD with AD exhibit greater CAA and α-synuclein burdens in select neuroanatomic regions when compared to age- and sex-matched NHWD with AD. These findings aid in the generalizability of concurrent arteriolosclerosis, CAA, and LBs/LNs topography and severity within the setting of pathologically confirmed AD, particularly in persons of Hispanic descent, showing many similarities and a few differences to those of NHW descent and providing insights into precision medicine approaches.
Mesh-Begriff(e)	Humans ; Alzheimer Disease/pathology ; Alzheimer Disease/ethnology ; Female ; Male ; Aged ; Hispanic or Latino ; Aged, 80 and over ; Cohort Studies ; White People ; Lewy Bodies/pathology ; Cerebral Amyloid Angiopathy/pathology ; Cerebral Amyloid Angiopathy/ethnology ; alpha-Synuclein/metabolism ; Brain/pathology ; Cerebral Small Vessel Diseases/pathology ; Cerebral Small Vessel Diseases/ethnology ; Arteriolosclerosis/pathology
Chemische Substanzen	alpha-Synuclein
Sprache	Englisch
Erscheinungsdatum	2024-05-24
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-024-01773-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Perspectives of emergency department attendees on outcomes of resuscitation efforts: origins and impact on cardiopulmonary resuscitation preference.

Bandolin, Norkamari Shakira / Huang, Weixiao / Beckett, Laurel / Wintemute, Garen

Emergency medicine journal : EMJ

2020 Band 37, Heft 10, Seite(n) 611–616

Abstract: Background: Previous studies have shown that individuals overestimate the success of cardiopulmonary resuscitation (CPR) while underestimating its morbidity. Although perceptions of CPR success affect medical care in the emergency department (ED), no ED- ...

Abstract	Background: Previous studies have shown that individuals overestimate the success of cardiopulmonary resuscitation (CPR) while underestimating its morbidity. Although perceptions of CPR success affect medical care in the emergency department (ED), no ED-based studies have been done. Objective: To survey ED patients and their companions to assess their expectations, hypothesising that variation in information sources, prior exposure to CPR, and healthcare experience would influence predicted CPR success rates. Methods: A survey was carried out of adults (age >18 years) in the ED waiting area of a tertiary care hospital between June and September 2016. An optimism scale was created to reflect expected likelihood of survival after CPR, or CPR success, under several sets of circumstances. Potential predictors of optimism for CPR outcome were examined using linear regression. Associations between optimism and CPR preference were evaluated using a Wilcoxon rank-sum test. Results: There were 500 respondents and 53% had performed or witnessed CPR, and/or participated in a CPR course (64%). Television was the main source of information about CPR for >95% of respondents. At least half (51-64%) of respondents estimated the success rate of CPR as over 75% in all situations. Estimated CPR success rates were unrelated to age, sex, race, spiritual beliefs or personal healthcare experience. More than 90% of respondents wanted to receive CPR. Less than one-third of respondents had discussed CPR with a medical provider, but most wished to do so. Conclusion: Consistent with prior studies, individuals overestimate the success rate of CPR. Healthcare experience does not appear to mitigate optimism about CPR, and individuals overwhelmingly want CPR for themselves. Though few had talked about CPR with a medical provider, most wanted to have informed decision-making conversations. Such discussions could help patients obtain a more realistic view of CPR outcomes.
Mesh-Begriff(e)	Adult ; California ; Cardiopulmonary Resuscitation/methods ; Decision Making ; Emergency Service, Hospital ; Female ; Humans ; Male ; Patient Preference ; Prospective Studies ; Surveys and Questionnaires ; Tertiary Care Centers
Sprache	Englisch
Erscheinungsdatum	2020-07-13
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2018-208084
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Injection-site Reactions to Sustained-release Meloxicam in Sprague-Dawley Rats.

Stewart, Leslie A / Imai, Denise M / Beckett, Laurel / Li, Yueju / Lloyd, K C / Grimsrud, Kristin N

Journal of the American Association for Laboratory Animal Science : JAALAS

2020 Band 59, Heft 6, Seite(n) 726–731

Abstract: An extended-release formulation of the NSAID meloxicam (MSR) is used to provide 72 h of continuous analgesia in many species, including rodents. Although standard formulations of meloxicam are frequently used in rats with no observable injection-site ... ...

Abstract	An extended-release formulation of the NSAID meloxicam (MSR) is used to provide 72 h of continuous analgesia in many species, including rodents. Although standard formulations of meloxicam are frequently used in rats with no observable injection-site reactions, the potential adverse effects from MSR have not been characterized sufficiently nor has a prospective study of these effects been performed in rats. To address this deficiency, we evaluated injection-site reactions after a single subcutaneous administration of MSR (
Mesh-Begriff(e)	Analgesia/methods ; Analgesia/veterinary ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Delayed-Action Preparations/adverse effects ; Female ; Male ; Meloxicam/adverse effects ; Pain/drug therapy ; Prospective Studies ; Rats ; Rats, Sprague-Dawley
Chemische Substanzen	Anti-Inflammatory Agents, Non-Steroidal ; Delayed-Action Preparations ; Meloxicam (VG2QF83CGL)
Sprache	Englisch
Erscheinungsdatum	2020-09-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1559-6109
ISSN	1559-6109
DOI	10.30802/AALAS-JAALAS-20-000014
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A novel gamma GLM approach to MRI relaxometry comparisons.

Kapre, Rohan / Zhou, Junhan / Li, Xinzhe / Beckett, Laurel / Louie, Angelique Y

Magnetic resonance in medicine

2020 Band 84, Heft 3, Seite(n) 1592–1604

Abstract: Purpose: To demonstrate that constant coefficient of variation (CV), but nonconstant absolute variance in MRI relaxometry (T: Methods: Eight models including OLS and GGLM-ID were initially fit to data obtained on sulfated dextran iron oxide (SDIO) ... ...

Abstract	Purpose: To demonstrate that constant coefficient of variation (CV), but nonconstant absolute variance in MRI relaxometry (T Methods: Eight models including OLS and GGLM-ID were initially fit to data obtained on sulfated dextran iron oxide (SDIO) nanoparticles. Both a resampling simulation on the data as well as two separate Monte Carlo simulations (with and without concentration error) were performed to determine mean square error (MSE) and type I error rate. We then evaluated the performance of OLS/GGLM-ID on R Results: OLS had an MSE of 4-5× that of GGLM-ID as well as a type I error rate of 20-30%, whereas GGLM-ID was near the nominal 5% level in the relaxivity study. Only OLS found statistically significant effects of MRI facility on relaxivity in an R Conclusions: OLS leads to erroneous conclusions when analyzing MRI relaxometry data. GGLM-ID factors in the inherent CV of an MRI experiment, leading to more reproducible conclusions.
Mesh-Begriff(e)	Contrast Media ; Humans ; Iron ; Iron Overload ; Liver ; Magnetic Resonance Imaging
Chemische Substanzen	Contrast Media ; Iron (E1UOL152H7)
Sprache	Englisch
Erscheinungsdatum	2020-02-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28192
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ideal Worker and Academic Professional Identity: Perspectives from a Career Flexibility Educational Intervention.

Howell, Lydia Pleotis / Beckett, Laurel A / Villablanca, Amparo C

The American journal of medicine

2017 Band 130, Heft 9, Seite(n) 1117–1125

Mesh-Begriff(e)	Adult ; California ; Career Choice ; Career Mobility ; Faculty, Medical/psychology ; Female ; Humans ; Inservice Training ; Job Satisfaction ; Male ; Middle Aged ; Organizational Culture ; Organizational Policy ; Personal Satisfaction ; Professional Practice ; Surveys and Questionnaires ; Work-Life Balance
Sprache	Englisch
Erscheinungsdatum	2017-06-15
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2017.06.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease.

Scalco, Rebeca / Saito, Naomi / Beckett, Laurel / Nguyen, My-Le / Huie, Emily / Wang, Hsin-Pei / Flaherty, Delaney A / Honig, Lawrence S / DeCarli, Charles / Rissman, Robert A / Teich, Andrew F / Jin, Lee-Way / Dugger, Brittany N

Acta neuropathologica communications

2023 Band 11, Heft 1, Seite(n) 105

Abstract: Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most ... ...

Abstract	Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most autopsy-based studies have focused on cohorts of non-Hispanic White decedents (NHWD), with few studies including Hispanic decedents (HD). We aimed to characterize the neuropathologic landscape of AD in NHWD (n = 185) and HD (n = 92) evaluated in research programs across three institutions: University of California San Diego, University of California Davis, and Columbia University. Only persons with a neuropathologic diagnosis of intermediate/high AD determined by NIA Reagan and/or NIA-AA criteria were included. A frequency-balanced random sample without replacement was drawn from the NHWD group using a 2:1 age and sex matching scheme with HD. Four brain areas were evaluated: posterior hippocampus, frontal, temporal, and parietal cortices. Sections were stained with antibodies against Aβ (4G8) and phosphorylated tau (AT8). We compared the distribution and semi-quantitative densities for neurofibrillary tangles (NFTs), neuropil threads, core, diffuse, and neuritic plaques. All evaluations were conducted by an expert blinded to demographics and group status. Wilcoxon's two-sample test revealed higher levels of neuritic plaques in the frontal cortex (p = 0.02) and neuropil threads (p = 0.02) in HD, and higher levels of cored plaques in the temporal cortex in NHWD (p = 0.02). Results from ordinal logistic regression controlling for age, sex, and site of origin were similar. In other evaluated brain regions, semi-quantitative scores of plaques, tangles, and threads did not differ statistically between groups. Our results demonstrate HD may be disproportionately burdened by AD-related pathologies in select anatomic regions, particularly tau deposits. Further research is warranted to understand the contributions of demographic, genetic, and environmental factors to heterogeneous pathological presentations.
Mesh-Begriff(e)	Humans ; Aged ; Alzheimer Disease ; Plaque, Amyloid ; White ; Neuropathology ; Neurofibrillary Tangles
Sprache	Englisch
Erscheinungsdatum	2023-06-29
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01574-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Relationship between per capita births of Cook Inlet belugas and summer salmon runs: age‐structured population modeling

Norman, Stephanie A / Hobbs, Roderick C / Beckett, Laurel A / Trumble, Stephen J / Smith, Woutrina A

Ecosphere. 2020 Jan., v. 11, no. 1

2020

Abstract: Anthropogenic disturbances may alter a population's conservation status if the ability of individuals to survive and breed is affected. We used an adaptation of the Heligman‐Pollard model to estimate survival at age of Cook Inlet belugas (CIB; ... ...

Abstract	Anthropogenic disturbances may alter a population's conservation status if the ability of individuals to survive and breed is affected. We used an adaptation of the Heligman‐Pollard model to estimate survival at age of Cook Inlet belugas (CIB; Delphinapterus leucas), an endangered population in south‐central Alaska. We developed an age‐structured Leslie matrix model, based on the life history parameters survival and fecundity probability, to evaluate the sensitivity of population size and growth of CIB, to variation in estimate values of Chinook and coho salmon abundance in the Deshka River, a major tributary of the Susitna River. Birth effect (eb) was regressed against Chinook and coho salmon levels for the year of, the year before, and two years before a beluga calf birth. The effect of a range of modifications of salmon availability was illustrated in CIB with a series of simulations. The maximum annual population growths (λ) were set at 1.036 (3.6%). Ranges of CIB survival and fecundity probabilities indicated small changes in survival probabilities have a greater impact on population growth than similar changes in birth probability. As either survival (eₛ) or fecundity (eb) was reduced, the annual growth declined, with either eₛ = 0.961 or eb = 0.388, causing a decreased annual growth of −0.4%. Regressions of Chinook salmon for the year of, the year before, and two years before a birth were all significant at the 5% level as was coho in the year of and year prior to birth. The mechanism model with the best fit was the sum of Chinook and coho in the year of birth and year prior to birth. Simulations showed that if salmon runs remained at their current levels, the CIB population would likely continue its current slow decline and per capita births would continue to be low. The results from this study suggest reproductive success in CIB is tied to salmon abundance in the Deshka River. Current management practices should consider this when setting research priorities, designing new studies, and developing management actions to achieve CIB population recovery targets.
Schlagwörter	Delphinapterus leucas ; Oncorhynchus kisutch ; Oncorhynchus tshawytscha ; age structure ; anthropogenic activities ; calves ; conservation status ; fecundity ; life history ; models ; population growth ; population size ; probability ; reproductive success ; rivers ; salmon ; summer ; Alaska
Sprache	Englisch
Erscheinungsverlauf	2020-01
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel
Anmerkung	JOURNAL ARTICLE
ZDB-ID	2572257-8
ISSN	2150-8925
ISSN	2150-8925
DOI	10.1002/ecs2.2955
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Injection Reactions after Administration of Sustained-release Meloxicam to BALB/cJ, C57BL/6J, and Crl:CD1(ICR) Mice.

Fuetsch, Stephanie R / Stewart, Leslie A / Imai, Denise M / Beckett, Laurel A / Li, Yueju / Lloyd, K C Kent / Grimsrud, Kristin N

Journal of the American Association for Laboratory Animal Science : JAALAS

2021 Band 60, Heft 2, Seite(n) 176–183

Abstract: The sustained-release formulation of meloxicam (MSR) is a compounded NSAID that may provide pain relief for as long as 72 h after administration. MSR injection-site skin reactions have occurred in several species but have not previously been observed in ... ...

Abstract	The sustained-release formulation of meloxicam (MSR) is a compounded NSAID that may provide pain relief for as long as 72 h after administration. MSR injection-site skin reactions have occurred in several species but have not previously been observed in mice. We investigated the development and progression of localized skin reactions after a single injection of MSR in Crl:CD1(ICR), C57BL/6J, and BALB/cJ mice. Each mouse received a subcutaneous injection of MSR (
Mesh-Begriff(e)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Delayed-Action Preparations ; Female ; Injections, Subcutaneous ; Male ; Meloxicam/administration & dosage ; Meloxicam/adverse effects ; Mice ; Mice, Inbred Strains ; Sex Characteristics
Chemische Substanzen	Anti-Inflammatory Agents, Non-Steroidal ; Delayed-Action Preparations ; Meloxicam (VG2QF83CGL)
Sprache	Englisch
Erscheinungsdatum	2021-01-05
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2769-6677
ISSN (online)	2769-6677
DOI	10.30802/AALAS-JAALAS-20-000042
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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