Artikel ; Online: CT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis.
2024 Band 35, Heft 6, Seite(n) 971–996
Abstract: The use of opportunistic computed tomography (CT) image-based biomarkers may be a low-cost strategy for screening older individuals at high risk for osteoporotic fractures and populations that are not sufficiently targeted. This review aimed to assess ... ...
Abstract | The use of opportunistic computed tomography (CT) image-based biomarkers may be a low-cost strategy for screening older individuals at high risk for osteoporotic fractures and populations that are not sufficiently targeted. This review aimed to assess the discriminative ability of image-based biomarkers derived from existing clinical routine CT scans for hip, vertebral, and major osteoporotic fracture prediction. A systematic search in PubMed MEDLINE, Embase, Cochrane, and Web of Science was conducted from the earliest indexing date until July 2023. The evaluation of study quality was carried out using a modified Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2) checklist. The primary outcome of interest was the area under the curve (AUC) and its corresponding 95% confidence intervals (CIs) obtained for four main categories of biomarkers: areal bone mineral density (BMD), image attenuation, volumetric BMD, and finite element (FE)-derived biomarkers. The meta-analyses were performed using random effects models. Sixty-one studies were included in this review, among which 35 were synthesized in a meta-analysis and the remaining articles were qualitatively synthesized. In comparison to the pooled AUC of areal BMD (0.73 [95% CI 0.71-0.75]), the pooled AUC values for predicting osteoporotic fractures for FE-derived parameters (0.77 [95% CI 0.72-0.81]; p < 0.01) and volumetric BMD (0.76 [95% CI 0.71-0.81]; p < 0.01) were significantly higher, but there was no significant difference with the pooled AUC for image attenuation (0.73 [95% CI 0.66-0.79]; p = 0.93). Compared to areal BMD, volumetric BMD and FE-derived parameters may provide a significant improvement in the discrimination of osteoporotic fractures using opportunistic CT assessments. |
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Mesh-Begriff(e) | Humans ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/physiopathology ; Bone Density/physiology ; Tomography, X-Ray Computed/methods ; Biomarkers/blood ; Mass Screening/methods ; Spinal Fractures/physiopathology ; Spinal Fractures/diagnostic imaging ; Hip Fractures/diagnostic imaging ; Hip Fractures/physiopathology ; Finite Element Analysis |
Chemische Substanzen | Biomarkers |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-14 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Systematic Review ; Meta-Analysis ; Review |
ZDB-ID | 1064892-6 |
ISSN | 1433-2965 ; 0937-941X |
ISSN (online) | 1433-2965 |
ISSN | 0937-941X |
DOI | 10.1007/s00198-024-07029-0 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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