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  1. Artikel ; Online: Quantification of rifampicin loaded into inhaled polymeric nanoparticles by reversed phase high-performance liquid chromatography in pulmonary nonphagocytic cellular uptake.

    Romina, Scolari Ivana / Benjamín, De La Cruz-Thea / Mara, Musri Melina / Ester, Granero Gladys

    Analytical methods : advancing methods and applications

    2024  Band 16, Heft 13, Seite(n) 1908–1915

    Abstract: Rifampicin is an antibiotic effective against both Gram-negative and Gram-positive bacteria and is commonly used as a first-line treatment for tuberculosis caused ... ...

    Abstract Rifampicin is an antibiotic effective against both Gram-negative and Gram-positive bacteria and is commonly used as a first-line treatment for tuberculosis caused by
    Mesh-Begriff(e) Humans ; Rifampin/pharmacology ; Rifampin/chemistry ; Chromatography, High Pressure Liquid/methods ; Tuberculosis ; Pharmaceutical Preparations ; Nanoparticles/chemistry ; Lung
    Chemische Substanzen Rifampin (VJT6J7R4TR) ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d4ay00234b
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Exosome-like Vesicles of Giardia Assemblages A, B, and E Are Involved in the Delivering of Distinct Small RNA from Parasite to Parasite

    Lautaro Natali / Gabriel Luna Pizarro / Sofía Moyano / Benjamin de la Cruz-Thea / Juliana Musso / Andrea S. Rópolo / Norbert Eichner / Gunter Meister / Melina M. Musri / Constanza Feliziani / María C. Touz

    International Journal of Molecular Sciences, Vol 24, Iss 9559, p

    2023  Band 9559

    Abstract: The genetically related assemblages of the intestinal protozoa parasite Giardia lamblia are morphologically indistinguishable and are often derived from specific hosts. The Giardia assemblages are separated by large genetic distances, which might account ...

    Abstract The genetically related assemblages of the intestinal protozoa parasite Giardia lamblia are morphologically indistinguishable and are often derived from specific hosts. The Giardia assemblages are separated by large genetic distances, which might account for their relevant biological and pathogenic differences. In this work, we analyzed the RNAs cargo released into exosomal-like vesicles (ElVs) by the assemblages A and B, which differentially infect humans, and the assemblage E, which infects hoofed animals. The RNA sequencing analysis revealed that the ElVs of each assemblage contained distinct small RNA (sRNA) biotypes, suggesting a preference for specific packaging in each assemblage. These sRNAs were classified into three categories, ribosomal-small RNAs (rsRNAs), messenger-small RNAs (msRNAs), and transfer-small RNAs (tsRNAs), which may play a regulatory role in parasite communication and contribute to host-specificity and pathogenesis. Uptake experiments showed, for the first time, that ElVs were successfully internalized by the parasite trophozoites. Furthermore, we observed that the sRNAs contained inside these ElVs were first located below the plasma membrane but then distributed along the cytoplasm. Overall, the study provides new insights into the molecular mechanisms underlying the host-specificity and pathogenesis of G. lamblia and highlights the potential role of sRNAs in parasite communication and regulation.
    Schlagwörter Giardia lamblia ; parasite to parasite communication ; exosomal-like vesicles (ElVs) ; small RNAs (sRNA) ; msRNA ; tsRNA ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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