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  1. Artikel ; Online: Estrogen Receptor-β Agonists Modulate T-Lymphocyte Activation and Ameliorate Left Ventricular Remodeling During Chronic Heart Failure.

    Rosenzweig, Rachel / Kumar, Vinay / Gupta, Sahil / Bermeo-Blanco, Oscar / Stratton, Matthew S / Gumina, Richard J / Bansal, Shyam S

    Circulation. Heart failure

    2022  Band 15, Heft 7, Seite(n) e008997

    Abstract: Background: CD4: Methods: RNA-sequencing of cardiac CD4: Results: RNA-sequencing of CD4: Conclusions: Our studies indicate that ERβ agonists and OSU-ERb-012, in particular, could be used as selective immunomodulatory drugs to inhibit ... ...

    Abstract Background: CD4
    Methods: RNA-sequencing of cardiac CD4
    Results: RNA-sequencing of CD4
    Conclusions: Our studies indicate that ERβ agonists and OSU-ERb-012, in particular, could be used as selective immunomodulatory drugs to inhibit CD4
    Mesh-Begriff(e) Animals ; Chronic Disease ; Estrogen Receptor alpha ; Estrogen Receptor beta/physiology ; Estrogen Receptor beta/therapeutic use ; Estrogens/therapeutic use ; Female ; Heart Failure ; Lymphocyte Activation ; Male ; Mice ; Myocardial Infarction/metabolism ; RNA/therapeutic use ; Receptors, Estrogen/therapeutic use ; Ventricular Remodeling/physiology
    Chemische Substanzen Estrogen Receptor alpha ; Estrogen Receptor beta ; Estrogens ; Receptors, Estrogen ; RNA (63231-63-0)
    Sprache Englisch
    Erscheinungsdatum 2022-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.121.008997
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ectonucleoside triphosphate diphosphohydrolase-1 (CD39) impacts TGF-β1 responses: insights into cardiac fibrosis and function following myocardial infarction.

    Novitskaya, Tatiana / Nishat, Shamama / Covarrubias, Roman / Wheeler, Debra G / Chepurko, Elena / Bermeo-Blanco, Oscar / Xu, Zhaobin / Baer, Bradly / He, Heng / Moore, Stephanie N / Dwyer, Karen M / Cowan, Peter J / Su, Yan Ru / Absi, Tarek S / Schoenecker, Jonathan / Bellan, Leon M / Koch, Walter J / Bansal, Shyam / Feoktistov, Igor /
    Robson, Simon C / Gao, Erhe / Gumina, Richard J

    American journal of physiology. Heart and circulatory physiology

    2022  Band 323, Heft 6, Seite(n) H1244–H1261

    Abstract: Extracellular purine nucleotides and nucleosides released from activated or injured cells influence multiple aspects of cardiac physiology and pathophysiology. Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; CD39) hydrolyzes released ... ...

    Abstract Extracellular purine nucleotides and nucleosides released from activated or injured cells influence multiple aspects of cardiac physiology and pathophysiology. Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; CD39) hydrolyzes released nucleotides and thereby regulates the magnitude and duration of purinergic signaling. However, the impact of CD39 activity on post-myocardial infarction (MI) remodeling is incompletely understood. We measured the levels and activity of ectonucleotidases in human left ventricular samples from control and ischemic cardiomyopathy (ICM) hearts and examined the impact of ablation of
    Mesh-Begriff(e) Humans ; Mice ; Animals ; Transforming Growth Factor beta1/metabolism ; Ventricular Remodeling ; Myocardium/metabolism ; Myocardial Infarction ; Fibrosis ; Fibroblasts/metabolism ; Collagen/metabolism
    Chemische Substanzen Transforming Growth Factor beta1 ; CD39 antigen (EC 3.6.1.5) ; triphosphoric acid (NU43IAG5BC) ; Collagen (9007-34-5)
    Sprache Englisch
    Erscheinungsdatum 2022-10-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00138.2022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Implantation and monitoring of a novel telemetry unit in the Syrian golden hamster model.

    Garver, Jennifer / Bermeo-Blanco, Oscar A / Gibson, Neil / Bogie, Heather / Grenwis, Jessica / Vela, Eric M

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2012  Band 25, Heft 3, Seite(n) 186–196

    Abstract: Radiotelemetry allows for real-time remote monitoring of biological parameters in freely moving laboratory animals. The HD-X11 transmitter is a novel telemetry device that enables simultaneous collection of body temperature, activity, blood pressure, ... ...

    Abstract Radiotelemetry allows for real-time remote monitoring of biological parameters in freely moving laboratory animals. The HD-X11 transmitter is a novel telemetry device that enables simultaneous collection of body temperature, activity, blood pressure, electrocardiogram (ECG), and other biopotentials in small animal models. Previously, researchers could only collect either blood pressure or ECG parameters; prioritizing the signal of most interest or increasing the number of animals on study to capture both signals at one time. This new device eliminates the need for separate animal groups for assorted measurements and allows for a more complete cardiovascular assessment. Evaluation of the transmitter from both surgical and data collection perspectives indicates that the HD-X11 transmitter can be a useful tool to researchers in a wide range of scientific and medical fields.
    Mesh-Begriff(e) Animals ; Blood Pressure ; Body Temperature ; Cricetinae ; Electrocardiography ; Female ; Heart Rate ; Mesocricetus/physiology ; Models, Animal ; Motor Activity ; Telemetry/instrumentation ; Telemetry/statistics & numerical data ; Telemetry/veterinary
    Sprache Englisch
    Erscheinungsdatum 2012-08-07
    Erscheinungsland United States
    Dokumenttyp Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.3109/08941939.2011.616572
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2364: Hefte anzeigen Standort:
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  4. Artikel ; Online: Preservation of auditory brainstem response thresholds after cochleostomy and titanium microactuator implantation in the lateral wall of cat scala tympani.

    Lesinski, S George / Prewitt, Jessica / Bray, Victor / Aravamudhan, Radhika / Bermeo Blanco, Oscar A / Farmer-Fedor, Brenda L / Ward, Jonette A

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2014  Band 35, Heft 4, Seite(n) 730–738

    Abstract: Hypothesis: The safety of implanting a titanium microactuator into the lateral wall of cat scala tympani was assessed by comparing preoperative and postoperative auditory brainstem response (ABR) thresholds for 1 to 3 months.: Background: The safety ... ...

    Abstract Hypothesis: The safety of implanting a titanium microactuator into the lateral wall of cat scala tympani was assessed by comparing preoperative and postoperative auditory brainstem response (ABR) thresholds for 1 to 3 months.
    Background: The safety of directly stimulating cochlear perilymph with an implantable hearing system requires maintaining preoperative hearing levels. This cat study is an essential step in the development of the next generation of fully implantable hearing devices for humans.
    Methods: Following GLP surgical standards, a 1-mm cochleostomy was drilled into the lateral wall of the scala tympani, and a nonfunctioning titanium anchor/microactuator assembly was inserted in 8 cats. The scala media was damaged in the 1 cat. ABR thresholds with click and 4- and 8-kHz stimuli were measured preoperatively and compared with postoperative thresholds at 1, 2, and 3 months. Nonimplanted ear thresholds were also measured to establish statistical significance for threshold shifts (>28.4 dB). Two audiologists independently interpreted thresholds.
    Results: Postoperatively, 7 cats implanted in the scala tympani demonstrated no significant ABR threshold shift for click stimulus; one shifted ABR thresholds to 4- and 8-kHz stimuli. The eighth cat, with surgical damage to the scala media, maintained stable click threshold but had a significant shift to 4- and 8-kHz stimuli.
    Conclusion: This cat study provides no evidence of worsening hearing thresholds after fenestration of the scala tympani and insertion of a titanium anchor/microactuator, provided there is no surgical trauma to the scala media and the implanted device is securely anchored in the cochleostomy. These 2 issues have been resolved in the development of a fully implantable hearing system for humans. The long-term hearing stability (combined with histologic studies) reaffirm that the microactuator is well tolerated by the cat cochlea.
    Mesh-Begriff(e) Acoustic Stimulation ; Anesthesia ; Animals ; Auditory Threshold ; Cats ; Cochlea/surgery ; Cochlear Implantation ; Cochlear Implants ; Evoked Potentials, Auditory, Brain Stem/physiology ; Functional Laterality/physiology ; Male ; Otologic Surgical Procedures ; Scala Tympani/surgery ; Titanium
    Chemische Substanzen Titanium (D1JT611TNE)
    Sprache Englisch
    Erscheinungsdatum 2014-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000000281
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1554: Hefte anzeigen Standort:
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