Artikel ; Online: Cellular responses to extracellular guidance cues.
2010 Band 29, Heft 16, Seite(n) 2734–2745
Abstract: Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substrates, but to act as guidance cues, ... ...
Abstract | Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substrates, but to act as guidance cues, they must be presented to the cell in a spatially restricted manner. Cells that recognize such cues respond by activating intracellular signal transduction pathways in a spatially restricted manner and convert the extracellular information into intracellular polarity. Although extracellular cues influence a broad range of cell polarity decisions, such as mitotic spindle orientation during asymmetric cell division, or the establishment of apical-basal polarity in epithelia, this review will focus specifically on guidance cues that promote cell migration (chemotaxis), or localized cell shape changes (chemotropism). |
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Mesh-Begriff(e) | Animals ; Cell Shape ; Chemotaxis ; Humans ; Signal Transduction |
Sprache | Englisch |
Erscheinungsdatum | 2010-08-18 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 586044-1 |
ISSN | 1460-2075 ; 0261-4189 |
ISSN (online) | 1460-2075 |
ISSN | 0261-4189 |
DOI | 10.1038/emboj.2010.170 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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