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  1. Buch: Hypogonadism

    Bhasin, Shalender

    (Endocrinology and metabolism clinics of North America ; volume 51, number 1 (March 2022))

    2022  

    Verfasserangabe editors Shalender Bhasin, Channa N. Jayasena
    Serientitel Endocrinology and metabolism clinics of North America ; volume 51, number 1 (March 2022)
    Überordnung
    Sprache Englisch
    Umfang xvi, 228 Seiten, Illustrationen
    Verlag Elsevier
    Erscheinungsort Philadelphia, Pennsylvania
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT021318356
    ISBN 978-0-323-89678-8 ; 0-323-89678-2
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Time-Restricted Eating to Improve Health-A Promising Idea in Need of Stronger Clinical Trial Evidence.

    Bhasin, Shalender

    JAMA internal medicine

    2022  Band 182, Heft 9, Seite(n) 963–964

    Mesh-Begriff(e) Eating ; Health Promotion ; Humans
    Sprache Englisch
    Erscheinungsdatum 2022-08-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2022.3038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Testosterone replacement in aging men: an evidence-based patient-centric perspective.

    Bhasin, Shalender

    The Journal of clinical investigation

    2021  Band 131, Heft 4

    Sprache Englisch
    Erscheinungsdatum 2021-06-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI146607
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Prostate Risk and Monitoring During Testosterone Replacement Therapy.

    Bhasin, Shalender / Thompson, Ian M

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Men with hypogonadism have reduced risk of prostate cancer mortality; whether testosterone treatment increases the risk of prostate safety events in men with hypogonadism remains controversial. Several studies including four larger randomized trials-the ... ...

    Abstract Men with hypogonadism have reduced risk of prostate cancer mortality; whether testosterone treatment increases the risk of prostate safety events in men with hypogonadism remains controversial. Several studies including four larger randomized trials-the Testosterone Trials, TEstosterone and Atherosclerosis Progression in Aging Men (TEAAM) Trial, Testosterone for Diabetes Mellitus Trial, and Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE in hypogonadal men (TRAVERSE) Trial-treated men with testosterone or placebo for one year or longer and reported prospectively-ascertained prostate safety data. The TRAVERSE Trial, because of its large size, longer duration, and adjudication of prostate events, has provided comprehensive data on the risk of adverse prostate events during TRT. Among men with hypogonadism, carefully screened to exclude those at high risk of prostate cancer, the incidences of high-grade or any prostate cancer, acute urinary retention, surgical procedure for benign prostatic hyperplasia, prostate biopsy, or new pharmacologic therapy for lower urinary tract symptoms were low and did not differ between the testosterone and placebo groups. Testosterone did not worsen lower urinary tract symptoms. TRT was associated with a greater increase in PSA than placebo in the first year of treatment. Conclusions: Testosterone treatment of men with hypogonadism, screened to exclude those at high risk of prostate cancer, is associated with low risk of adverse prostate events. Baseline evaluation of prostate cancer risk and a standardized monitoring plan can minimize the risk of unnecessary prostate biopsy while enabling the detection of high-grade prostate cancers in men receiving TRT.
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae334
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Rectal foreign body removal: increasing incidence and cost to the NHS.

    Bhasin, S / Williams, J G

    Annals of the Royal College of Surgeons of England

    2021  Band 103, Heft 10, Seite(n) 734–737

    Abstract: Introduction: Insertion of foreign objects into the rectum is a well-described phenomenon and not an uncommon referral to the general surgeon on call. Although usually not life-threatening, there can be consequences following migration of the object or ... ...

    Abstract Introduction: Insertion of foreign objects into the rectum is a well-described phenomenon and not an uncommon referral to the general surgeon on call. Although usually not life-threatening, there can be consequences following migration of the object or perforation of the large bowel. This study looks at the incidence of removal of foreign objects from the rectum over the last decade and the financial burden it presents to the NHS.
    Methods: Hospital Episode Statistics for 2010-2019 were used to calculate the number of rectal foreign bodies that required removal in hospital. Data for age groups and genders have been compared.
    Results: A total of 3,500 rectal foreign bodies were removed over the course of 9 years. Males accounted for 85.1% of rectal foreign bodies whilst 14.9% were females. This equates to 348 bed-days per annum. Admission peaks were observed in the second and fifth decades of life.
    Conclusion: This study shows that the incidence of rectal foreign bodies is higher in men and has been increasing over the period studied. Most foreign bodies can be removed trans-anally with the use of anaesthesia, with only a small proportion of patients requiring hospital stay over 24 hours (mean length of stay = 24 hours). Nearly 400 rectal foreign body removals are performed each year with an annual cost of £338,819, illustrating the effect this has on NHS resources.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Foreign Bodies/economics ; Foreign Bodies/epidemiology ; Foreign Bodies/surgery ; Foreign-Body Migration/economics ; Foreign-Body Migration/epidemiology ; Foreign-Body Migration/surgery ; Health Care Costs/statistics & numerical data ; Humans ; Infant ; Length of Stay/economics ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Rectum/surgery ; Sex Factors ; State Medicine/economics ; State Medicine/statistics & numerical data ; United Kingdom/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2020.7129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Corrigendum to "Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy" [J Vet Cardiol 25 (2019 Oct) 41-51].

    Yang, V K / Rush, J E / Bhasin, S / Wagers, A J / Lee, R T

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland Netherlands
    Dokumenttyp Published Erratum
    ZDB-ID 2198278-8
    ISSN 1875-0834 ; 1760-2734
    ISSN (online) 1875-0834
    ISSN 1760-2734
    DOI 10.1016/j.jvc.2024.03.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics.

    Bhasin, Sidharth / Das, Asmita

    Journal of biomolecular structure & dynamics

    2023  , Seite(n) 1–17

    Abstract: SHP1 is a protein tyrosine phosphatase playing a central role in immunity, cell growth, development, and survival. The inhibition of SHP1 can help in better prognosis in various disorders like breast and ovarian cancer, melanoma, atherosclerosis, hypoxia, ...

    Abstract SHP1 is a protein tyrosine phosphatase playing a central role in immunity, cell growth, development, and survival. The inhibition of SHP1 can help in better prognosis in various disorders like breast and ovarian cancer, melanoma, atherosclerosis, hypoxia, hypoactive immune response, and familial dysautonomia. The currently available inhibitors of SHP1 have the side effect of inhibiting the activity of SHP2, which shares >60% sequence similarity with SHP1 but has distinct biological functions. Thus, there is a need to search for novel specific inhibitors of SHP1. The current study uses a combination of virtual screening and molecular dynamic simulations, followed by PCA and MM-GBSA analysis, to screen about 35000 compounds; to predict that two rigidin analogues can potentially selectively inhibit SHP1 but not SHP2. Our studies demonstrate that these rigidin analogues are more potent at inhibiting SHP1 than the commercially available inhibitor NSC-87877. Further, cross-binding studies with SHP2 exhibited poor binding efficiency and lower stability of the complex, thus indicating a specificity of the rigidin analogues for SHP1, which is crucial in preventing side effects due to the diverse physiological functions of SHP2 in cellular signaling, proliferation, and hematopoiesis. Additionally, SHP1 is essential in mediating the inhibitory signaling in antitumor immune cells like NK and T cells. Hence, the rigidin analogues that inhibit SHP1 will potentiate the anti-tumor immune response by the release of inhibitory function of NK cells, thus driving NK activating response, in addition to their intrinsic anti-tumor function. Thus, SHP1 inhibition is a novel double-blade approach towards anti-cancer immunotherapeutics.Communicated by Ramaswamy H. Sarma.
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2227708
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Selective Androgen Receptor Modulators as Function Promoting Therapies.

    Bhasin, S

    The Journal of frailty & aging

    2015  Band 4, Heft 3, Seite(n) 121–122

    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland France
    Dokumenttyp Journal Article
    ISSN 2260-1341
    ISSN 2260-1341
    DOI 10.14283/jfa.2015.65
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Hypogonadism.

    Bhasin, Shalender / Jayasena, Channa N

    Endocrinology and metabolism clinics of North America

    2022  Band 51, Heft 1, Seite(n) xv–xvi

    Mesh-Begriff(e) Humans ; Hypogonadism/diagnosis ; Hypogonadism/therapy ; Testosterone
    Chemische Substanzen Testosterone (3XMK78S47O)
    Sprache Englisch
    Erscheinungsdatum 2022-02-04
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2021.11.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Buch: The therapeutic role of androgens

    Bhasin, Shalender

    (Baillière's clinical endocrinology and metabolism ; 12,3)

    1998  

    Verfasserangabe S. Bhasin, guest ed
    Serientitel Baillière's clinical endocrinology and metabolism ; 12,3
    Überordnung
    Schlagwörter Androgene ; Hormontherapie
    Schlagwörter Hormonsubstitution ; Hormonbehandlung ; Hormonabhängige Therapie ; Hormonbeeinflussbare Therapie ; Hormonersatztherapie ; Hormonersatzbehandlung ; Männliche Sexualhormone
    Sprache Englisch
    Umfang X S., S. 365 - 542
    Verlag Baillière Tindall
    Erscheinungsort London u.a
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT010083809
    ISBN 0-7020-2463-5 ; 978-0-7020-2463-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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