Artikel ; Online: New N-benzhydrylpiperazine/1,3,4-oxadiazoles conjugates inhibit the proliferation, migration, and induce apoptosis in HeLa cancer cells via oxidative stress-mediated mitochondrial pathway.
Journal of cellular biochemistry
2018 Band 120, Heft 2, Seite(n) 1651–1666
Abstract: N-benzhydrylpiperazine and 1,3,4-oxadiazoles are pharmacologically active scaffolds which exhibits significant inhibitory growth effects against various cancer cells, however, antiproliferation effects and the underlying mechanism for inducing apoptosis ... ...
| Abstract | N-benzhydrylpiperazine and 1,3,4-oxadiazoles are pharmacologically active scaffolds which exhibits significant inhibitory growth effects against various cancer cells, however, antiproliferation effects and the underlying mechanism for inducing apoptosis for aforementioned scaffolds addressing HeLa cancer cells remains uncertain. In this study, N-benzhydrylpiperazine clubbed with 1,3,4-oxadiazoles (4a-4h) were synthesized, subsequently characterized using high resolution spectroscopic techniques and eventually evaluated for their antiproliferation potential by inducing apoptosis in HeLa cancer cells. The MTT assay screening results revealed that among all, compound 4d ( N-benzhydryl-4-((5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl)methyl)piperazine) in particular, exhibited IC |
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| Sprache | Englisch | |||||
| Erscheinungsdatum | 2018-09-11 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 392402-6 | |||||
| ISSN | 1097-4644 ; 0730-2312 | |||||
| ISSN (online) | 1097-4644 | |||||
| ISSN | 0730-2312 | |||||
| DOI | 10.1002/jcb.27472 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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