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  1. Artikel ; Online: Preoperative

    Bhudia, Nisha / Bakhai, Ameet / Baumber, Rachel

    Annals of internal medicine

    2020  Band 172, Heft 12, Seite(n) 842–843

    Mesh-Begriff(e) Cardiovascular Diseases/etiology ; Cohort Studies ; Humans ; Natriuretic Peptide, Brain ; Peptide Fragments ; Predictive Value of Tests
    Chemische Substanzen Peptide Fragments ; Natriuretic Peptide, Brain (114471-18-0)
    Sprache Englisch
    Erscheinungsdatum 2020-06-12
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-0268
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.178/2: Hefte anzeigen Standort:
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  2. Artikel ; Online: Critical care pharmacy service provision and workforce in adult extracorporeal membrane oxygenation centres: a multicentre cross-sectional survey.

    Remmington, Christopher / Cameron, Lynda / Hanks, Fraser / Liang, Ya-Hui / Barrow, Linda / Coxhead, Ruth / Mehta, Reena / Bhudia, Nisha / Lyster, Haifa / Cooke, Sarah / Gilmartin, James / Lee, Phillisa / Sloss, Rhona / McKenzie, Cathrine

    International journal of clinical pharmacy

    2024  

    Abstract: Background: There is good evidence describing pharmacy workforce and service provision in general critical care units. However, no data exist from adult extracorporeal membrane oxygenation (ECMO) centres.: Aim: To describe workforce characteristics, ... ...

    Abstract Background: There is good evidence describing pharmacy workforce and service provision in general critical care units. However, no data exist from adult extracorporeal membrane oxygenation (ECMO) centres.
    Aim: To describe workforce characteristics, pharmacy service provision, and pharmaceutical care activities in critical care units (CCUs) providing an adult ECMO service in the United Kingdom (UK) and compare to national staffing standards for CCUs.
    Method: We conducted a multicentre, cross-sectional electronic survey inviting one pharmacy professional response per UK ECMO centre. We collated information on workforce, service provision, and pharmaceutical care activities provided by pharmacy teams in adult CCUs with an ECMO service.
    Results: The survey response rate was 90.9%: representatives of 10/11 tertiary hospitals providing ECMO services responded. Median critical care pharmacist to critical care bed was 1:12.1 (IQR: 1:9.4-1:14.9). Most centres (90.0%) did not meet national standards for pharmacy professionals to critical care bed staffing ratios for weekday services. Total critical care beds covered by the critical care pharmacy team varied across the UK: median (IQR) - 45 (37-80) beds. Two centres funded pharmacist time for ECMO activity, and one centre funded a pharmacy technician post. Median peak ECMO activity was 4 ECMO patients in a single day (IQR: 3-5). Most respondents reported reduced pharmacy service at weekends compared to weekday, with limited on-site support.
    Conclusion: Most responding ECMO centres in the UK reported pharmacy staffing ratios below nationally agreed critical care standards. There was high variability in clinical pharmacy services to ECMO patients over 7 days.
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2601204-2
    ISSN 2210-7711 ; 2210-7703 ; 0928-1231
    ISSN (online) 2210-7711
    ISSN 2210-7703 ; 0928-1231
    DOI 10.1007/s11096-024-01719-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Author Correction: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.

    Bhudia, Nisha / Desai, Sapna / King, Natalie / Ancellin, Nicolas / Grillot, Didier / Barnes, Ashley A / Dowell, Simon J

    Scientific reports

    2020  Band 10, Heft 1, Seite(n) 5097

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Sprache Englisch
    Erscheinungsdatum 2020-03-17
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-62011-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.

    Bhudia, Nisha / Desai, Sapna / King, Natalie / Ancellin, Nicolas / Grillot, Didier / Barnes, Ashley A / Dowell, Simon J

    Scientific reports

    2020  Band 10, Heft 1, Seite(n) 1004

    Abstract: The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but attributing biological significance to their G protein signalling function still ... ...

    Abstract The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but attributing biological significance to their G protein signalling function still presents a major challenge. Here, utilising activated truncated forms of the receptors, we show that ADGRE2/EMR2 and ADGRE5/CD97 are G protein-coupled in a variety of recombinant systems. In a yeast-based assay, where heterologous GPCRs are coupled to chimeric G proteins, EMR2 showed broad G protein-coupling, whereas CD97 coupled more specifically to G
    Mesh-Begriff(e) Antibodies/immunology ; Antigens, CD/metabolism ; Blotting, Western ; GTP-Binding Proteins/metabolism ; HEK293 Cells/metabolism ; Humans ; Immunoprecipitation ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/drug effects
    Chemische Substanzen ADGRE2 protein, human ; ADGRE5 protein, human ; Antibodies ; Antigens, CD ; Receptors, G-Protein-Coupled ; GTP-Binding Proteins (EC 3.6.1.-)
    Sprache Englisch
    Erscheinungsdatum 2020-01-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-57989-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Anaesthetic medicines: back to basics.

    Cox, Felicia / Bhudia, Nisha

    Journal of perioperative practice

    2009  Band 19, Heft 11, Seite(n) 387–394

    Abstract: Anaesthesia has developed since the first description of curare. Today there are a myriad of anaesthetic and analgesic medicines available. This article explores the function of medicines in a patient's perioperative journey and describes how ... ...

    Abstract Anaesthesia has developed since the first description of curare. Today there are a myriad of anaesthetic and analgesic medicines available. This article explores the function of medicines in a patient's perioperative journey and describes how pharmacokinetics and pharmacodynamics play such a large role. The different routes of administration are described and the main categories of anaesthetic medicines outlined. The characteristics and precautions associated with the different classes of medicines are highlighted.
    Mesh-Begriff(e) Anesthetics/administration & dosage ; Drug Administration Routes ; Humans
    Chemische Substanzen Anesthetics
    Sprache Englisch
    Erscheinungsdatum 2009-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2226186-2
    ISSN 1750-4589
    ISSN 1750-4589
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4006: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 83: Hefte anzeigen

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  6. Artikel: Pharmacological properties of acid N-thiazolylamide FFA2 agonists.

    Brown, Andrew J / Tsoulou, Christina / Ward, Emma / Gower, Elaine / Bhudia, Nisha / Chowdhury, Forhad / Dean, Tony W / Faucher, Nicolas / Gangar, Akanksha / Dowell, Simon J

    Pharmacology research & perspectives

    2015  Band 3, Heft 3, Seite(n) e00141

    Abstract: FFA2 is a receptor for short-chain fatty acids. Propionate (C3) and 4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide (4-CMTB), the prototypical synthetic FFA2 agonist, evoke calcium mobilization in neutrophils and inhibit lipolysis in adipocytes ...

    Abstract FFA2 is a receptor for short-chain fatty acids. Propionate (C3) and 4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide (4-CMTB), the prototypical synthetic FFA2 agonist, evoke calcium mobilization in neutrophils and inhibit lipolysis in adipocytes via this G-protein-coupled receptor. 4-CMTB contains an N-thiazolylamide motif but no acid group, and 4-CMTB and C3 bind to different sites on FFA2 and show allosteric cooperativity. Recently, FFA2 agonists have been described that contain both N-thiazolylamide and carboxylate groups, reminiscent of bitopic ligands. These are thought to engage the carboxylate-binding site on FFA2, but preliminary evidence suggests they do not bind to the same site as 4-CMTB even though both contain N-thiazolylamide. Here, we describe the characterization of four FFA2 ligands containing both N-thiazolylamide and carboxylate. (R)-3-benzyl-4-((4-(2-chlorophenyl)thiazol-2-yl)(methyl)amino)-4-oxobutanoic acid (compound 14) exhibits allosteric agonism with 4-CMTB but not C3. Three other compounds agonize FFA2 in [(35)S]GTPγS-incorporation or cAMP assays but behave as inverse agonists in yeast-based gene-reporter assays, showing orthosteric antagonism of C3 responses but allosteric antagonism of 4-CMTB responses. Thus, the bitopic-like FFA2 ligands engage the orthosteric site but do not compete at the site of 4-CMTB binding on an FFA2 receptor molecule. Compound 14 activates FFA2 on human neutrophils and mouse adipocytes, but appears not to inhibit lipolysis upon treatment of human primary adipocytes in spite of the presence of a functional FFA2 receptor in these cells. Hence, these new ligands may reveal differences in coupling of FFA2 between human and rodent adipose tissues.
    Sprache Englisch
    Erscheinungsdatum 2015-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2740389-0
    ISSN 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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