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  1. Artikel: The Role of Potassium and Calcium Currents in the Bistable Firing Transition.

    Borges, Fernando S / Protachevicz, Paulo R / Souza, Diogo L M / Bittencourt, Conrado F / Gabrick, Enrique C / Bentivoglio, Lucas E / Szezech, José D / Batista, Antonio M / Caldas, Iberê L / Dura-Bernal, Salvador / Pena, Rodrigo F O

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Healthy brains display a wide range of firing patterns, from synchronized oscillations during slowwave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic ... ...

    Abstract Healthy brains display a wide range of firing patterns, from synchronized oscillations during slowwave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking cells (RS) with frequency adaptation and do not exhibit bursts in current-clamp experiments (
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.08.16.553625
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.

    Borges, Fernando S / Protachevicz, Paulo R / Souza, Diogo L M / Bittencourt, Conrado F / Gabrick, Enrique C / Bentivoglio, Lucas E / Szezech, José D / Batista, Antonio M / Caldas, Iberê L / Dura-Bernal, Salvador / Pena, Rodrigo F O

    Brain sciences

    2023  Band 13, Heft 9

    Abstract: Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic ... ...

    Abstract Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking (RS) cells with frequency adaptation and do not exhibit bursts in current-clamp experiments (in vitro). In this work, we investigate the transition mechanism of spike-to-burst patterns due to slow potassium and calcium currents, considering a conductance-based model of a cortical RS cell. The joint influence of potassium and calcium ion channels on high synchronous patterns is investigated for different synaptic couplings (gsyn) and external current inputs (
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13091347
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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