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  1. Artikel: [Expression and influencing factors of hepcidin in classical paroxysmal nocturnal hemoglobinuria].

    Wang, Y S / Yao, H J / Bo, L J / Zhao, Y P / Zhang, Y L / Zhang, F K

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

    2019  Band 40, Heft 10, Seite(n) 818–821

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Enzyme-Linked Immunosorbent Assay ; Ferritins ; Hemoglobinuria, Paroxysmal ; Hepcidins ; Humans ; Retrospective Studies
    Chemische Substanzen Hepcidins ; Ferritins (9007-73-2)
    Sprache Chinesisch
    Erscheinungsdatum 2019-11-24
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 0253-2727
    ISSN 0253-2727
    DOI 10.3760/cma.j.issn.0253-2727.2019.10.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Bioinformatics analysis of miRNA expression profile between primary and recurrent glioblastoma.

    Bo, L-J / Wei, B / Li, Z-H / Wang, Z-F / Gao, Z / Miao, Z

    European review for medical and pharmacological sciences

    2015  Band 19, Heft 19, Seite(n) 3579–3586

    Abstract: Objective: Glioblastoma (GBM) is the most malignant brain tumor with rapid relapse. The goal of this study is to identify microRNAs (miRNAs) involved in recurrent GBM.: Materials and methods: miRNA transcription profile data (GSE32466) were ... ...

    Abstract Objective: Glioblastoma (GBM) is the most malignant brain tumor with rapid relapse. The goal of this study is to identify microRNAs (miRNAs) involved in recurrent GBM.
    Materials and methods: miRNA transcription profile data (GSE32466) were downloaded, including 12 primary GBM samples and 12 recurrent GBM samples. Then, limma package was utilized to identify differentially expressed miRNAs (DEMs) with the criteria of false discovery rate < 0.05 and |log2 fold change| ≥ 1. Thereafter, miTarget and TargetScan databases were used to predict the potential target genes of DEMs. Regulatory co-expression network was constructed based on co-expressed genes and potential miRNA-gene pairs, and then, pathway analysis was conducted. Furthermore, database miRWalk was used to screen out known GBM-associated miRNAs from the identified DEMs.
    Results: A total of 71 DEMs were identified between primary and recurrent GBM samples, and 2684 potential target genes were found. Besides, regulatory co-expression network was constructed, including 12 DEMs and 81 potential target genes. These genes significantly enriched in ECM-receptor interaction, ribosome, and focal adhesion pathways, and DEMs like hsa-miR-320a, hsa-miR-139-5p, has-miR-128, hsa-miR-140-5p, and hsa-miR-146b-5p had high degree. Notably, 7 DEMs in network were known GBM-associated miRNAs recorded in database miRWalk.
    Conclusions: DEMs like hsa-miR-320a, hsa-miR-139-5p, has-miR-128, hsa-miR-146b-5p, hsa-let-7c, hsa-miR-128, and hsa-let-7a might participate in recurrent GBM. These results would pave ways for further study of recurrent GBM mechanism, and for the prevention and treatment of recurrent GBM. However, more experimental verifications are required to prove these predictions.
    Mesh-Begriff(e) Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Computational Biology/methods ; Databases, Factual ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; MicroRNAs/metabolism ; Neoplasm Recurrence, Local
    Chemische Substanzen MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2015-10
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Survey of seven organophosphorus pesticides in drinking water, feedstuffs and raw milk from dairy farms in the Province Heilongjiang during 2008-2009

    Zhao, X. H. / Bo, L.-J. / Wang, J. Jing / Li, T. J.

    Milchwissenschaft

    2012  Band 67, Heft 3, Seite(n) 293–296

    Sprache Deutsch ; Englisch
    Dokumenttyp Artikel
    ZDB-ID 391678-9
    ISSN 0026-3788
    Datenquelle Current Contents Ernährung, Umwelt, Agrar

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