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  1. Artikel ; Online: A HPLC-MS/MS method for the determination of Nadolol in rat plasma: Development, validation, and application to pharmacokinetic study.

    Kanjarla, Narasimha / Pasupuleti, Bhuvanachandra / Boggula, Narender / Kusuma, Praveen K / Kothapally, Daniel / Gone, Vamshikrishna / Kiran, Gangarapu

    European journal of mass spectrometry (Chichester, England)

    2023  Band 29, Heft 3, Seite(n) 170–180

    Abstract: A sensitive validated method has been developed for the quantification of Nadolol in rat plasma by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) using deuterated Nadolol (Nadolol D9) as internal standard (IS). ... ...

    Abstract A sensitive validated method has been developed for the quantification of Nadolol in rat plasma by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) using deuterated Nadolol (Nadolol D9) as internal standard (IS). The liquid-liquid extraction method using ethyl acetate was employed for the sample pretreatment. The separation was achieved on the Agilent Zorbax XDB C18 column (150  mm  ×  4.6  mm ID., 3.5  μm). The column temperature was controlled at 30°C. The components were eluted by using mobile phase A (10  mM ammonium formate) and mobile phase B (acetonitrile) in the ratio of 20:80  v/v with a flow rate of 0.5  mL/min. And 15  μL aliquot was injected in an isocratic elution mode with a total run time of 2.5  min. The multiple reactions monitoring transitions, m/z 310.20/254.10 for Nadolol and IS 319.20/255.00 were selected to achieve high selective analysis. The method exhibited great selectivity and linearity over the concentration range of 6 to 3000  ng/mL. The lower limit of quantification was found to be 6  ng/mL. The developed method proved acceptable results on selectivity, sensitivity, precision, accuracy, and stability studies as per Food and Drug Administration guidelines. This HPLC-MS/MS assay was successfully applied to get the pharmacokinetics parameters in rat plasma.
    Mesh-Begriff(e) Rats ; Animals ; Chromatography, High Pressure Liquid/methods ; Nadolol ; Tandem Mass Spectrometry/methods ; Plasma ; Liquid-Liquid Extraction/methods ; Reproducibility of Results
    Chemische Substanzen Nadolol (42200-33-9)
    Sprache Englisch
    Erscheinungsdatum 2023-06-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1751-6838
    ISSN (online) 1751-6838
    DOI 10.1177/14690667231179569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Novel Coronavirus Disease (Covid-19)

    Sripriya, Ieppala / Reddy, A. Vishal / Shalini, Nellutla / Boggula, Narender

    Research and Advances in Pharmacy and Life Sciences; Vol 2, No; 17-28

    A Literature Based Review

    2020  Band 2

    Abstract: Currently, the emergence of a novel human coronavirus (SARS-CoV-2) has become a global health concern causing severe respiratory tract infections in humans as well as in animal too. The 2019-novel coronavirus (nCoV) is a major source of disaster in the ... ...

    Abstract Currently, the emergence of a novel human coronavirus (SARS-CoV-2) has become a global health concern causing severe respiratory tract infections in humans as well as in animal too. The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21st century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. Currently, the emergence of a novel human coronavirus (SARS-CoV-2) has become a global health concern causing severe respiratory tract infections in humans. A human-to-human transmission has been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronavirus on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. Currently, the research on novel coronavirus is still in the primary stage till now. Based on the current published evidence, we systematically summarize the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. In December 2019, several patients from Wuhan, China were admitted to hospitals with symptoms of pneumonia. As the number of patients presenting with similar symptoms started to rise, the causative agent was eventually isolated from samples. It was initially called the 2019 novel coronavirus (2019-nCoV) and has been recently relabelled as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the disease it causes has been named coronavirus disease 2019 (COVID-19). Over the next few weeks, the virus spread from Wuhan to affect different provinces in China and, after a few months, it is now present in 109 countries. This review in the hope of helping the public effectively recognize and deal with the 2019 novel coronavirus (SARS-CoV-2). The global impact of this new epidemic is yet uncertain.
    Schlagwörter covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-05-13
    Verlag Research and Advances in Pharmacy and Life Sciences
    Erscheinungsland in
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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