Artikel ; Online: Experimental Mouse Models of Asthma and Analysis of CD4 T Cells.
Methods in molecular biology (Clifton, N.J.)
2021 Band 2285, Seite(n) 329–348
Abstract: Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are key ... ...
Abstract | Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are key players in a large proportion of cases, while other CD4+ T cell subsets are also implicated in driving and limiting pathology. In this chapter, we describe methods for establishing allergic airway disease to model asthma in adult and neonatal mice, along with protocols for measuring key disease parameters and quantifying and phenotyping CD4+ T cell subtypes. |
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Mesh-Begriff(e) | Age Factors ; Animals ; Asthma/immunology ; Asthma/metabolism ; Asthma/pathology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Separation ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Flow Cytometry ; Immunohistochemistry ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Phenotype ; Research Design ; Workflow ; Mice |
Chemische Substanzen | Cytokines |
Sprache | Englisch |
Erscheinungsdatum | 2021-04-09 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ISSN | 1940-6029 |
ISSN (online) | 1940-6029 |
DOI | 10.1007/978-1-0716-1311-5_25 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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