Artikel ; Online: Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry.
2023 Band 46, Heft 12, Seite(n) 2162–2170
Abstract: Objective: Type 2 diabetes (T2D) is a major driver of chronic diseases around the globe. The aim was to assess the impact of T2D on the outcomes of solid organ transplantations.: Research design and methods: We used the Scientific Registry of ... ...
| Abstract | Objective: Type 2 diabetes (T2D) is a major driver of chronic diseases around the globe. The aim was to assess the impact of T2D on the outcomes of solid organ transplantations. Research design and methods: We used the Scientific Registry of Transplant Recipients from 2006 to 2021 to collect data for all patients age ≥18 years who received a lung, heart, liver, or kidney transplant in the U.S. Results: We included 462,692 solid organ transplant recipients: 31,503 lung, 38,004 heart, 106,639 liver, and 286,440 kidney transplantations. The prevalence of pretransplantation T2D was 15% in lung, 26% in heart, 25% in liver, and 30% in kidney transplant recipients, increasing over time. Posttransplantation mortality was significantly higher among transplant recipients with T2D versus those without T2D (lung 32.1% vs. 29.3% [3 years], 46.4% vs. 42.6% [5 years]; P < 0.01; heart 11.2% vs. 9.1% [1 year], 24.4% vs. 20.6% [5 years]; P < 0.0001; liver 10.6% vs. 8.9% [1 year], 26.2% vs. 22.0% [5 years]; P < 0.0001; kidney 5.3% vs. 2.5% [1 year], 20.8% vs. 10.1% [5 years]; P < 0.0001). Independent association of pretransplantation T2D with higher posttransplantation mortality was significant after adjustment for clinicodemographic confounders (adjusted hazard ratio in lung transplant recipients 1.08 [95% CI 1.03-1.13]; heart 1.26 [1.20-1.32]; liver 1.25 [1.21-1.28]; kidney 1.65 [1.62-1.68]; P < 0.01). Conclusions: The prevalence of T2D in solid organ transplantation candidates is increasing. In all solid organ transplantations, pretransplantation T2D was independently associated with higher posttransplantation mortality, most profoundly in kidney transplantations. |
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| Mesh-Begriff(e) | Humans ; Adolescent ; Diabetes Mellitus, Type 2/epidemiology ; Incidence ; Organ Transplantation/adverse effects ; Kidney Transplantation ; Registries ; Retrospective Studies | ||||||||||
| Sprache | Englisch | ||||||||||
| Erscheinungsdatum | 2023-09-25 | ||||||||||
| Erscheinungsland | United States | ||||||||||
| Dokumenttyp | Journal Article | ||||||||||
| ZDB-ID | 441231-x | ||||||||||
| ISSN | 1935-5548 ; 0149-5992 | ||||||||||
| ISSN (online) | 1935-5548 | ||||||||||
| ISSN | 0149-5992 | ||||||||||
| DOI | 10.2337/dc23-1085 | ||||||||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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