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  1. Artikel: JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation

    Braun-Dullaeus, Rüdiger / Mohr, Juliane / Amthauer, Holger / Heidel, Florian / Müller, Andreas

    The journal of clinical investigation, 128(10):4359-4371

    2018  

    Abstract: JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and leukocytes. However, the mechanism by which the 2 major leukocyte integrin chains, ... ...

    Körperschaft Leibniz-Institut für Alternsforschung
    Leibniz-Institut für Neurobiologie
    Abstract JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and leukocytes. However, the mechanism by which the 2 major leukocyte integrin chains, β1 and β2, may contribute to CMN pathophysiology remained unclear. β1 (α4β1; VLA-4) and β2 (αLβ2; LFA-1) integrins are essential regulators for attachment of leukocytes to endothelial cells. We here showed enhanced adhesion of granulocytes from mice with JAK2-V617F knockin (JAK2+/VF mice) to vascular cell adhesion molecule 1– (VCAM1-) and intercellular adhesion molecule 1–coated (ICAM1-coated) surfaces. Soluble VCAM1 and ICAM1 ligand binding assays revealed increased affinity of β1 and β2 integrins for their respective ligands. For β1 integrins, this correlated with a structural change from the low- to the high-affinity conformation induced by JAK2-V617F. JAK2-V617F triggered constitutive activation of the integrin inside-out signaling molecule Rap1, resulting in translocation toward the cell membrane. Employing a venous thrombosis model, we demonstrated that neutralizing anti–VLA-4 and anti–β2 integrin antibodies suppress pathologic thrombosis as observed in JAK2+/VF mice. In addition, aberrant homing of JAK2+/VF leukocytes to the spleen was inhibited by neutralizing anti-β2 antibodies and by pharmacologic inhibition of Rap1. Thus, our findings identified cross-talk between JAK2-V617F and integrin activation promoting pathologic thrombosis and abnormal trafficking of leukocytes to the spleen.
    Schlagwörter Hematology ; Integrins ; Thrombosis
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle Fachrepositorium Lebenswissenschaften

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  2. Artikel ; Online: Confusion in connection with pulmonary hypertension due to premature ventricular complexes requires diagnostic work-up.

    Luani, Blerim / Wiemer, Marcus / Braun-Dullaeus, Rüdiger C

    European heart journal. Case reports

    2023  Band 7, Heft 7, Seite(n) ytad321

    Sprache Englisch
    Erscheinungsdatum 2023-07-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad321
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Dissertation / Habilitation: Der Zellzyklus in der vaskulären Medizin

    Braun-Dullaeus, Rüdiger

    2002  

    Verfasserangabe vorgelegt von Rüdiger Christian Braun-Dullaeus
    Sprache Deutsch ; Englisch
    Umfang 62, [162] Bl. : Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Gießen, Univ., Habil.-Schr., 2002
    HBZ-ID HT015026007
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Artikel ; Online: Confusion in a patient with premature ventricular complexes originating in the left ventricular summit.

    Luani, Blerim / Schmeisser, Alexander / Wiemer, Marcus / Braun-Dullaeus, Rüdiger C

    European heart journal. Case reports

    2023  Band 7, Heft 4, Seite(n) ytad142

    Abstract: Background: Premature ventricular complexes (PVCs) originating in the ventricular outflow tracts are mostly of benign character.: Case summary: We describe a rare case of pulmonary hypertension with severe hypoxaemia and confusion caused by a ... ...

    Abstract Background: Premature ventricular complexes (PVCs) originating in the ventricular outflow tracts are mostly of benign character.
    Case summary: We describe a rare case of pulmonary hypertension with severe hypoxaemia and confusion caused by a significant mitral regurgitation (MR) during PVC originating in the left ventricle summit. After successful PVC ablation, all above-mentioned clinical parameters had normalized.
    Discussion: Premature ventricular complexes originating in the outflow tracts should be considered as a potential though rare cause of severe MR and pulmonary hypertension.
    Sprache Englisch
    Erscheinungsdatum 2023-03-28
    Erscheinungsland England
    Dokumenttyp Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad142
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: In Reply.

    Genz, Conrad / Braun-Dullaeus, Ruediger C

    Deutsches Arzteblatt international

    2022  Band 118, Heft 43, Seite(n) 739–740

    Sprache Englisch
    Erscheinungsdatum 2022-01-27
    Erscheinungsland Germany
    Dokumenttyp Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0302
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  6. Artikel ; Online: Medical education during the Covid-19 pandemic long-term experiences of German clinical medical students.

    Gottschalk, Marc / Milch, Pascal M / Albert, Christian / Werwick, Katrin / Braun-Dullaeus, Ruediger C / Stieger, Philipp

    PloS one

    2023  Band 18, Heft 6, Seite(n) e0286642

    Abstract: Introduction: Due to the Covid-19 pandemic and the accompanying hygiene regulations, medical students in Germany faced multiple educational and personal challenges. The challenges included the cancellation and digitalisation of courses, the closing of ... ...

    Abstract Introduction: Due to the Covid-19 pandemic and the accompanying hygiene regulations, medical students in Germany faced multiple educational and personal challenges. The challenges included the cancellation and digitalisation of courses, the closing of university institutions such as libraries, a decrease in social contacts, and the risk of a Covid-19 infection. The aim of this study was to understand medical students' pandemic experiences as well as the consequences of these experiences for the students' future work as physicians.
    Materials and methods: We performed 15 guided, one-on-one interviews with clinical medical students (third to fifth year) at the Otto-von-Guericke-University Magdeburg. Interviews were recorded, transcribed, and anonymised. We performed a qualitative content analysis in accordance with Mayring and thereby formed an inductive category system. The Consolidated Criteria for Reporting Qualitative Research (COREQ) were applied.
    Results: Five categories were inductively formed: "Changes in the teaching experience", "negative effects on the learning experience", "decrease in personal social contacts", "contact with covid-19", and "pandemic-associated stress increase". The participating students reported higher levels of stress due to isolation and uncertainty regarding their educational future. Furthermore, students welcomed the digitalisation of lectures, developed individual coping strategies, and voluntarily took part in the care of Covid-19 patients. Limitations to social interactions were perceived as the major restrictive factor to their educational structure, their perceived learning success and personal development.
    Conclusion: This study identified social restrictions as well as didactic and academic structural challenges as relevant factors contributing to perceived stress and fear for medical students during the Covid-19 pandemic, especially as regards their learning experience. Students' acceptance of digitalised learning may enable regular interaction with university peers and may facilitate a structured educational life. However, the implementation of digital resources could not provide a sufficient substitute for in-person courses.
    Mesh-Begriff(e) Humans ; Students, Medical ; Pandemics ; COVID-19/epidemiology ; Educational Status ; Education, Medical
    Sprache Englisch
    Erscheinungsdatum 2023-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286642
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Cerebral embolic protection during transcatheter aortic valve replacement: a systematic review and meta-analysis of propensity score matched and randomized controlled trials using the Sentinel cerebral embolic protection device.

    Wolfrum, Mathias / Handerer, Immanuel Justus / Moccetti, Federico / Schmeisser, Alexander / Braun-Dullaeus, Ruediger C / Toggweiler, Stefan

    BMC cardiovascular disorders

    2023  Band 23, Heft 1, Seite(n) 306

    Abstract: Background: The Sentinel cerebral embolic protection device (CEP) aims to reduce the risk of stroke during transcatheter aortic valve replacement (TAVR). We performed a systematic review and meta-analysis of propensity score matched (PSM) and randomized ...

    Abstract Background: The Sentinel cerebral embolic protection device (CEP) aims to reduce the risk of stroke during transcatheter aortic valve replacement (TAVR). We performed a systematic review and meta-analysis of propensity score matched (PSM) and randomized controlled trials (RCT) investigating the effect of the Sentinel CEP to prevent strokes during TAVR.
    Methods: Eligible trials were searched through PubMed, ISI Web of science databases, Cochrane database, and proceedings of major congresses. Primary outcome was stroke. Secondary outcomes included all-cause mortality, major or life-threatening bleeding, major vascular complications and acute kidney injury at discharge. Fixed and random effect models were used to calculate the pooled risk ratio (RR) with 95% confidence intervals (CI) and absolute risk difference (ARD).
    Results: A total of 4066 patients from 4 RCTs (3'506 patients) and 1 PSM study (560 patients) were included. Use of Sentinel CEP was successful in 92% of patients and was associated with a significantly lower risk of stroke (RR: 0.67, 95% CI: 0.48-0.95, p = 0.02. ARD: -1.3%, 95% CI: -2.3 - -0.2, p = 0.02, number needed to treat (NNT) = 77), and a reduced risk of disabling stroke (RR: 0.33, 95% CI: 0.17-0.65. ARD: -0.9%, 95% CI: -1.5 - -0.3, p = 0.004, NNT = 111). Use of Sentinel CEP was associated with a lower risk of major or life-threatening bleeding (RR: 0.37, 95% CI: 0.16-0.87, p = 0.02). Risk for nondisabling stroke (RR: 0.93, 95% CI: 0.62-1.40, p = 0.73), all-cause mortality (RR: 0.70, 95% CI: 0.35-1.40, p = 0.31), major vascular complications (RR: 0.74, 95% CI: 0.33-1.67, p = 0.47) and acute kidney injury (RR: 0.74, 95% CI: 0.37-1.50, p = 0.40) were similar.
    Conclusions: The use of CEP during TAVR was associated with lower risks of any stroke and disabling stroke with an NNT of 77 and 111, respectively.
    Mesh-Begriff(e) Humans ; Transcatheter Aortic Valve Replacement ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications ; Propensity Score ; Risk Factors ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Stroke/etiology ; Stroke/prevention & control ; Embolic Protection Devices ; Intracranial Embolism/diagnostic imaging ; Intracranial Embolism/etiology ; Intracranial Embolism/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2023-06-17
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03338-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CardioGenesis4D: Interactive Morphological Transitions of Embryonic Heart Development in a Virtual Learning Environment.

    Schott, Danny / Kunz, Matthias / Wunderling, Tom / Heinrich, Florian / Braun-Dullaeus, Rudiger / Hansen, Christian

    IEEE transactions on visualization and computer graphics

    2023  Band PP

    Abstract: In the embryonic human heart, complex dynamic shape changes take place in a short period of time on a microscopic scale, making this development difficult to visualize. However, spatial understanding of these processes is essential for students and ... ...

    Abstract In the embryonic human heart, complex dynamic shape changes take place in a short period of time on a microscopic scale, making this development difficult to visualize. However, spatial understanding of these processes is essential for students and future cardiologists to properly diagnose and treat congenital heart defects. Following a user centered approach, the most crucial embryological stages were identified and translated into a virtual reality learning environment (VRLE) to enable the understanding of the morphological transitions of these stages through advanced interactions. To address individual learning types, we implemented different features and evaluated the application regarding usability, perceived task load, and sense of presence in a user study. We also assessed spatial awareness and knowledge gain, and finally obtained feedback from domain experts. Overall, students and professionals rated the application positively. To minimize distraction from interactive learning content, such VRLEs should consider features for different learning types, allow for gradual habituation, and at the same time provide enough playful stimuli. Our work previews how VR can be integrated into a cardiac embryology education curriculum.
    Sprache Englisch
    Erscheinungsdatum 2023-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2023.3247110
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  9. Artikel ; Online: Was der (Allgemein- und Viszeral‑)Chirurg über die Thromboseprophylaxe wissen sollte.

    Meißler, Saskia / Braun-Dullaeus, Rüdiger / Hansen, Michael / Meyer, Frank

    Chirurgie (Heidelberg, Germany)

    2022  Band 93, Heft 7, Seite(n) 676–686

    Abstract: A persisting problem in the clinical operative routine is surgery-associated venous thromboembolisms with the possible complications. The competent and reliably realized prophylaxis of thromboembolism is part of the original and elementary tasks of the ... ...

    Titelübersetzung What the (general and abdominal) surgeon should know about thrombosis prophylaxis.
    Abstract A persisting problem in the clinical operative routine is surgery-associated venous thromboembolisms with the possible complications. The competent and reliably realized prophylaxis of thromboembolism is part of the original and elementary tasks of the surgeon, both the operator as well as the clinically active physician. Many preventive approaches were developed and established in the daily management but a residual risk for development of thrombosis still remains. Under this aspect a search was carried out particularly with respect to scientific literature with review and guideline character on the topic of risk stratification, prophylactic procedures in general and for specific indications.
    Mesh-Begriff(e) Anticoagulants/adverse effects ; Humans ; Surgeons ; Thromboembolism/drug therapy ; Thrombosis/etiology ; Venous Thrombosis/prevention & control
    Chemische Substanzen Anticoagulants
    Sprache Deutsch
    Erscheinungsdatum 2022-02-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-021-01568-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Baxter Physioneal, Extraneal, Nutrineal (PEN) and Dianeal solution bags can be accidentally connected to Fresenius peritoneal dialysis catheter extensions in a non-sterile manner.

    Albert, Annemarie / Richter, Stefan / Woitas, Rainer Peter / Hinkel, Ulrich Paul / Stieger, Philipp / Braun-Dullaeus, Rüdiger C / Albert, Christian

    Clinical kidney journal

    2024  Band 17, Heft 4, Seite(n) sfae067

    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae067
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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