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  1. Artikel ; Online: "When I'm Thinking Straight, I Can Put Things in Place for When I'm Not." | Exploring the Use of Advance Statements in First-Episode Psychosis Treatment: Young People, Clinician, and Carer Perspectives.

    Valentine, Lee / Grace, Dawson / Pryor, Ingrid / Buccilli, Kate / Sellars, Marcus / Francey, Shona / Simmons, Magenta

    Community mental health journal

    2020  Band 57, Heft 1, Seite(n) 18–28

    Abstract: Advance statements represent a promising but relatively unexplored means to empower young people with first-episode psychosis to actively participate in their own mental health care. This qualitative study explored the use of advance statement's for ... ...

    Abstract Advance statements represent a promising but relatively unexplored means to empower young people with first-episode psychosis to actively participate in their own mental health care. This qualitative study explored the use of advance statement's for young people with first-episode psychosis, as well as their carers and clinicians, and provided actionable feedback on how to better meet the needs and preferences of these key stakeholders and more effectively implement advance statements in clinical settings.
    Sprache Englisch
    Erscheinungsdatum 2020-10-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215855-3
    ISSN 1573-2789 ; 0010-3853
    ISSN (online) 1573-2789
    ISSN 0010-3853
    DOI 10.1007/s10597-020-00721-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Correction to: "When I'm Thinking Straight, I Can Put Things in Place for When I'm Not." | Exploring the Use of Advance Statements in First-Episode Psychosis Treatment: Young People, Clinician, and Carer Perspectives.

    Valentine, Lee / Grace, Dawson / Pryor, Ingrid / Buccilli, Kate / Sellars, Marcus / Francey, Shona / Simmons, Magenta

    Community mental health journal

    2020  Band 57, Heft 1, Seite(n) 29

    Sprache Englisch
    Erscheinungsdatum 2020-10-30
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 215855-3
    ISSN 1573-2789 ; 0010-3853
    ISSN (online) 1573-2789
    ISSN 0010-3853
    DOI 10.1007/s10597-020-00736-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Erythrocyte membrane fatty acid concentrations and myelin integrity in young people at ultra-high risk of psychosis.

    Collins, Melissa / Bartholomeusz, Cali / Mei, Cristina / Kerr, Melissa / Spark, Jessica / Wallis, Nicky / Polari, Andrea / Baird, Shelley / Buccilli, Kate / Dempsey, Sarah-Jane A / Ferguson, Natalie / Formica, Melanie / Krcmar, Marija / Quinn, Amelia L / Wannan, Cassandra / Oldham, Stuart / Fornito, Alex / Mebrahtu, Yohannes / Ruslins, Arlan /
    Street, Rebekah / Loschiavo, Keana / McGorry, Patrick D / Nelson, Barnaby / Amminger, G Paul

    Psychiatry research

    2024  Band 337, Seite(n) 115966

    Abstract: Decreased white matter (WM) integrity and disturbance in fatty acid composition have been reported in individuals at ultra-high risk of psychosis (UHR). The current study is the first to investigate both WM integrity and erythrocyte membrane ... ...

    Abstract Decreased white matter (WM) integrity and disturbance in fatty acid composition have been reported in individuals at ultra-high risk of psychosis (UHR). The current study is the first to investigate both WM integrity and erythrocyte membrane polyunsaturated fatty acid (PUFA) levels as potential risk biomarkers for persistent UHR status, and global functioning in UHR individuals. Forty UHR individuals were analysed at baseline for erythrocyte membrane PUFA concentrates. Tract-based spatial statistics (TBSS) was used to analyse fractional anisotropy (FA) and diffusivity measures. Measures of global functioning and psychiatric symptoms were evaluated at baseline and at 12-months. Fatty acids and WM indices did not predict functional outcomes at baseline or 12-months. Significant differences were found in FA between UHR remitters and non-remitters (individuals who no longer met UHR criteria versus those who continued to meet criteria at 12-months). Docosahexaenoic acid (DHA) was found to be a significant predictor of UHR status at 12-months, as was the interaction between the sum of ώ-3 and whole brain FA, and the interaction between the right anterior limb of the internal capsule and the sum of ώ-3. The results confirm that certain fatty acids have a unique relationship with WM integrity in UHR individuals.
    Mesh-Begriff(e) Humans ; Psychotic Disorders/metabolism ; Psychotic Disorders/diagnostic imaging ; Psychotic Disorders/pathology ; Male ; Female ; Erythrocyte Membrane/metabolism ; Young Adult ; Adolescent ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Anisotropy ; White Matter/diagnostic imaging ; White Matter/pathology ; White Matter/metabolism ; Fatty Acids/metabolism ; Adult ; Diffusion Tensor Imaging ; Brain/diagnostic imaging ; Brain/metabolism ; Brain/pathology ; Docosahexaenoic Acids/metabolism ; Psychiatric Status Rating Scales ; Fatty Acids, Unsaturated/metabolism
    Chemische Substanzen Fatty Acids ; Docosahexaenoic Acids (25167-62-8) ; Fatty Acids, Unsaturated
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115966
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A Sequential Adaptive Intervention Strategy Targeting Remission and Functional Recovery in Young People at Ultrahigh Risk of Psychosis: The Staged Treatment in Early Psychosis (STEP) Sequential Multiple Assignment Randomized Trial.

    McGorry, Patrick D / Mei, Cristina / Amminger, G Paul / Yuen, Hok Pan / Kerr, Melissa / Spark, Jessica / Wallis, Nicky / Polari, Andrea / Baird, Shelley / Buccilli, Kate / Dempsey, Sarah-Jane A / Ferguson, Natalie / Formica, Melanie / Krcmar, Marija / Quinn, Amelia L / Mebrahtu, Yohannes / Ruslins, Arlan / Street, Rebekah / Wannan, Cassandra /
    Dixon, Lisa / Carter, Cameron / Loewy, Rachel / Niendam, Tara A / Shumway, Martha / Nelson, Barnaby

    JAMA psychiatry

    2023  Band 80, Heft 9, Seite(n) 875–885

    Abstract: Importance: Clinical trials have not established the optimal type, sequence, and duration of interventions for people at ultrahigh risk of psychosis.: Objective: To determine the effectiveness of a sequential and adaptive intervention strategy for ... ...

    Abstract Importance: Clinical trials have not established the optimal type, sequence, and duration of interventions for people at ultrahigh risk of psychosis.
    Objective: To determine the effectiveness of a sequential and adaptive intervention strategy for individuals at ultrahigh risk of psychosis.
    Design, setting, and participants: The Staged Treatment in Early Psychosis (STEP) sequential multiple assignment randomized trial took place within the clinical program at Orygen, Melbourne, Australia. Individuals aged 12 to 25 years who were seeking treatment and met criteria for ultrahigh risk of psychosis according to the Comprehensive Assessment of At-Risk Mental States were recruited between April 2016 and January 2019. Of 1343 individuals considered, 342 were recruited.
    Interventions: Step 1: 6 weeks of support and problem solving (SPS); step 2: 20 weeks of cognitive-behavioral case management (CBCM) vs SPS; and step 3: 26 weeks of CBCM with fluoxetine vs CBCM with placebo with an embedded fast-fail option of ω-3 fatty acids or low-dose antipsychotic medication. Individuals who did not remit progressed through these steps; those who remitted received SPS or monitoring for up to 12 months.
    Main outcomes and measures: Global Functioning: Social and Role scales (primary outcome), Brief Psychiatric Rating Scale, Scale for the Assessment of Negative Symptoms, Montgomery-Åsberg Depression Rating Scale, quality of life, transition to psychosis, and remission and relapse rates.
    Results: The sample comprised 342 participants (198 female; mean [SD] age, 17.7 [3.1] years). Remission rates, reflecting sustained symptomatic and functional improvement, were 8.5%, 10.3%, and 11.4% at steps 1, 2, and 3, respectively. A total of 27.2% met remission criteria at any step. Relapse rates among those who remitted did not significantly differ between SPS and monitoring (step 1: 65.1% vs 58.3%; step 2: 37.7% vs 47.5%). There was no significant difference in functioning, symptoms, and transition rates between SPS and CBCM and between CBCM with fluoxetine and CBCM with placebo. Twelve-month transition rates to psychosis were 13.5% (entire sample), 3.3% (those who ever remitted), and 17.4% (those with no remission).
    Conclusions and relevance: In this sequential multiple assignment randomized trial, transition rates to psychosis were moderate, and remission rates were lower than expected, partly reflecting the ambitious criteria set and challenges with real-world treatment fidelity and adherence. While all groups showed mild to moderate functional and symptomatic improvement, this was typically short of remission. While further adaptive trials that address these challenges are needed, findings confirm substantial and sustained morbidity and reveal relatively poor responsiveness to existing treatments.
    Trial registration: ClinicalTrials.gov Identifier: NCT02751632.
    Mesh-Begriff(e) Humans ; Female ; Adolescent ; Psychotic Disorders/diagnosis ; Fluoxetine/therapeutic use ; Quality of Life ; Antipsychotic Agents/therapeutic use ; Recurrence ; Treatment Outcome
    Chemische Substanzen Fluoxetine (01K63SUP8D) ; Antipsychotic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-07-12
    Erscheinungsland United States
    Dokumenttyp Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.1947
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Development of the PSYCHS

    The Accelerating Medicines Partnership Schizophrenia / Woods, Scott W. / Parker, Sophie / Kerr, Melissa J. / Walsh, Barbara C. / Wijtenburg, S. Andrea / Prunier, Nicholas / Nunez, Angela R. / Buccilli, Kate / Mourgues-Codern, Catalina / Brummitt, Kali / Kinney, Kyle S. / Trankler, Carli / Szacilo, Julia / Colton, Beau-Luke / Ali, Munaza / Haidar, Anastasia / Billah, Tashrif / Huynh, Kevin /
    Ahmed, Uzair / Adery, Laura L. / Marcy, Patricia J. / Allott, Kelly / Amminger, Paul / Arango, Celso / Broome, Matthew R.

    Early Intervention in Psychiatry

    Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

    2024  Band 18, Heft 4, Seite(n) 255–272

    Abstract: Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental ... ...

    Titelübersetzung Entwicklung des PSYCHS: Positive Symptome und diagnostische Kriterien für das CAARMS, harmonisiert mit dem SIPS
    Abstract Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS). Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences. Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR-P criteria. The semi-structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS. Conclusions: Using the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.
    Schlagwörter Diagnostic Criteria ; Diagnostische Kriterien ; Halbstrukturiertes Interview ; Krankheitsschweregrad ; Positiv- und Negativsymptomatik ; Positive and Negative Symptoms ; Psychodiagnosis ; Psychodiagnostik ; Psychose ; Psychosis ; Risikoerfassung ; Risk Assessment ; Semi-Structured Interview ; Severity (Disorders)
    Sprache Englisch
    Dokumenttyp Artikel
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13457
    Datenquelle PSYNDEX

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  6. Artikel: Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS.

    Woods, Scott W / Parker, Sophie / Kerr, Melissa J / Walsh, Barbara C / Wijtenburg, S Andrea / Prunier, Nicholas / Nunez, Angela R / Buccilli, Kate / Mourgues-Codern, Catalina / Brummitt, Kali / Kinney, Kyle S / Trankler, Carli / Szacilo, Julia / Colton, Beau-Luke / Ali, Munaza / Haidar, Anastasia / Billah, Tashrif / Huynh, Kevin / Ahmed, Uzair /
    Adery, Laura L / Corcoran, Cheryl M / Perkins, Diana O / Schiffman, Jason / Perez, Jesus / Mamah, Daniel / Ellman, Lauren M / Powers, Albert R / Coleman, Michael J / Anticevic, Alan / Fusar-Poli, Paolo / Kane, John M / Kahn, Rene S / McGorry, Patrick D / Bearden, Carrie E / Shenton, Martha E / Nelson, Barnaby / Calkins, Monica E / Hendricks, Larry / Bouix, Sylvain / Addington, Jean / McGlashan, Thomas H / Yung, Alison R

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental ... ...

    Abstract Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS).
    Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences.
    Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and partial harmonization for CHR-P criteria. The semi-structured interview, named P ositive SY mptoms and Diagnostic Criteria for the C AARMS H armonized with the S IPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS.
    Conclusion: Using the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.
    Sprache Englisch
    Erscheinungsdatum 2023-05-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.04.29.23289226
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS.

    Woods, Scott W / Parker, Sophie / Kerr, Melissa J / Walsh, Barbara C / Wijtenburg, S Andrea / Prunier, Nicholas / Nunez, Angela R / Buccilli, Kate / Mourgues-Codern, Catalina / Brummitt, Kali / Kinney, Kyle S / Trankler, Carli / Szacilo, Julia / Colton, Beau-Luke / Ali, Munaza / Haidar, Anastasia / Billah, Tashrif / Huynh, Kevin / Ahmed, Uzair /
    Adery, Laura L / Marcy, Patricia J / Allott, Kelly / Amminger, Paul / Arango, Celso / Broome, Matthew R / Cadenhead, Kristin S / Chen, Eric Y H / Choi, Jimmy / Conus, Philippe / Cornblatt, Barbara A / Glenthøj, Louise Birkedal / Horton, Leslie E / Kambeitz, Joseph / Kapur, Tina / Keshavan, Matcheri S / Koutsouleris, Nikolaos / Langbein, Kerstin / Lavoie, Suzie / Diaz-Caneja, Covadonga Martinez / Mathalon, Daniel H / Mittal, Vijay A / Nordentoft, Merete / Pasternak, Ofer / Pearlson, Godfrey D / Gaspar, Pablo A / Shah, Jai L / Smesny, Stefan / Stone, William S / Strauss, Gregory P / Wang, Jijun / Corcoran, Cheryl M / Perkins, Diana O / Schiffman, Jason / Perez, Jesus / Mamah, Daniel / Ellman, Lauren M / Powers, Albert R / Coleman, Michael J / Anticevic, Alan / Fusar-Poli, Paolo / Kane, John M / Kahn, Rene S / McGorry, Patrick D / Bearden, Carrie E / Shenton, Martha E / Nelson, Barnaby / Calkins, Monica E / Hendricks, Larry / Bouix, Sylvain / Addington, Jean / McGlashan, Thomas H / Yung, Alison R

    Early intervention in psychiatry

    2023  Band 18, Heft 4, Seite(n) 255–272

    Abstract: Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental ... ...

    Abstract Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS).
    Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences.
    Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR-P criteria. The semi-structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS.
    Conclusions: Using the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.
    Mesh-Begriff(e) Humans ; Psychiatric Status Rating Scales ; Psychotic Disorders/diagnosis ; Prodromal Symptoms
    Sprache Englisch
    Erscheinungsdatum 2023-08-28
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13457
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.

    Wannan, Cassandra M J / Nelson, Barnaby / Addington, Jean / Allott, Kelly / Anticevic, Alan / Arango, Celso / Baker, Justin T / Bearden, Carrie E / Billah, Tashrif / Bouix, Sylvain / Broome, Matthew R / Buccilli, Kate / Cadenhead, Kristin S / Calkins, Monica E / Cannon, Tyrone D / Cecci, Guillermo / Chen, Eric Yu Hai / Cho, Kang Ik K / Choi, Jimmy /
    Clark, Scott R / Coleman, Michael J / Conus, Philippe / Corcoran, Cheryl M / Cornblatt, Barbara A / Diaz-Caneja, Covadonga M / Dwyer, Dominic / Ebdrup, Bjørn H / Ellman, Lauren M / Fusar-Poli, Paolo / Galindo, Liliana / Gaspar, Pablo A / Gerber, Carla / Glenthøj, Louise Birkedal / Glynn, Robert / Harms, Michael P / Horton, Leslie E / Kahn, René S / Kambeitz, Joseph / Kambeitz-Ilankovic, Lana / Kane, John M / Kapur, Tina / Keshavan, Matcheri S / Kim, Sung-Wan / Koutsouleris, Nikolaos / Kubicki, Marek / Kwon, Jun Soo / Langbein, Kerstin / Lewandowski, Kathryn E / Light, Gregory A / Mamah, Daniel / Marcy, Patricia J / Mathalon, Daniel H / McGorry, Patrick D / Mittal, Vijay A / Nordentoft, Merete / Nunez, Angela / Pasternak, Ofer / Pearlson, Godfrey D / Perez, Jesus / Perkins, Diana O / Powers, Albert R / Roalf, David R / Sabb, Fred W / Schiffman, Jason / Shah, Jai L / Smesny, Stefan / Spark, Jessica / Stone, William S / Strauss, Gregory P / Tamayo, Zailyn / Torous, John / Upthegrove, Rachel / Vangel, Mark / Verma, Swapna / Wang, Jijun / Rossum, Inge Winter-van / Wolf, Daniel H / Wolff, Phillip / Wood, Stephen J / Yung, Alison R / Agurto, Carla / Alvarez-Jimenez, Mario / Amminger, Paul / Armando, Marco / Asgari-Targhi, Ameneh / Cahill, John / Carrión, Ricardo E / Castro, Eduardo / Cetin-Karayumak, Suheyla / Mallar Chakravarty, M / Cho, Youngsun T / Cotter, David / D'Alfonso, Simon / Ennis, Michaela / Fadnavis, Shreyas / Fonteneau, Clara / Gao, Caroline / Gupta, Tina / Gur, Raquel E / Gur, Ruben C / Hamilton, Holly K / Hoftman, Gil D / Jacobs, Grace R / Jarcho, Johanna / Ji, Jie Lisa / Kohler, Christian G / Lalousis, Paris Alexandros / Lavoie, Suzie / Lepage, Martin / Liebenthal, Einat / Mervis, Josh / Murty, Vishnu / Nicholas, Spero C / Ning, Lipeng / Penzel, Nora / Poldrack, Russell / Polosecki, Pablo / Pratt, Danielle N / Rabin, Rachel / Rahimi Eichi, Habiballah / Rathi, Yogesh / Reichenberg, Avraham / Reinen, Jenna / Rogers, Jack / Ruiz-Yu, Bernalyn / Scott, Isabelle / Seitz-Holland, Johanna / Srihari, Vinod H / Srivastava, Agrima / Thompson, Andrew / Turetsky, Bruce I / Walsh, Barbara C / Whitford, Thomas / Wigman, Johanna T W / Yao, Beier / Yuen, Hok Pan / Ahmed, Uzair / Byun, Andrew Jin Soo / Chung, Yoonho / Do, Kim / Hendricks, Larry / Huynh, Kevin / Jeffries, Clark / Lane, Erlend / Langholm, Carsten / Lin, Eric / Mantua, Valentina / Santorelli, Gennarina / Ruparel, Kosha / Zoupou, Eirini / Adasme, Tatiana / Addamo, Lauren / Adery, Laura / Ali, Munaza / Auther, Andrea / Aversa, Samantha / Baek, Seon-Hwa / Bates, Kelly / Bathery, Alyssa / Bayer, Johanna M M / Beedham, Rebecca / Bilgrami, Zarina / Birch, Sonia / Bonoldi, Ilaria / Borders, Owen / Borgatti, Renato / Brown, Lisa / Bruna, Alejandro / Carrington, Holly / Castillo-Passi, Rolando I / Chen, Justine / Cheng, Nicholas / Ching, Ann Ee / Clifford, Chloe / Colton, Beau-Luke / Contreras, Pamela / Corral, Sebastián / Damiani, Stefano / Done, Monica / Estradé, Andrés / Etuka, Brandon Asika / Formica, Melanie / Furlan, Rachel / Geljic, Mia / Germano, Carmela / Getachew, Ruth / Goncalves, Mathias / Haidar, Anastasia / Hartmann, Jessica / Jo, Anna / John, Omar / Kerins, Sarah / Kerr, Melissa / Kesselring, Irena / Kim, Honey / Kim, Nicholas / Kinney, Kyle / Krcmar, Marija / Kotler, Elana / Lafanechere, Melanie / Lee, Clarice / Llerena, Joshua / Markiewicz, Christopher / Matnejl, Priya / Maturana, Alejandro / Mavambu, Aissata / Mayol-Troncoso, Rocío / McDonnell, Amelia / McGowan, Alessia / McLaughlin, Danielle / McIlhenny, Rebecca / McQueen, Brittany / Mebrahtu, Yohannes / Mensi, Martina / Hui, Christy Lai Ming / Suen, Yi Nam / Wong, Stephanie Ming Yin / Morrell, Neal / Omar, Mariam / Partridge, Alice / Phassouliotis, Christina / Pichiecchio, Anna / Politi, Pierluigi / Porter, Christian / Provenzani, Umberto / Prunier, Nicholas / Raj, Jasmine / Ray, Susan / Rayner, Victoria / Reyes, Manuel / Reynolds, Kate / Rush, Sage / Salinas, Cesar / Shetty, Jashmina / Snowball, Callum / Tod, Sophie / Turra-Fariña, Gabriel / Valle, Daniela / Veale, Simone / Whitson, Sarah / Wickham, Alana / Youn, Sarah / Zamorano, Francisco / Zavaglia, Elissa / Zinberg, Jamie / Woods, Scott W / Shenton, Martha E

    Schizophrenia bulletin

    2024  Band 50, Heft 3, Seite(n) 496–512

    Abstract: This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of ... ...

    Abstract This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.
    Mesh-Begriff(e) Humans ; Psychotic Disorders ; Schizophrenia ; Prospective Studies ; Adult ; Prodromal Symptoms ; Young Adult ; International Cooperation ; Adolescent ; Research Design/standards ; Male ; Female
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbae011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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