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  1. Artikel ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19-authors' reply to Kawada T.

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    2021  Band 63, Heft 6, Seite(n) 835–836

    Mesh-Begriff(e) COVID-19 ; Humans ; Intracranial Aneurysm/diagnostic imaging ; SARS-CoV-2 ; Subarachnoid Hemorrhage/diagnostic imaging ; Vasospasm, Intracranial
    Sprache Englisch
    Erscheinungsdatum 2021-04-17
    Erscheinungsland Germany
    Dokumenttyp Letter ; Comment
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-021-02712-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19.

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    2020  Band 63, Heft 1, Seite(n) 149–152

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of nonaneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    Mesh-Begriff(e) Aged ; COVID-19/complications ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/etiology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-28
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-020-02535-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of nonaneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #734112
    Datenquelle COVID19

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  4. Artikel ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Harrogate , S , Mortimer , A , Burrows , L , Fiddes , B , Thomas , I & Rice , C M 2020 , ' Non-aneurysmal subarachnoid haemorrhage in COVID-19 ' , Neuroradiology . https://doi.org/10.1007/s00234-020-02535-4

    2020  

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hyper-coagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage have also been reported. We present two cases of non- ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hyper-coagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage have also been reported. We present two cases of non-aneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    Schlagwörter /dk/atira/pure/core/keywords/uob_covid19 ; Covid19 ; subarachnoid haemorrhage ; COVID-19 ; clinical neurology ; neuroradiology ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 ; Journal Article ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-28
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology ; ISSN 0028-3940 1432-1920

    2020  

    Schlagwörter Radiology Nuclear Medicine and imaging ; Clinical Neurology ; Cardiology and Cardiovascular Medicine ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1007/s00234-020-02535-4
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Public health engagement: detection of suspicious skin lesions, screening and referral behaviour of UK based chiropractors.

    Glithro, Sara / Newell, David / Burrows, Lorna / Hunnisett, Adrian / Cunliffe, Christina

    Chiropractic & manual therapies

    2015  Band 23, Heft 1, Seite(n) 5

    Abstract: Background: UK morbidity and mortality rates from skin cancer are increasing despite existing preventative strategies involving education and early detection. Manual therapists are ideally placed to support these goals as they see greater quantities of ... ...

    Abstract Background: UK morbidity and mortality rates from skin cancer are increasing despite existing preventative strategies involving education and early detection. Manual therapists are ideally placed to support these goals as they see greater quantities of exposed patient skin more often than most other healthcare professionals. The purpose of this study therefore was to ascertain the ability of manual therapists to detect, screen and refer suspicious skin lesions.
    Method: A web-based questionnaire and quiz was used in a sample of UK chiropractic student clinicians and registered chiropractors to gather data during 2011 concerning skin screening and referral behaviors for suspicious skin lesions.
    Results: A total of 120 questionnaires were included. Eighty one percent of participants agreed that screening for suspicious skin lesions was part of their clinical role, with nearly all (94%) assessing their patients for lesions during examination. Over 90% of the participants reported regularly having the opportunity for skin examination; with nearly all (98%) agreeing they would refer patients with suspicious skin lesions to a medical practitioner. A third of respondents had referred a total of 80 suspicious lesions within the last 12 months with 67% warranting further investigation.
    Conclusions: Nearly all respondents agreed that screening patients for suspicious skin lesions was part of their clinical role, with a significant number already referring patients with lesions.
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2590836-4
    ISSN 2045-709X
    ISSN 2045-709X
    DOI 10.1186/s12998-014-0047-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Studies into the Mechanisms of Dermal Inflammation Using Cutaneous Microdialysis

    Church, Martin K. / Bewley, Anthony P. / Clough, Geraldine F. / Burrows, Lorna J. / Ferdinand, Sandra I. / Petersen, Lars J.

    International Archives of Allergy and Immunology

    1997  Band 113, Heft 1-3, Seite(n) 131–133

    Schlagwörter Microdialysis ; Skin ; Histamine ; Bradykinin ; Cetirizine
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000237526
    Datenquelle Karger Verlag

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  8. Artikel ; Online: Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial.

    Corrie, P G / Marshall, A / Nathan, P D / Lorigan, P / Gore, M / Tahir, S / Faust, G / Kelly, C G / Marples, M / Danson, S J / Marshall, E / Houston, S J / Board, R E / Waterston, A M / Nobes, J P / Harries, M / Kumar, S / Goodman, A / Dalgleish, A /
    Martin-Clavijo, A / Westwell, S / Casasola, R / Chao, D / Maraveyas, A / Patel, P M / Ottensmeier, C H / Farrugia, D / Humphreys, A / Eccles, B / Young, G / Barker, E O / Harman, C / Weiss, M / Myers, K A / Chhabra, A / Rodwell, S H / Dunn, J A / Middleton, M R / Nathan, Paul / Lorigan, Paul / Dziewulski, Peter / Holikova, Sonja / Panwar, Udaiveer / Tahir, Saad / Faust, Guy / Thomas, Anne / Corrie, Pippa / Sirohi, Bhawna / Kelly, Charles / Middleton, Mark / Marples, Maria / Danson, Sarah / Lester, James / Marshall, Ernest / Ajaz, Mazhar / Houston, Stephen / Board, Ruth / Eaton, David / Waterston, Ashita / Nobes, Jenny / Loo, Suat / Gray, Gill / Stubbings, Helen / Gore, Martin / Harries, Mark / Kumar, Satish / Goodman, Andrew / Dalgleish, Angus / Martin-Clavijo, Agustin / Marsden, Jerry / Westwell, Sarah / Casasola, Richard / Chao, David / Maraveyas, Anthony / Patel, Poulam / Ottensmeier, Christian / Farrugia, David / Humphreys, Alison / Eccles, Bryony / Dega, Renata / Herbert, Chris / Price, Christopher / Brunt, Murray / Scott-Brown, Martin / Hamilton, Joanna / Hayward, Richard Larry / Smyth, John / Woodings, Pamela / Nayak, Neena / Burrows, Lorna / Wolstenholme, Virginia / Wagstaff, John / Nicolson, Marianne / Wilson, Andrew / Barlow, Clare / Scrase, Christopher / Podd, Timothy / Gonzalez, Michael / Stewart, John / Highley, Martin / Grumett, Simon / Talbot, Toby / Nathan, Kannon / Coltart, Robert / Gee, Bruce

    Annals of oncology : official journal of the European Society for Medical Oncology

    2018  Band 29, Heft 8, Seite(n) 1843–1852

    Abstract: Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of ... ...

    Abstract Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence.
    Patients and methods: Patients with resected AJCC stage IIB, IIC and III cutaneous melanoma were randomised to receive either adjuvant bevacizumab (7.5 mg/kg i.v. 3 weekly for 1 year) or standard observation. The primary end point was detection of an 8% difference in 5-year overall survival (OS) rate; secondary end points included disease-free interval (DFI) and distant metastasis-free interval (DMFI). Tumour and blood were analysed for prognostic and predictive markers.
    Results: Patients (n=1343) recruited between 2007 and 2012 were predominantly stage III (73%), with median age 56 years (range 18-88 years). With 6.4-year median follow-up, 515 (38%) patients had died [254 (38%) bevacizumab; 261 (39%) observation]; 707 (53%) patients had disease recurrence [336 (50%) bevacizumab, 371 (55%) observation]. OS at 5 years was 64% for both groups [hazard ratio (HR) 0.98; 95% confidence interval (CI) 0.82-1.16, P = 0.78). At 5 years, 51% were disease free on bevacizumab versus 45% on observation (HR 0.85; 95% CI 0.74-0.99, P = 0.03), 58% were distant metastasis free on bevacizumab versus 54% on observation (HR 0.91; 95% CI 0.78-1.07, P = 0.25). Forty four percent of 682 melanomas assessed had a BRAFV600 mutation. In the observation arm, BRAF mutant patients had a trend towards poorer OS compared with BRAF wild-type patients (P = 0.06). BRAF mutation positivity trended towards better OS with bevacizumab (P = 0.21).
    Conclusions: Adjuvant bevacizumab after resection of high-risk melanoma improves DFI, but not OS. BRAF mutation status may predict for poorer OS untreated and potential benefit from bevacizumab.
    Clinical trial information: ISRCTN 81261306; EudraCT Number: 2006-005505-64.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bevacizumab/administration & dosage ; Chemotherapy, Adjuvant/methods ; Dermatologic Surgical Procedures ; Disease-Free Survival ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Male ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Survival Analysis ; Time Factors ; Watchful Waiting ; Young Adult
    Chemische Substanzen Bevacizumab (2S9ZZM9Q9V) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2018-11-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdy229
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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