LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 61

Suchoptionen

  1. Artikel ; Online: Russian SARS-CoV-2 vaccine.

    Caddy, Sarah

    BMJ (Clinical research ed.)

    2020  Band 370, Seite(n) m3270

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; COVID-19 Vaccines ; Clinical Trials, Phase III as Topic ; Coronavirus Infections/prevention & control ; Evidence-Based Medicine ; Global Health ; Government Regulation ; Humans ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/prevention & control ; Risk ; Russia ; SARS-CoV-2 ; Viral Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Viral Vaccines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-24
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m3270
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Developing a vaccine for covid-19.

    Caddy, Sarah

    BMJ (Clinical research ed.)

    2020  Band 369, Seite(n) m1790

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Drug Design ; Drug Discovery ; Drug Repositioning ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/drug effects ; Viral Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-04
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1790
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Buch ; Online: Developing a vaccine for covid-19

    Caddy, Sarah

    2020  

    Schlagwörter EDITORIALS ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-04 07:55:29.0
    Verlag BMJ Publishing Group Ltd
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  4. Buch ; Online: Russian SARS-CoV-2 vaccine

    Caddy, Sarah

    2020  

    Schlagwörter EDITORIALS ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-24 04:06:02.0
    Verlag BMJ Publishing Group Ltd
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Russian SARS-CoV-2 vaccine

    Caddy, Sarah

    BMJ

    2020  , Seite(n) m3270

    Schlagwörter covid19
    Sprache Englisch
    Verlag BMJ
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m3270
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Developing a vaccine for covid-19

    Caddy, Sarah

    BMJ

    2020  , Seite(n) m1790

    Schlagwörter covid19
    Sprache Englisch
    Verlag BMJ
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1790
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Virus neutralisation by intracellular antibodies.

    Bottermann, Maria / Caddy, Sarah L

    Seminars in cell & developmental biology

    2021  Band 126, Seite(n) 108–116

    Abstract: For decades antibodies were largely thought to provide protection in extracellular spaces alone, mediating their effector functions by mechanisms such as entry-blocking, complement activation and phagocyte recruitment. However, a wealth of research has ... ...

    Abstract For decades antibodies were largely thought to provide protection in extracellular spaces alone, mediating their effector functions by mechanisms such as entry-blocking, complement activation and phagocyte recruitment. However, a wealth of research has shown that antibodies are also capable of neutralising numerous viruses inside cells. Efficacy has now been demonstrated at virtually all intracellular stages of the viral life cycle. Antibodies can neutralise viruses in endosomes by blocking uncoating, fusion mechanisms, or new particle egress. Neutralisation can also occur in the cytosol via recruitment of the intracellular antibody receptor TRIM21. In addition to these direct neutralisation effects, recent research has shown that antibodies can mediate virus control indirectly by promoting MHC class I presentation and thereby increasing the CD8 T cell response. This provides valuable new insight into how non-neutralising antibodies can mediate potent protection in vivo. Overall, the importance of understanding the mechanisms of intracellular neutralisation by antibodies is highlighted by the ongoing need to develop new methods to control viruses. Using or inducing antibodies to block virus replication inside cells is now an innovative approach used by several vaccination and therapeutic strategies.
    Mesh-Begriff(e) Antibodies, Viral ; Complement Activation
    Chemische Substanzen Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2021-11-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.10.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel: Rotavirus research: 2014–2020

    Caddy, Sarah / Papa, Guido / Borodavka, Alexander / Desselberger, Ulrich

    Virus research. 2021 Oct. 15, v. 304

    2021  

    Abstract: Rotaviruses are major causes of acute gastroenteritis in infants and young children worldwide and also cause disease in the young of many other mammalian and of avian species. During the recent 5–6 years rotavirus research has benefitted in a major way ... ...

    Abstract Rotaviruses are major causes of acute gastroenteritis in infants and young children worldwide and also cause disease in the young of many other mammalian and of avian species. During the recent 5–6 years rotavirus research has benefitted in a major way from the establishment of plasmid only-based reverse genetics systems, the creation of human and other mammalian intestinal enteroids, and from the wide application of structural biology (cryo-electron microscopy, cryo-EM tomography) and complementary biophysical approaches. All of these have permitted to gain new insights into structure-function relationships of rotaviruses and their interactions with the host. This review follows different stages of the viral replication cycle and summarizes highlights of structure-function studies of rotavirus-encoded proteins (both structural and non-structural), molecular mechanisms of viral replication including involvement of cellular proteins and lipids, the spectrum of viral genomic and antigenic diversity, progress in understanding of innate and acquired immune responses, and further developments of prevention of rotavirus-associated disease.
    Schlagwörter Rotavirus ; antigenic variation ; birds ; cryo-electron microscopy ; gastroenteritis ; genomics ; humans ; intestines ; plasmids ; research ; reverse genetics ; structural biology ; tomography ; virus replication ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2021-1015
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2021.198499
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang