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  1. Artikel ; Online: Sensitization of Nd

    Durán-Hernández, Jesús / Muñoz-Rugeles, Leonardo / Guzmán-Méndez, Óscar / M Reza, Mariana / Cadena-Caicedo, Andrea / García-Montalvo, Verónica / Peón, Jorge

    The journal of physical chemistry. A

    2022  Band 126, Heft 16, Seite(n) 2498–2510

    Abstract: We have designed and synthesized two new cyaninic ... ...

    Abstract We have designed and synthesized two new cyaninic Nd
    Sprache Englisch
    Erscheinungsdatum 2022-04-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c01052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ultrafast Fluorescence Signals from β-Dihydronicotinamide Adenine Dinucleotide: Resonant Energy Transfer in the Folded and Unfolded Forms.

    Cadena-Caicedo, Andrea / Gonzalez-Cano, Beatriz / López-Arteaga, Rafael / Esturau-Escofet, Nuria / Peon, Jorge

    The journal of physical chemistry. B

    2020  Band 124, Heft 3, Seite(n) 519–530

    Abstract: β-Dihydronicotinamide adenine dinucleotide (NADH) plays a critical role in biological redox processes. Inside the cell, NADH can be in a folded or an unfolded conformation, depending on the chemical environment that surrounds it. It is known that ... ...

    Abstract β-Dihydronicotinamide adenine dinucleotide (NADH) plays a critical role in biological redox processes. Inside the cell, NADH can be in a folded or an unfolded conformation, depending on the chemical environment that surrounds it. It is known that selective excitation of adenine in NADH can induce energy transfer events from this nucleotide to the reduced nicotinamide chromophore. From the anticipated time scales, this process must compete with adenine's internal conversion channel, which is known to occur in the sub-picosecond time scale. In this work, we studied the dynamics of the excited states of both chromophores in NADH through the time resolution of the spontaneous emission from both nucleotides. Through these experiments, we extend the knowledge about the competition between the different photophysical channels both in the folded and unfolded states. The study involved the folded and unfolded states of NADH by experiments in water and methanol solutions. Our femtosecond fluorescence results were complemented by the first nuclear magnetic resonance through space magnetization transfer measurements on NADH, which establish the solvent-dependent folded versus unfolded states. We determined the dynamics of the excited states by direct excitation of dihydronicotinamide at 380 nm and adenine at 266 nm. From this, we were able to measure for the folded state, a time constant of 90 fs for energy transfer. Additionally, we determined that even in what is referred to as an unfolded state in methanol, non-negligible excitation transfer events do take place. Spontaneous emission anisotropy measurements were used in order to confirm the presence of a minor energy transfer channel in the methanol solutions where the unfolded state dominates.
    Mesh-Begriff(e) Adenosine Monophosphate/chemistry ; Anisotropy ; Energy Transfer ; Fluorescence ; Methanol/chemistry ; Molecular Conformation ; NAD/analogs & derivatives ; NAD/chemistry ; Proton Magnetic Resonance Spectroscopy ; Spectrometry, Fluorescence ; Water/chemistry
    Chemische Substanzen 1-benzyl-1,4-dihydronicotinamide ; Water (059QF0KO0R) ; NAD (0U46U6E8UK) ; Adenosine Monophosphate (415SHH325A) ; Methanol (Y4S76JWI15)
    Sprache Englisch
    Erscheinungsdatum 2020-01-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.9b10012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Primary Photophysics of Nicotinamide Chromophores in Their Oxidized and Reduced Forms.

    Reza, Mariana M / Durán-Hernández, Jesús / González-Cano, Beatriz / Jara-Cortés, Jesús / López-Arteaga, Rafael / Cadena-Caicedo, Andrea / Muñoz-Rugeles, Leonardo / Hernández-Trujillo, Jesús / Peon, Jorge

    The journal of physical chemistry. B

    2023  Band 127, Heft 39, Seite(n) 8432–8445

    Abstract: Nicotinamide adenine dinucleotide (NADH) is an important enzyme cofactor with emissive properties that allow it to be used in fluorescence microscopies to study cell metabolism. Its oxidized form ... ...

    Abstract Nicotinamide adenine dinucleotide (NADH) is an important enzyme cofactor with emissive properties that allow it to be used in fluorescence microscopies to study cell metabolism. Its oxidized form NAD
    Sprache Englisch
    Erscheinungsdatum 2023-09-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c03246
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Ultrafast Fluorescence Signals from β-Dihydronicotinamide Adenine Dinucleotide: Resonant Energy Transfer in the Folded and Unfolded Forms

    Cadena-Caicedo, Andrea / Gonzalez-Cano, Beatriz / López-Arteaga, Rafael / Esturau-Escofet, Nuria / Peon, Jorge

    Journal of physical chemistry. 2019 Dec. 26, v. 124, no. 3

    2019  

    Abstract: β-Dihydronicotinamide adenine dinucleotide (NADH) plays a critical role in biological redox processes. Inside the cell, NADH can be in a folded or an unfolded conformation, depending on the chemical environment that surrounds it. It is known that ... ...

    Abstract β-Dihydronicotinamide adenine dinucleotide (NADH) plays a critical role in biological redox processes. Inside the cell, NADH can be in a folded or an unfolded conformation, depending on the chemical environment that surrounds it. It is known that selective excitation of adenine in NADH can induce energy transfer events from this nucleotide to the reduced nicotinamide chromophore. From the anticipated time scales, this process must compete with adenine’s internal conversion channel, which is known to occur in the sub-picosecond time scale. In this work, we studied the dynamics of the excited states of both chromophores in NADH through the time resolution of the spontaneous emission from both nucleotides. Through these experiments, we extend the knowledge about the competition between the different photophysical channels both in the folded and unfolded states. The study involved the folded and unfolded states of NADH by experiments in water and methanol solutions. Our femtosecond fluorescence results were complemented by the first nuclear magnetic resonance through space magnetization transfer measurements on NADH, which establish the solvent-dependent folded versus unfolded states. We determined the dynamics of the excited states by direct excitation of dihydronicotinamide at 380 nm and adenine at 266 nm. From this, we were able to measure for the folded state, a time constant of 90 fs for energy transfer. Additionally, we determined that even in what is referred to as an unfolded state in methanol, non-negligible excitation transfer events do take place. Spontaneous emission anisotropy measurements were used in order to confirm the presence of a minor energy transfer channel in the methanol solutions where the unfolded state dominates.
    Schlagwörter NAD (coenzyme) ; adenine ; anisotropy ; energy transfer ; fluorescence ; methanol ; nicotinamide ; nuclear magnetic resonance spectroscopy ; physical chemistry
    Sprache Englisch
    Erscheinungsverlauf 2019-1226
    Umfang p. 519-530.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1520-5207
    DOI 10.1021/acs.jpcb.9b10012
    Datenquelle NAL Katalog (AGRICOLA)

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