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  1. Artikel ; Online: Kai-xin-san improves cognitive impairment in D-gal and Aβ

    Wang, Huijuan / Zhou, Lifen / Zheng, Qin / Song, Yonggui / Huang, Weihua / Yang, Lin / Xiong, Yongchang / Cai, Zhinan / Chen, Ying / Yuan, Jinbin

    Journal of ethnopharmacology

    2024  Band 329, Seite(n) 118161

    Abstract: Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic herbal formula for the treatment and prevention of AD (Alzheimer's disease) with definite curative effect, but its mechanism, which involves multiple components, pathways, and targets, is ... ...

    Abstract Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic herbal formula for the treatment and prevention of AD (Alzheimer's disease) with definite curative effect, but its mechanism, which involves multiple components, pathways, and targets, is not yet fully understood.
    Aim of the study: To verify the effect of KXS on gut microbiota and explore its anti-AD mechanism related with gut microbiota.
    Materials and methods: AD rat model was established and evaluated by intraperitoneal injection of D-gal and bilateral hippocampal CA1 injections of Aβ
    Results: KXS could significantly improve cognitive impairment, reduce neuronal damage and attenuate neuroinflammation and colonic inflammation in vivo in AD model rats. Nine differential intestinal bacteria associated with AD were screened, in which four bacteria (Lactobacillus murinus, Ligilactobacillus, Alloprevotella, Prevotellaceae_NK3B31_group) were very significant.
    Conclusion: KXS can maintain the ecological balance of intestinal microbiota and exert its anti-AD effect by regulating the composition and proportion of gut microbiota in AD rats through the microbiota-gut-brain axis.
    Mesh-Begriff(e) Animals ; Gastrointestinal Microbiome/drug effects ; Drugs, Chinese Herbal/pharmacology ; Male ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/chemically induced ; Peptide Fragments ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/chemically induced ; Rats ; Neurons/drug effects ; Rats, Sprague-Dawley ; Disease Models, Animal ; Fecal Microbiota Transplantation ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Morris Water Maze Test/drug effects
    Chemische Substanzen Drugs, Chinese Herbal ; Peptide Fragments ; Amyloid beta-Peptides ; amyloid beta-protein (25-35) ; Kai-Xin-San
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118161
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Online: Task-related self-supervised learning for remote sensing image change detection

    Cai, Zhinan / Jiang, Zhiyu / Yuan, Yuan

    2021  

    Abstract: Change detection for remote sensing images is widely applied for urban change detection, disaster assessment and other fields. However, most of the existing CNN-based change detection methods still suffer from the problem of inadequate pseudo-changes ... ...

    Abstract Change detection for remote sensing images is widely applied for urban change detection, disaster assessment and other fields. However, most of the existing CNN-based change detection methods still suffer from the problem of inadequate pseudo-changes suppression and insufficient feature representation. In this work, an unsupervised change detection method based on Task-related Self-supervised Learning Change Detection network with smooth mechanism(TSLCD) is proposed to eliminate it. The main contributions include: (1) the task-related self-supervised learning module is introduced to extract spatial features more effectively. (2) a hard-sample-mining loss function is applied to pay more attention to the hard-to-classify samples. (3) a smooth mechanism is utilized to remove some of pseudo-changes and noise. Experiments on four remote sensing change detection datasets reveal that the proposed TSLCD method achieves the state-of-the-art for change detection task.

    Comment: IEEE ICASSP 2021
    Schlagwörter Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2021-05-11
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Dual-sensing porphyrin-containing copolymer nanosensor as full-spectrum colorimeter and ultra-sensitive thermometer

    Yan, Qiang / Cai, Zhinan / Kang, Yan / Yin, Yingwu / Yuan, Jinying / Zhou, Lilin

    Chemical communications. 2010 Apr. 6, v. 46, no. 16

    2010  

    Abstract: A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the ... ...

    Abstract A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the sensor displays an “isothermal” thermochromic point as an ultra-sensitive thermometer.
    Schlagwörter chemical communication ; chemical reactions ; colorimetry ; composite polymers ; metal ions ; sensors (equipment) ; temperature ; thermometers
    Sprache Englisch
    Erscheinungsverlauf 2010-0406
    Umfang p. 2781-2783.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b926882k
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Dual-sensing porphyrin-containing copolymer nanosensor as full-spectrum colorimeter and ultra-sensitive thermometer.

    Yan, Qiang / Yuan, Jinying / Kang, Yan / Cai, Zhinan / Zhou, Lilin / Yin, Yingwu

    Chemical communications (Cambridge, England)

    2010  Band 46, Heft 16, Seite(n) 2781–2783

    Abstract: A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the ... ...

    Abstract A porphyrin-containing copolymer has dual-sensing in response to metal ions and temperature as a novel nanosensor. Triggered by ions, the sensor exhibits full-color tunable behavior as a cationic detector and colorimeter. Responding to temperature, the sensor displays an "isothermal" thermochromic point as an ultra-sensitive thermometer.
    Sprache Englisch
    Erscheinungsdatum 2010-04-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b926882k
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Voltage-responsive vesicles based on orthogonal assembly of two homopolymers.

    Yan, Qiang / Yuan, Jinying / Cai, Zhinan / Xin, Yan / Kang, Yan / Yin, Yingwu

    Journal of the American Chemical Society

    2010  Band 132, Heft 27, Seite(n) 9268–9270

    Abstract: Two end-decorated homopolymers, poly(styrene)-beta-cyclodextrin (PS-beta-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-beta-CD/PEO-Fc) in aqueous solutions based on the ... ...

    Abstract Two end-decorated homopolymers, poly(styrene)-beta-cyclodextrin (PS-beta-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-beta-CD/PEO-Fc) in aqueous solutions based on the terminal host-guest interactions. These assemblies can further form supramolecular vesicles, and their assembly and disassembly behaviors can be reversibly switched by voltage through the reversible association and disassociation of the middle supramolecular connection. The vesicles possess an unprecedented property that their assembly or disassembly speed can be controlled by the applied voltage strength. Luminescence spectroscopy demonstrates that the vesicles act as nanocapsules carrying molecules within their hollow cavities and that the external voltage strength accurately regulates the drug release time.
    Mesh-Begriff(e) Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Electric Capacitance ; Ferrous Compounds ; Luminescent Measurements ; Metallocenes ; Nanocapsules/chemistry ; Polyethylene Glycols ; Polymers/chemistry ; Polystyrenes ; beta-Cyclodextrins
    Chemische Substanzen Drug Carriers ; Ferrous Compounds ; Metallocenes ; Nanocapsules ; Polymers ; Polystyrenes ; beta-Cyclodextrins ; Polyethylene Glycols (30IQX730WE) ; betadex (JV039JZZ3A) ; ferrocene (U96PKG90JQ)
    Sprache Englisch
    Erscheinungsdatum 2010-07-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/ja1027502
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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