Artikel ; Online: Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE): A pilot trial.
Cell reports. Medicine
2021 Band 2, Heft 5, Seite(n) 100280
Abstract: Case fatality among African children with severe acute malnutrition remains high. We report a 3-arm pilot trial in 58 Ugandan children, comparing feeds targeting disordered gastrointestinal function containing cowpea (CpF, n = 20) or inulin (InF, n = 20) ...
Abstract | Case fatality among African children with severe acute malnutrition remains high. We report a 3-arm pilot trial in 58 Ugandan children, comparing feeds targeting disordered gastrointestinal function containing cowpea (CpF, n = 20) or inulin (InF, n = 20) with conventional feeds (ConF, n = 18). Baseline measurements of gut permeability (lactulose:mannitol ratio 1.19 ± SD 2.00), inflammation (fecal calprotectin 539.0 μg/g, interquartile range [IQR] 904.8), and satiety (plasma polypeptide YY 62.6 pmol/l, IQR 110.3) confirm gastrointestinal dysfunction. By day 28, no differences are observable in proportion achieving weight gain >5 g/kg/day (87%, 92%, 86%; p > 0.05), mortality (16%, 30%, 17%; p > 0.05), or edema resolution (83%, 54%, 91%; p > 0.05) among CpF, InF, and ConF. Decreased fecal bacterial richness from day 1 (abundance-based coverage estimator [ACE] 53.2) to day 7 (ACE 40.8) is observed only in ConF (p = 0.025). |
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Mesh-Begriff(e) | Bacteria/drug effects ; Child ; Child, Preschool ; Fabaceae ; Feces/microbiology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Humans ; Infant ; Leukocyte L1 Antigen Complex/physiology ; Malnutrition/etiology ; Microbiota/genetics ; Microbiota/immunology ; Permeability ; Pilot Projects ; RNA, Ribosomal, 16S/drug effects ; RNA, Ribosomal, 16S/genetics |
Chemische Substanzen | Leukocyte L1 Antigen Complex ; RNA, Ribosomal, 16S |
Sprache | Englisch |
Erscheinungsdatum | 2021-05-18 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 2666-3791 |
ISSN (online) | 2666-3791 |
DOI | 10.1016/j.xcrm.2021.100280 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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