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  1. Artikel: Neurovascular Mechanisms of Cognitive Aging: Sex-Related Differences in the Average Progression of Arteriosclerosis, White Matter Atrophy, and Cognitive Decline.

    Bowie, Daniel C / Low, Kathy A / Rubenstein, Samantha L / Islam, Samia S / Zimmerman, Benjamin / Camacho, Paul B / Sutton, Bradley P / Gratton, Gabriele / Fabiani, Monica

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Arterial stiffness (arteriosclerosis) has been linked to heightened risks for cognitive decline, and ultimately for Alzheimer's disease and other forms of dementia. Importantly, neurovascular outcomes generally vary according to one's biological sex. ... ...

    Abstract Arterial stiffness (arteriosclerosis) has been linked to heightened risks for cognitive decline, and ultimately for Alzheimer's disease and other forms of dementia. Importantly, neurovascular outcomes generally vary according to one's biological sex. Here, capitalizing on a large sample of participants with neuroimaging and behavioral data (
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.09.06.556562
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline.

    Cai, Lanya T / Moon, Joseph / Camacho, Paul B / Anderson, Aaron T / Chwa, Won Jong / Sutton, Bradley P / Markowitz, Amy J / Palacios, Eva M / Rodriguez, Alexis / Manley, Geoffrey T / Shankar, Shivsundaram / Bremer, Peer-Timo / Mukherjee, Pratik / Madduri, Ravi K

    Neuroinformatics

    2024  Band 22, Heft 2, Seite(n) 177–191

    Abstract: Large-scale diffusion MRI tractography remains a significant challenge. Users must orchestrate a complex sequence of instructions that requires many software packages with complex dependencies and high computational costs. We developed MaPPeRTrac, an ... ...

    Abstract Large-scale diffusion MRI tractography remains a significant challenge. Users must orchestrate a complex sequence of instructions that requires many software packages with complex dependencies and high computational costs. We developed MaPPeRTrac, an edge-centric tractography pipeline that simplifies and accelerates this process in a wide range of high-performance computing (HPC) environments. It fully automates either probabilistic or deterministic tractography, starting from a subject's magnetic resonance imaging (MRI) data, including structural and diffusion MRI images, to the edge density image (EDI) of their structural connectomes. Dependencies are containerized with Singularity (now called Apptainer) and decoupled from code to enable rapid prototyping and modification. Data derivatives are organized with the Brain Imaging Data Structure (BIDS) to ensure that they are findable, accessible, interoperable, and reusable following FAIR principles. The pipeline takes full advantage of HPC resources using the Parsl parallel programming framework, resulting in the creation of connectome datasets of unprecedented size. MaPPeRTrac is publicly available and tested on commercial and scientific hardware, so it can accelerate brain connectome research for a broader user community. MaPPeRTrac is available at: https://github.com/LLNL/mappertrac .
    Mesh-Begriff(e) Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Connectome/methods
    Sprache Englisch
    Erscheinungsdatum 2024-03-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2111941-7
    ISSN 1559-0089 ; 1539-2791
    ISSN (online) 1559-0089
    ISSN 1539-2791
    DOI 10.1007/s12021-024-09650-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Yoga, aerobic and stretching exercise effects on neurocognition: Randomized controlled trial protocol.

    Gothe, Neha P / Erlenbach, Emily / Garcia, Veronica / Malani, Revati / Voss, Stephanie / Camacho, Paul B / McAuley, Edward / Burd, Nicholas / Sutton, Bradley P / Damoiseaux, Jessica S

    Contemporary clinical trials

    2023  Band 131, Seite(n) 107240

    Abstract: As the global population ages, the prevalence of cognitive decline and dementia is expected to rise, creating a significant health and economic burden. The purpose of this trial is to rigorously test, for the first time, the efficacy of yoga training as ... ...

    Abstract As the global population ages, the prevalence of cognitive decline and dementia is expected to rise, creating a significant health and economic burden. The purpose of this trial is to rigorously test, for the first time, the efficacy of yoga training as a physical activity intervention to mitigate age-related cognitive decline and impairment. We are conducting a 6-month randomized controlled trial (RCT) of exercise among 168 middle aged and older adults to compare the efficacy of yoga vs. aerobic exercise on cognitive function, brain structure and function, cardiorespiratory fitness, and circulating inflammatory and molecular markers. Using a single-blind, three arm RCT, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or a stretching-toning active control group. Participants will engage in hour long group exercise 3x/week for 6-months. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. Our primary outcomes of interest are brain regions, such as hippocampal volume and prefrontal cortex, and cognitive functions, such as episodic memory, working memory and executive functions, that are typically affected by aging and Alzheimer's disease. Not only will this RCT test whether yoga is a means to mitigate age-related cognitive decline, but it may also offer an alternative to aerobic exercise, which could be particularly appealing to older adults with compromised physical functioning. ClinicalTrials.gov Identifier: NCT04323163.
    Mesh-Begriff(e) Middle Aged ; Humans ; Aged ; Yoga ; Exercise/psychology ; Cognition ; Executive Function ; Alzheimer Disease ; Exercise Therapy/methods ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-05-25
    Erscheinungsland United States
    Dokumenttyp Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2023.107240
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1581: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Artikel: Voluntary Saccade Training Protocol in Persons With Parkinson's Disease and Healthy Adults.

    Camacho, Paul B / Carbonari, Ronald / Shen, Sa / Zadikoff, Cindy / Kramer, Arthur F / López-Ortiz, Citlali

    Frontiers in aging neuroscience

    2019  Band 11, Seite(n) 77

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2019-04-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2019.00077
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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