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  1. Article ; Online: Use TRIPOD when validating clinical prediction models.

    Candel, Bart Gj / Nissen, Søren Kabell

    Emergency medicine journal : EMJ

    2022  Volume 40, Issue 1, Page(s) 81

    MeSH term(s) Humans ; Prognosis ; Models, Statistical ; Decision Support Techniques ; Checklist ; Triage ; Emergency Service, Hospital
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2022-212617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex differences in clinical presentation and risk stratification in the Emergency Department: An observational multicenter cohort study.

    Candel, Bart Gj / Dap, Saimi / Raven, Wouter / Lameijer, Heleen / Gaakeer, Menno I / de Jonge, Evert / de Groot, Bas

    European journal of internal medicine

    2021  Volume 95, Page(s) 74–79

    Abstract: Objective: The aim of this study was to investigate whether sex differences exist in disease presentations, disease severity and (case-mix adjusted) outcomes in the Emergency Department (ED).: Methods: Observational multicenter cohort study using the ...

    Abstract Objective: The aim of this study was to investigate whether sex differences exist in disease presentations, disease severity and (case-mix adjusted) outcomes in the Emergency Department (ED).
    Methods: Observational multicenter cohort study using the Netherlands Emergency Department Evaluation Database (NEED), including patients ≥ 18 years of three Dutch EDs. Multivariable logistic regression was used to study the associations between sex and outcome measures in-hospital mortality and Intensive Care Unit/Medium Care Unit (ICU/MCU) admission in ED patients and in subgroups triage categories and presenting complaints.
    Results: Of 148,825 patients, 72,554 (48.8%) were females. Patient characteristics at ED presentation and diagnoses (such as pneumonia, cerebral infarction, and fractures) were comparable between sexes at ED presentation. In-hospital mortality was 2.2% in males and 1.7% in females. ICU/MCU admission was 4.7% in males and 3.1% in females. Males had higher unadjusted (OR 1.34(1.25-1.45)) and adjusted (AOR 1.34(1.24-1.46)) risks for mortality, and unadjusted (OR 1.54(1.46-1.63)) and adjusted (AOR 1.46(1.37-1.56)) risks for ICU/MCU admission. Males had higher adjusted mortality and ICU/MCU admission for all triage categories, and with almost all presenting complaints except for headache.
    Conclusions: Although patient characteristics at ED presentation for both sexes are comparable, males are at higher unadjusted and adjusted risk for adverse outcomes. Males have higher risks in all triage categories and with almost all presenting complaints. Future studies should investigate reasons for higher risk in male ED patients.
    MeSH term(s) Cohort Studies ; Emergency Service, Hospital ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Retrospective Studies ; Risk Assessment ; Sex Characteristics ; Triage
    Language English
    Publishing date 2021-09-12
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The association between vital signs and clinical outcomes in emergency department patients of different age categories.

    Candel, Bart Gj / Duijzer, Renée / Gaakeer, Menno I / Ter Avest, Ewoud / Sir, Özcan / Lameijer, Heleen / Hessels, Roger / Reijnen, Resi / van Zwet, Erik W / de Jonge, Evert / de Groot, Bas

    Emergency medicine journal : EMJ

    2022  Volume 39, Issue 12, Page(s) 903–911

    Abstract: Background: Appropriate interpretation of vital signs is essential for risk stratification in the emergency department (ED) but may change with advancing age. In several guidelines, risk scores such as the Systemic Inflammatory Response Syndrome : ... ...

    Abstract Background: Appropriate interpretation of vital signs is essential for risk stratification in the emergency department (ED) but may change with advancing age. In several guidelines, risk scores such as the Systemic Inflammatory Response Syndrome
    Aims: To assess the association between initial vital signs and case-mix adjusted in-hospital mortality in different age categories.
    Methods: Observational multicentre cohort study using the Netherlands Emergency Department Evaluation Database (NEED) in which consecutive ED patients ≥18 years were included between 1 January 2017 and 12 January 2020. The association between vital signs and case-mix adjusted mortality were assessed in three age categories (18-65; 66-80; >80 years) using multivariable logistic regression. Vital signs were each divided into five to six categories, for example, systolic blood pressure (SBP) categories (≤80, 81-100, 101-120, 121-140, >140 mm Hg).
    Results: We included 101 416 patients of whom 2374 (2.3%) died. Adjusted ORs for mortality increased gradually with decreasing SBP and decreasing peripheral oxygen saturation (SpO
    Conclusion: For SBP, DBP, SpO
    MeSH term(s) Humans ; Aged ; Emergency Service, Hospital ; Cohort Studies ; Vital Signs ; Hospital Mortality ; Systemic Inflammatory Response Syndrome/diagnosis ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2020-210628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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