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  1. Artikel ; Online: Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants

    Peace C. Asuzu / Nicholas S. Trompeter / Carlton R. Cooper / Samuel A. Besong / Alberta N. A. Aryee

    Molecules, Vol 27, Iss 1087, p

    2022  Band 1087

    Abstract: Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their ... ...

    Abstract Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.
    Schlagwörter medicinal plants ; antioxidant activity ; cell lines ; cytotoxicity ; apoptosis ; bioprinting ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Role of αvβ3 in Prostate Cancer Progression

    Carlton R. Cooper / Christopher H. Chay / Kenneth J. Pienta

    Neoplasia : An International Journal for Oncology Research, Vol 4, Iss 3, Pp 191-

    2002  Band 194

    Abstract: Integrin αvβ3 is involved in varied cell biological activities, including angiogenesis, cell adhesion, and migration on several extracellular matrix components. Although αvβ3 is not typically expressed in epithelial cells, it is expressed in macrophages, ...

    Abstract Integrin αvβ3 is involved in varied cell biological activities, including angiogenesis, cell adhesion, and migration on several extracellular matrix components. Although αvβ3 is not typically expressed in epithelial cells, it is expressed in macrophages, activated leukocytes, cytokine-stimulated endothelial cells, osteoclasts, and certain invasive tumors. Interestingly, the adhesion and migration of breast cancer cells on bone matrix are mediated, in part, by αvβ3. Similar to breast cancer cells, prostate cancer cells preferentially metastasize to the bone. The biological events that mediate this metastatic pattern of prostate cancer are not well defined. This review discusses the role αvβ3 plays in prostate cancer progression, with specific emphasis on bone metastasis and on αvβ3 signaling in prostate cancer cells. The data suggest that αvβ3, in part, facilitates prostate cancer metastasis to bone by mediating prostate cancer cell adhesion to and migration on osteopontin and vitronectin, which are common proteins in the bone microenvironment. These biological events require the activation of focal adhesion kinase and the subsequent activation of PI-3 kinase/Akt signaling pathway.
    Schlagwörter bone metastasis ; human prostate cancer cells ; αvβ3 ; extracellular matrix ; PI-3/Akt pathway ; Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Erscheinungsdatum 2002-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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