Artikel: Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery.
Handbook of experimental pharmacology
2024 Band 284, Seite(n) 313–328
Abstract: Respiratory diseases are a major concern in public health, impacting a large population worldwide. Despite the availability of therapies that alleviate symptoms, selectively addressing the critical points of pathopathways remains a major challenge. ... ...
Abstract | Respiratory diseases are a major concern in public health, impacting a large population worldwide. Despite the availability of therapies that alleviate symptoms, selectively addressing the critical points of pathopathways remains a major challenge. Innovative formulations designed for reaching these targets within the airways, enhanced selectivity, and prolonged therapeutic effects offer promising solutions. To provide insights into the specific medical requirements of chronic respiratory diseases, the initial focus of this chapter is directed on lung physiology, emphasizing the significance of lung barriers. Current treatments involving small molecules and the potential of gene therapy are also discussed. Additionally, we will explore targeting approaches, with a particular emphasis on nanoparticles, comparing targeted and non-targeted formulations for pulmonary administration. Finally, the potential of inhaled sphingolipids in the context of respiratory diseases is briefly discussed, highlighting their promising prospects in the field. |
---|---|
Mesh-Begriff(e) | Humans ; Drug Delivery Systems ; Lung Diseases/drug therapy ; Lung ; Administration, Inhalation ; Respiratory Tract Diseases |
Sprache | Englisch |
Erscheinungsdatum | 2024-01-03 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ISSN | 0171-2004 |
ISSN | 0171-2004 |
DOI | 10.1007/164_2023_703 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Sign. bis Bd. 125 (1997): 1982 A 2146: Hefte anzeigen | ||||
danach: Sign. bei den Einzelbänden: Hefte anzeigen |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.