Artikel: Progenitor with cardiometabolic disorders increases food intake, systemic inflammation and gut microbiota alterations in the second-generation offspring
Food & function. 2022 Aug. 15, v. 13, no. 16
2022
Abstract: This work presents the effects of the high-fat diet (H) consumed by the progenitor (G₀) on cardiometabolic disorders and intestinal microbiota in the second-generation offspring (F₂). The rats submitted to H (G₀H) or control (C) (G₀C) diets, during ... ...
Abstract | This work presents the effects of the high-fat diet (H) consumed by the progenitor (G₀) on cardiometabolic disorders and intestinal microbiota in the second-generation offspring (F₂). The rats submitted to H (G₀H) or control (C) (G₀C) diets, during mating, gestation and lactation, generated F₂ offspring (F₂-G₀H and F₂-G₀C, respectively), which received only the C diet. Both, G₀H and F₂-G₀H, showed changes in the intestinal microbiota, increased MAP, plasma TAG levels, adiposity index and the inflammatory process in retroperitoneal fat and in the colon shown by increased TNF-α, MCP-1, MyD88 and CAV-1 gene expression. In addition, F₂-G₀H showed increased food intake, leptin resistance, total cholesterol and plasma levels of MCP-1 and reduced adiponectin. Regarding microbial communities, a greater diversity was observed in 5 unique families of bacteria that was correlated with cardiometabolic disorders. Overall, progenitors with cardiometabolic disorders induce an increase in food intake, systemic inflammation and microbiota alterations in the F₂-G₀H offspring. |
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Schlagwörter | adiponectin ; adiposity ; cholesterol ; colon ; food intake ; gene expression ; high fat diet ; inflammation ; intestinal microorganisms ; lactation ; leptin ; pregnancy ; progeny |
Sprache | Englisch |
Erscheinungsverlauf | 2022-0815 |
Umfang | p. 8685-8702. |
Erscheinungsort | The Royal Society of Chemistry |
Dokumenttyp | Artikel |
ZDB-ID | 2612033-1 |
ISSN | 2042-650X ; 2042-6496 |
ISSN (online) | 2042-650X |
ISSN | 2042-6496 |
DOI | 10.1039/d1fo02838c |
Datenquelle | NAL Katalog (AGRICOLA) |
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