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  1. Buch: Hepatitis delta virus

    Casey, John L.

    (Current topics in microbiology and immunology ; 307)

    2006  

    Verfasserangabe J. L. Casey (ed.)
    Serientitel Current topics in microbiology and immunology ; 307
    Überordnung
    Schlagwörter Hepatitis-D-Virus ; Delta-Hepatitis
    Schlagwörter Hepatitis D ; Hepatitis-Delta-Virus ; HDV ; Hepatitisvirus D
    Sprache Englisch
    Umfang VII, 228 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Berlin u.a.
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT014737037
    ISBN 978-3-540-29801-4 ; 3-540-29801-0
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    Ud II Zs 24 -307- verfügbar in Königswinter Königswinter

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  2. Artikel: Management Protocol for Uncomplicated Peritonsillar Abscess: Standardizing Care and Improving Emergency Medicine Resident Confidence.

    Casey, John / Keidel, Scott / Kudo, Marissa / Chan, Miriam

    Cureus

    2024  Band 16, Heft 1, Seite(n) e53223

    Abstract: Introduction: A peritonsillar abscess (PTA) is a frequent reason for a visit to the emergency department. As there are no current published guidelines for medical versus surgical management, attending physicians vary among management tendencies, ... ...

    Abstract Introduction: A peritonsillar abscess (PTA) is a frequent reason for a visit to the emergency department. As there are no current published guidelines for medical versus surgical management, attending physicians vary among management tendencies, generating uncertainty among resident physicians. This project established a standard of care for managing patients with PTA and provided clear management guidelines to the emergency department, in collaboration with the otolaryngology department, at a community academic hospital.
    Methods: Pre- and post-interventional, anonymous surveys were given to assess resident physician confidence in the management of PTA. A proposed management protocol was developed based on existing literature and approved by both the emergency medicine (EM) and otolaryngology (ENT) departments. The protocol was then disseminated during in-person didactic sessions to EM residents and ENT residents for use over a four-month interventional period.
    Results: The mean confidence level for all residents increased significantly after the implementation of the protocol (p<0.001). The increase in confidence level for "antibiotic selection for PTA" (p=0.72) and "inpatient PTA management" (p=0.20) was not statistically significant for the post-graduate year (PGY) 3 and 4 residents. The increase in confidence level was higher overall for PGY 1 and 2 residents (95% CI 2.25 ± 1.09, p<0.001) than for PGY 3 and 4 residents (95% CI 1.73 ± 1.09, p=0.003).
    Conclusion: The implementation of a standardized protocol for the management of PTA proved to be an effective tool in assisting residents and improving their confidence. This study highlights the importance of establishing guidelines in clinical practice to promote consistent and evidence-based management strategies for PTA. By providing clear guidelines, this protocol enhances communication among healthcare providers and contributes to the delivery of high-quality care to patients with PTA.
    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53223
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Acute Generalized Exanthematous Pustulosis: A Painful and Pruritic Presentation of Pustulosis Following Pharmacotherapy for Pharyngeal Phlegmon.

    Silvers, Chase / Casey, John

    Cureus

    2022  Band 14, Heft 4, Seite(n) e24072

    Abstract: Acute generalized exanthematous pustulosis (AGEP) is primarily a drug-induced skin eruption, which typically presents within two days of starting an offending medication; it is often self-limiting with spontaneous resolution within two weeks upon ... ...

    Abstract Acute generalized exanthematous pustulosis (AGEP) is primarily a drug-induced skin eruption, which typically presents within two days of starting an offending medication; it is often self-limiting with spontaneous resolution within two weeks upon medication cessation. We report the case of a patient who presented with generalized desquamation, characteristic pustules, and several morbilliform rashes on the body surface in association with recent amoxicillin-clavulanic acid exposure. This was associated with significant pruritus, which was the associated chief complaint. A multimodal approach to symptomatic management with topical corticosteroids, barrier ointments, oral antihistamines, and analgesics was required, in addition to the cessation of the offending medication.
    Sprache Englisch
    Erscheinungsdatum 2022-04-12
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24072
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Bothsiderism.

    Aikin, Scott F / Casey, John P

    Argumentation

    2022  Band 36, Heft 2, Seite(n) 249–268

    Abstract: This paper offers an account of a fallacy we will ... ...

    Abstract This paper offers an account of a fallacy we will call
    Sprache Englisch
    Erscheinungsdatum 2022-01-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1481509-6
    ISSN 1572-8374 ; 0920-427X
    ISSN (online) 1572-8374
    ISSN 0920-427X
    DOI 10.1007/s10503-021-09563-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  5. Artikel ; Online: Quality improvement review of O positive blood in emergency transfusion.

    Chowdhury, Rakin / Williams, Bronwyn A / Williams, Sue / Casey, John

    Transfusion

    2023  Band 63, Heft 10, Seite(n) 1841–1848

    Abstract: Background: We recently introduced a policy to use O positive red cells in emergency transfusions for males >16 years of age and females >50 years of age. Here, we investigate changes in emergency transfusion practice and rates of red cell ... ...

    Abstract Background: We recently introduced a policy to use O positive red cells in emergency transfusions for males >16 years of age and females >50 years of age. Here, we investigate changes in emergency transfusion practice and rates of red cell alloimmunization with the use of O positive blood for emergency transfusion.
    Study design and methods: State-wide retrospective review of emergency transfusions between June 2020 and June 2021. The laboratory information system and patient medical records were used to collect demographic details, indications for transfusion, usage of O positive and O negative blood and rates of alloimmunization.
    Results: There were 2354 red cell units transfused to 1013 patients (male = 59%, average age = 53 years) during the 12-month period. O positive units accounted for 46.9% (1103 units) of emergency transfusions. However, 726 (30.8%) O negative units were transfused to patients without a mandatory indication for O negative blood. Twenty-eight patients (2.9%) had a red cell alloantibody prior to transfusion including anti-E (n = 10), anti-D (n = 4), and anti-K (n = 4). One patient with prior anti-D had mild delayed hemolysis. There were 19 patients (4.3%, median follow-up 22 days) who developed a red cell alloantibody after emergency transfusion and include anti-E (n = 10), anti-D (n = 7), and anti-C (n = 5).
    Discussion: The use of O positive blood for emergency transfusion has saved 1103 O negative red cell units with no detriment to patient outcome. There remains potential to optimize use of O positive blood in emergency transfusion and to understand red cell alloimmunization rates in a prospective fashion.
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17537
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  6. Artikel: A Case of Phlegmasia Cerulea Dolens.

    Barnett, Davin / Casey, John

    Cureus

    2020  Band 12, Heft 9, Seite(n) e10187

    Abstract: Phlegmasia cerulea dolens (PCD) is a rare presenting condition that carries a high mortality and morbidity risk. It is a cannot miss diagnosis with potentially deadly sequelae, and we highlight the importance of a thorough physical examination and ... ...

    Abstract Phlegmasia cerulea dolens (PCD) is a rare presenting condition that carries a high mortality and morbidity risk. It is a cannot miss diagnosis with potentially deadly sequelae, and we highlight the importance of a thorough physical examination and initiation of empiric treatment to help prevent such.
    Sprache Englisch
    Erscheinungsdatum 2020-09-01
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.10187
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A steady-state model of microbial acclimation to substrate limitation.

    Casey, John R / Follows, Michael J

    PLoS computational biology

    2020  Band 16, Heft 8, Seite(n) e1008140

    Abstract: Microbes acclimate to changes in substrate availability by altering the number of transporters on the cell surface, however there is some disagreement on just how. We revisit the physics of substrate uptake and consider the steady-state scenario whereby ... ...

    Abstract Microbes acclimate to changes in substrate availability by altering the number of transporters on the cell surface, however there is some disagreement on just how. We revisit the physics of substrate uptake and consider the steady-state scenario whereby cells have acclimated to maximize fitness. Flux balance analysis of a stoichiometric model of Escherichia coli was used in conjunction with quantitative proteomics data and molecular modeling of membrane transporters to reconcile these opposing views. An emergent feature of the proposed model is a critical substrate concentration S*, which delineates two rate limits. At concentrations above S*, transporter abundance can be regulated to maintain uptake rates as demanded by maximal growth rates, whereas below S*, uptake rates are strictly diffusion limited. In certain scenarios, the proposed model can take on a qualitatively different shape from the familiar hyperbolic kinetics curves, instead resembling the long-forgotten Blackman kinetics.
    Mesh-Begriff(e) Acclimatization ; Algorithms ; Escherichia coli/metabolism ; Models, Biological ; Proteomics ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2020-08-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1008140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch: The nonprofit world

    Casey, John

    civil society and the rise of the nonprofit sector

    2016  

    Abstract: John Casey explores the expanding global reach of nonprofit organizations, examining the increasingly influential role not only of prominent NGOs that work on hot-button global issues, but also of the thousands of smaller, little-known organizations that ...

    Verfasserangabe John Casey
    Abstract John Casey explores the expanding global reach of nonprofit organizations, examining the increasingly influential role not only of prominent NGOs that work on hot-button global issues, but also of the thousands of smaller, little-known organizations that have an impact on people's daily lives.

    The nonprofit world -- The rise of the nonprofit sector -- The evolution of the nonprofit sector -- Comparing national nonprofit sectors -- The globalization of ideas -- The internationalization of the nonprofit sector -- International nonprofits at work -- Stewarding international nonprofits -- Emerging trends
    Schlagwörter Nonprofit organizations ; Nonprofit-Organisation ; Welt
    Sprache Nicht zu entscheiden
    Umfang xii, 356 Seiten, Illustrationen, 23 cm
    Verlag Kumarian Press, a division of Lynne Rienner Publishers, Inc
    Erscheinungsort Boulder ; London
    Dokumenttyp Buch
    Anmerkung Literaturverzeichnis: Seiten 303-328
    ISBN 1565495292 ; 1565495306 ; 9781565495296 ; 9781565495302
    Datenquelle ECONomics Information System

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  9. Artikel ; Online: Hepatitis Delta Virus Genome RNA Synthesis Initiates at Position 1646 with a Nontemplated Guanosine.

    Stephenson-Tsoris, Susannah / Casey, John L

    Journal of virology

    2021  Band 96, Heft 4, Seite(n) e0201721

    Abstract: Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three RNAs in infected cells, genome, ... ...

    Abstract Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three RNAs in infected cells, genome, antigenome, and mRNA; the latter encodes hepatitis delta antigen (HDAg), the viral protein. These RNAs are synthesized by host DNA-dependent RNA polymerase acting as an RNA-dependent RNA polymerase. Although HDV genome RNA accumulates to high levels in infected cells, the mechanism by which this process occurs remains poorly understood. For example, the nature of the 5' end of the genome, including the synthesis start site and its chemical composition, is not known. Analysis of this process has been challenging because the initiation site is part of an unstable precursor in the rolling-circle mechanism by which HDV genome RNA is synthesized. In this study, circular HDV antigenome RNAs synthesized
    Mesh-Begriff(e) Cell Line ; Genome, Viral ; Guanosine ; Hepatitis Delta Virus/genetics ; Hepatitis Delta Virus/physiology ; Humans ; RNA Caps ; RNA Polymerase II/metabolism ; RNA, Circular/biosynthesis ; RNA, Circular/chemistry ; RNA, Viral/biosynthesis ; RNA, Viral/chemistry ; Templates, Genetic ; Transfection ; Virus Replication
    Chemische Substanzen RNA Caps ; RNA, Circular ; RNA, Viral ; Guanosine (12133JR80S) ; RNA Polymerase II (EC 2.7.7.-)
    Sprache Englisch
    Erscheinungsdatum 2021-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.02017-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions.

    Martin, David / Alberti, Piero / Demartines, Nicolas / Phillips, Melanie / Casey, John / Sutherland, Andrew

    Journal of clinical medicine

    2023  Band 12, Heft 9

    Abstract: Whole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on ... ...

    Abstract Whole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on several factors such as kidney function, patient comorbidities, and treatment goals. For a patient with end-stage kidney disease, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK). However, it remains a major surgical procedure in patients with multiple comorbidities and therefore it is important to select those who will benefit from it. Additionally, in view of the organ shortage, new strategies to improve outcomes and reduce immune reactions have been developed, including dynamic organ perfusion technologies, pancreas bioengineering, and stem cell therapies. The purpose of this article is to review the indications, surgical techniques, outcomes, and future directions of whole-organ pancreas and islets transplantations.
    Sprache Englisch
    Erscheinungsdatum 2023-05-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093245
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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