Article: The genetics of type I interferon in systemic lupus erythematosus
Current Opinion in Immunology. 2012 Oct., v. 24, no. 5
2012
Abstract: The discovery that type I interferon (IFN)-inducible genes were strongly upregulated in peripheral blood in SLE over a decade ago sparked interest in understanding the relationship between type I IFN and SLE. Genome-wide association studies provide ... ...
Abstract | The discovery that type I interferon (IFN)-inducible genes were strongly upregulated in peripheral blood in SLE over a decade ago sparked interest in understanding the relationship between type I IFN and SLE. Genome-wide association studies provide strong genetic evidence that type I IFNs are important for SLE risk. Of 47 genetic variants associated with SLE, over half (27/47, 57%) can be linked to type I IFN production or signaling. The recent identification of single gene mutations for disorders that share features with SLE – Aicardi–Goutières syndrome, chilblain lupus, and spondyloenchondrodysplasia – provide additional support for the hypothesis that type I IFNs are central drivers of SLE pathogenesis. These insights provide significant focus for efforts to tackle SLE therapeutically. |
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Keywords | blood ; gene expression regulation ; genes ; genetic variation ; genome-wide association study ; interferons ; lupus erythematosus ; mutation ; pathogenesis ; risk |
Language | English |
Dates of publication | 2012-10 |
Size | p. 530-537. |
Publishing place | Elsevier Ltd |
Document type | Article |
ZDB-ID | 1035767-1 |
ISSN | 1879-0372 ; 0952-7915 |
ISSN (online) | 1879-0372 |
ISSN | 0952-7915 |
DOI | 10.1016/j.coi.2012.07.008 |
Database | NAL-Catalogue (AGRICOLA) |
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