LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel: Chemical Constituents of

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants (Basel, Switzerland)

    2022  Band 11, Heft 2

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran ( ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (
    Sprache Englisch
    Erscheinungsdatum 2022-02-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: Chemical Constituents of Hedyotis diffusa and Their Anti-Inflammatory Bioactivities

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants. 2022 Feb. 09, v. 11, no. 2

    2022  

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and ... ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among these isolates, selected compounds were examined for their anti-inflammatory activity. The results showed that rare substituted anthraquinones displayed potent inhibitory activity with IC₅₀ values ranging from 0.15 ± 0.01 to 5.52 ± 1.59 µM on the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release cellular models. Meanwhile, the proposed drug target of the active anthraquinone was studied by computer modeling. The binding affinity between the anti-inflammatory anthraquinone and elastase was evaluated by molecular docking. These results provided the scientific insight into the medicinal values of Hedyotis diffusa and vision of development as lead compounds.
    Schlagwörter Oldenlandia diffusa ; anthraquinones ; anti-inflammatory activity ; computers ; drugs ; elastase ; spectroscopy ; superoxide anion ; vision
    Sprache Englisch
    Erscheinungsverlauf 2022-0209
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang