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  1. Buch ; Online ; E-Book: COVID-19

    Qu, Jie-Ming / Cao, Bin / Chen, Rong-Chang

    the essentials of prevention and treatment

    2021  

    Verfasserangabe Jie-Ming Qu, Bin Cao, Rong-Chang Chen
    Schlagwörter COVID-19 (Disease)/Treatment ; COVID-19 (Disease)/Prevention
    Thema/Rubrik (Code) 616.2414
    Sprache Englisch
    Umfang 1 Online-Ressource (x, 103 Seiten), Illustrationen, Diagramme
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Erscheinungsland Niederlande
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020626889
    ISBN 978-0-12-824251-3 ; 9780128240038 ; 0-12-824251-5 ; 0128240032
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Triple therapy in chronic obstructive pulmonary disease: consideration under new evidence.

    Gao, Yong-Hua / Chen, Rong-Chang

    Chinese medical journal

    2021  Band 134, Heft 13, Seite(n) 1513

    Mesh-Begriff(e) Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents/therapeutic use ; Drug Therapy, Combination ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemische Substanzen Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents
    Sprache Englisch
    Erscheinungsdatum 2021-02-15
    Erscheinungsland China
    Dokumenttyp Editorial
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001340
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Strategies for the prevention and management of coronavirus disease 2019.

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    The European respiratory journal

    2020  Band 55, Heft 4

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-16
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00597-2020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Effect of continuing the use of renin-angiotensin system inhibitors on mortality in patients hospitalized for coronavirus disease 2019: a systematic review, meta-analysis, and meta-regression analysis.

    Liu, Qi / Fu, Wei / Zhu, Chang-Ju / Ding, Zi-Heng / Dong, Bin-Bin / Sun, Bao-Qing / Chen, Rong-Chang

    BMC infectious diseases

    2023  Band 23, Heft 1, Seite(n) 53

    Abstract: Background: The effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on mortality was preliminarily explored through the comparison of ACEIs/ARBs with non-ACEIs/ARBs in patients with coronavirus disease 2019 ( ... ...

    Abstract Background: The effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on mortality was preliminarily explored through the comparison of ACEIs/ARBs with non-ACEIs/ARBs in patients with coronavirus disease 2019 (COVID-19). Reaching a conclusion on whether previous ACEI/ARB treatment should be continued in view of the different ACE2 levels in the comparison groups was not unimpeachable. Therefore, this study aimed to further elucidate the effect of ACEI/ARB continuation on hospital mortality, intensive care unit (ICU) admission, and invasive mechanical ventilation (IMV) in the same patient population.
    Methods: We searched PubMed, the Cochrane Library, Ovid, and Embase for relevant articles published between December 1, 2019 and April 30, 2022. Continuation of ACEI/ARB use after hospitalization due to COVID-19 was considered as an exposure and discontinuation of ACEI/ARB considered as a control. The primary outcome was hospital mortality, and the secondary outcomes included 30-day mortality, rate of ICU admission, IMV, and other clinical outcomes.
    Results: Seven observational studies and four randomized controlled trials involving 2823 patients were included. The pooled hospital mortality in the continuation group (13.04%, 158/1212) was significantly lower than that (22.15%, 278/1255) in the discontinuation group (risk ratio [RR] = 0.45; 95% confidence interval [CI], 0.28-0.72; P = 0.001). Continuation of ACEI/ARB use was associated with lower rates of ICU admission (10.5% versus 16.2%, RR = 0.63; 95% CI 0.5-0.79; P < 0.0001) and IMV (8.2% versus 12.5%, RR = 0.62; 95% CI 0.46-0.83, P = 0.001). Nevertheless, the effect was mainly demonstrated in the observational study subgroup (P < 0.05). Continuing ACEI/ARB had no significant effect on 30-day mortality (P = 0.34), acute myocardial infarction (P = 0.08), heart failure (P = 0.82), and acute kidney injury after hospitalization (P = 0.98).
    Conclusion: Previous ACEI/ARB treatment could be continued since it was associated with lower hospital deaths, ICU admission, and IMV in patients with COVID-19, although the benefits of continuing use were mainly shown in observational studies. More evidence from multicenter RCTs are still needed to increase the robustness of the data. Trial registration PROSPERO (CRD42022341169). Registered 27 June 2022.
    Mesh-Begriff(e) Humans ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; COVID-19 ; Angiotensin Receptor Antagonists/therapeutic use ; Renin-Angiotensin System ; Antihypertensive Agents/therapeutic use ; Regression Analysis ; Randomized Controlled Trials as Topic ; Observational Studies as Topic ; Multicenter Studies as Topic
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Antihypertensive Agents
    Sprache Englisch
    Erscheinungsdatum 2023-01-24
    Erscheinungsland England
    Dokumenttyp Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-07994-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Strategies for the prevention and management of coronavirus disease 2019

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    European respiratory journal, Early view

    2020  

    Abstract: Early protection, early identification, early diagnosis, and early isolation are crucial to combat with Covid-19 outbreaks. Since the outbreak in Wuhan city in December 2019, there has been a surge of newly diagnosed cases with coronavirus disease 2019 ( ... ...

    Abstract Early protection, early identification, early diagnosis, and early isolation are crucial to combat with Covid-19 outbreaks. Since the outbreak in Wuhan city in December 2019, there has been a surge of newly diagnosed cases with coronavirus disease 2019 (Covid-19) globally [1–4]. The total number has reached to 101 927 laboratory-confirmed cases as of March 8th, 2020 [5]. An increasing number of countries have issued the alert of the highest level.
    Schlagwörter COVID-19 ; control ; Transmission ; laboratory testing ; prevention ; therapy ; covid19
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation

    Xu, Li-jiao / Chen, Rong-chang / Ma, Xiao-yu / Zhu, Yue / Sun, Gui-bo / Sun, Xiao-bo

    Phytomedicine. 2020 Mar., v. 68

    2020  

    Abstract: Activation of NLRP3 inflammasome plays a key role in cardiac dysfunction for acute myocardial ischemia-reperfusion injury. Scutellarin (Scu) is a flavonoid purified from Erigeron breviscapus. Whether Scu has any influence on the activation of NLRP3 ... ...

    Abstract Activation of NLRP3 inflammasome plays a key role in cardiac dysfunction for acute myocardial ischemia-reperfusion injury. Scutellarin (Scu) is a flavonoid purified from Erigeron breviscapus. Whether Scu has any influence on the activation of NLRP3 inflammasome in cardiomyocytes remains unknown.We aimed to examine the therapeutic effect of Scu on cardiomyocyte ischemia-reperfusion (I/R) injury and its effect on NLRP3 inflammasome in rats with acute myocardial I/R injury and anoxia/reoxygenation (A/R)-induced H9c2 injuries.Heart injuries were induced through 30 min of ischemia followed by 24 h of reperfusion. Scu was intraperitoneally administered 15 min before vascular ligation. Effects of Scu on cardiac injury were detected by echocardiograms, TTC staining, and histological and immunohistochemical analyses. The effects of Scu on biochemical parameters were analyzed. H9c2 cells were pretreated with different concentrations of Scu for 6 h before A/R exposure. Afterward, cell viability, LDH release, and Hoechst 33342 and peromide iodine double staining were determined. Western blot analyses of proteins, including those involved in autophagy, NLRP3, mTOR complex 1 (mTORC1), and Akt signaling, were conducted.In vivo study revealed that Scu improved diastolic dysfunction, ameliorated myocardium structure abnormality, inhibited myocyte apoptosis and inflammatory response, and promoted autophagy. Scu reduced NLRP3 inflammasome activation, inhibited mTORC1 activity, and increased Akt phosphorylation. In vitro investigation showed the same results. The Scu-mediated NLRP3 inflammasome and mTORC1 inhibition and cardioprotection were abolished through the genetic silencing of Akt by siRNA.The cardioprotective effect of Scu was achieved through its anti-inflammatory effect. It suppressed the activation of NLRP3 inflammasome. In addition, inflammasome restriction by Scu was dependent on Akt activation and mTORC1 inhibition.
    Schlagwörter Erigeron breviscapus ; Western blotting ; anti-inflammatory activity ; apoptosis ; autophagy ; cardiomyocytes ; cardioprotective effect ; cell viability ; flavonoids ; hypoxia ; inflammasomes ; inflammation ; iodine ; ischemia ; phosphorylation ; staining ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2020-03
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2020.153169
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Sporadic Dissemination of

    Cheng, Ying-Ying / Liu, Yang / Chen, Yong / Huang, Fu-Man / Chen, Rong-Chang / Xiao, Yong-Hong / Zhou, Kai

    Microbiology spectrum

    2021  Band 9, Heft 3, Seite(n) e0114121

    Abstract: The emergence of high-level tigecycline resistance mediated by plasmid- ... ...

    Abstract The emergence of high-level tigecycline resistance mediated by plasmid-borne
    Mesh-Begriff(e) Acinetobacter/drug effects ; Acinetobacter/genetics ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/veterinary ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Cattle ; Livestock/microbiology ; Microbial Sensitivity Tests ; Mixed Function Oxygenases/genetics ; Plasmids/genetics ; Sheep/microbiology ; Swine/microbiology ; Tetracycline Resistance/genetics ; Tigecycline/pharmacology
    Chemische Substanzen Anti-Bacterial Agents ; Bacterial Proteins ; Tigecycline (70JE2N95KR) ; Mixed Function Oxygenases (EC 1.-)
    Sprache Englisch
    Erscheinungsdatum 2021-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/Spectrum.01141-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The bronchiectasis severity index and FACED score for bronchiectasis.

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    The European respiratory journal

    2016  Band 47, Heft 2, Seite(n) 382–384

    Mesh-Begriff(e) Bronchiectasis ; Forced Expiratory Volume ; Humans ; Severity of Illness Index ; Tomography, X-Ray Computed
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland England
    Dokumenttyp Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01717-2015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: [Lung stress and strain in mechanical ventilation for patients with acute respiratory distress syndrome].

    Liu, Qi / Chen, Rong-chang

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2012  Band 35, Heft 12, Seite(n) 924–926

    Mesh-Begriff(e) Humans ; Lung/physiopathology ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/therapy ; Stress, Mechanical
    Sprache Chinesisch
    Erscheinungsdatum 2012-12
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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