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  1. Artikel ; Online: Acetic acid as a protic solvent for reducing sulphuric acid concentrations in the production of cellulose nanocrystals alongside transition metal co-catalysts.

    Lim, Carine Shu Shien / Chan, Eric Wei Chiang / Wong, Chen Wai

    International journal of biological macromolecules

    2024  Band 259, Heft Pt 2, Seite(n) 129303

    Abstract: Cellulose nanocrystals (CNC) conventionally involve highly concentrated sulphuric acid, which typically resulted in the formation of undesirable by-products. Although less corrosive mineral acids have been explored as alternatives, high concentrations ... ...

    Abstract Cellulose nanocrystals (CNC) conventionally involve highly concentrated sulphuric acid, which typically resulted in the formation of undesirable by-products. Although less corrosive mineral acids have been explored as alternatives, high concentrations are still required. In this study, CNC was successfully isolated from Leucaena leucocephala wood using mild sulphuric acid with acetic acid as protic solvent, and it was further studied with the addition of Lewis acids in the form of multivalent transition metal salts as co-catalyst. Selected divalent and trivalent transition metal salts including (Cr(NO
    Mesh-Begriff(e) Cellulose/chemistry ; Solvents ; Acetic Acid ; Salts ; Nanoparticles/chemistry ; Sulfuric Acids/chemistry
    Chemische Substanzen Cellulose (9004-34-6) ; Solvents ; Acetic Acid (Q40Q9N063P) ; Salts ; sulfuric acid (O40UQP6WCF) ; Sulfuric Acids
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129303
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Effects of stand-alone polar residue on membrane protein stability and structure.

    Chang, Yu-Chu / Cao, Zheng / Chen, Wai-Ting / Huang, Wei-Chun

    Biochimica et biophysica acta. Biomembranes

    2024  Band 1866, Heft 5, Seite(n) 184325

    Abstract: Helical membrane proteins generally have a hydrophobic nature, with apolar side chains comprising the majority of the transmembrane (TM) helices. However, whenever polar side chains are present in the TM domain, they often exert a crucial role in ... ...

    Abstract Helical membrane proteins generally have a hydrophobic nature, with apolar side chains comprising the majority of the transmembrane (TM) helices. However, whenever polar side chains are present in the TM domain, they often exert a crucial role in structural interactions with other polar residues, such as TM helix associations and oligomerization. Moreover, polar residues in the TM region also often participate in protein functions, such as the Schiff base bonding between Lys residues and retinal in rhodopsin-like membrane proteins. Although many studies have focused on these functional polar residues, our understanding of stand-alone polar residues that are energetically unfavored in TM helixes is limited. Here, we adopted bacteriorhodopsin (bR) as a model system and systematically mutated 17 of its apolar Leu or Phe residues to polar Asn. Stability measurements of the resulting mutants revealed that all of these polar substitutions reduced bR stability to various extents, and the extent of destabilization of each mutant bR is also correlated to different structural factors, such as the relative accessible surface area and membrane depth of the mutation site. Structural analyses of these Asn residues revealed that they form sidechain-to-backbone hydrogen bonds that alleviate the unfavorable energetics in hydrophobic and apolar surroundings. Our results indicate that membrane proteins are able to accommodate certain stand-alone polar residues in the TM region without disrupting overall structures.
    Mesh-Begriff(e) Bacteriorhodopsins/chemistry ; Bacteriorhodopsins/genetics ; Bacteriorhodopsins/metabolism ; Protein Stability ; Hydrophobic and Hydrophilic Interactions ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mutation ; Protein Structure, Secondary ; Halobacterium salinarum/chemistry ; Halobacterium salinarum/genetics ; Halobacterium salinarum/metabolism ; Models, Molecular
    Chemische Substanzen Bacteriorhodopsins (53026-44-1) ; Membrane Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-04-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2024.184325
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Differences between DSM-5-TR and ICD-11 revisions of attention deficit/hyperactivity disorder: A commentary on implications and opportunities.

    Gomez, Rapson / Chen, Wai / Houghton, Stephen

    World journal of psychiatry

    2023  Band 13, Heft 5, Seite(n) 138–143

    Abstract: Current ICD-11 descriptions for attention deficit hyperactivity disorder (ADHD) were recently published online, in the same year as the DSM-5-TR (text revised edition) was released. In this commentary, we compare and contrast the DSM-5/DSM-5-TR and ICD- ... ...

    Abstract Current ICD-11 descriptions for attention deficit hyperactivity disorder (ADHD) were recently published online, in the same year as the DSM-5-TR (text revised edition) was released. In this commentary, we compare and contrast the DSM-5/DSM-5-TR and ICD-11 diagnostic criteria, summarize important differences, and underscore their clinical and research implications. Overall, three major differences emerge: (1) The number of diagnostic criteria for inattention (IA), hyperactivity (HY) and impulsivity (IM) symptoms (
    Sprache Englisch
    Erscheinungsdatum 2023-05-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v13.i5.138
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  4. Artikel ; Online: The NDIS at ten years: designing an equitable scheme for the next decade.

    Hill, Nicole Tm / Chen, Wai / Downs, Jenny

    The Medical journal of Australia

    2023  Band 220, Heft 1, Seite(n) 54

    Mesh-Begriff(e) Humans ; Disabled Persons ; Insurance, Disability
    Sprache Englisch
    Erscheinungsdatum 2023-11-27
    Erscheinungsland Australia
    Dokumenttyp Letter
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.52175
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  5. Artikel ; Online: Sertraline-Induced Tics: A Case Report and Narrative Review.

    Arasu, Ramesh / Badeshae, Semran / Furlong, Yulia / Chen, Wai

    Journal of pharmacy practice

    2022  Band 36, Heft 6, Seite(n) 1528–1531

    Abstract: This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; ... ...

    Abstract This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; after this, paroxetine was trialled and well tolerated with good response of targeted symptoms and without re-emergence of tics. A narrative literature review yielded a retrospective observational study and eight single case reports on selective serotonin receptor inhibitor-induced motor tics (three in adolescents and five in adults). Tics are not commonly considered as a side-effect of SSRIs. This case report is novel is several aspects: the tics emergence was immediate whereas previous cases were delayed; the tics symptoms were measured and quantified by a validated scale; a dose-response relationship was observed; to our knowledge, our case was the first adolescent female reported; and finally, paroxetine was well-tolerated as a substitute, although it is unclear whether the observed tics-sparing effect is co-incidental, ideocratic or can be replicated.
    Mesh-Begriff(e) Adolescent ; Female ; Humans ; Anxiety ; Observational Studies as Topic ; Paroxetine/therapeutic use ; Selective Serotonin Reuptake Inhibitors ; Sertraline/adverse effects ; Tics/chemically induced ; Tics/drug therapy ; Adult
    Chemische Substanzen Paroxetine (41VRH5220H) ; Selective Serotonin Reuptake Inhibitors ; Sertraline (QUC7NX6WMB)
    Sprache Englisch
    Erscheinungsdatum 2022-08-09
    Erscheinungsland United States
    Dokumenttyp Review ; Case Reports ; Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900221118015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Inter-relationships between ADHD, ODD and impulsivity dimensions in emerging adults revealed by network analysis: extending the 'trait impulsivity hypothesis'.

    Gomez, Rapson / Stavropoulos, Vasileios / Watson, Shaun / Brown, Taylor / Chen, Wai

    Heliyon

    2022  Band 8, Heft 10, Seite(n) e10712

    Abstract: Background: The trait-impulsivity hypothesis posits impulsivity as the underlying substrate of Attention-deficit/hyperactivity disorder (ADHD) and Oppositional defiant disorder (ODD) symptom expressions. The current study applied network analysis to ... ...

    Abstract Background: The trait-impulsivity hypothesis posits impulsivity as the underlying substrate of Attention-deficit/hyperactivity disorder (ADHD) and Oppositional defiant disorder (ODD) symptom expressions. The current study applied network analysis to evaluate the inter-relationships of dimensions within ADHD (inattention and hyperactivity/impulsivity) and ODD (anger/irritable, vindictiveness, and argumentative/defiant behavior) with components of impulsivity as captured by the UPPS-P model (negative urgency, lack of premeditation, lack of perseverance, sensation seeking, and positive urgency).
    Method: A total of 324 emerging adults (women = 246) from the general community completed questionnaires covering these dimensions.
    Results: Our findings showed that the ADHD and ODD dimensions were associated differentially with different types of impulsivity, in their unique patterns of network connectivities, a possibility that has had little attention in the trait-impulsivity hypothesis literature.
    Conclusions: This study is the first to tease out the unique associations of the ADHD and ODD dimensions with different types of impulsivity, and in that way provide new contributions to our understanding of the existing trait impulsivity theory. Our findings would be especially relevant to those interested in understanding how different dimensions of trait impulsivity underly the ADHD and ODD dimensions.
    Sprache Englisch
    Erscheinungsdatum 2022-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10712
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The trajectory of maternal perinatal depressive symptoms predicts executive function in early childhood.

    Power, Josephine / Watson, Stuart / Chen, Wai / Lewis, Andrew / van IJzendoorn, Marinus / Galbally, Megan

    Psychological medicine

    2023  Band 53, Heft 16, Seite(n) 7953–7963

    Abstract: Background: Perinatal maternal depression may affect fetal neurodevelopment directly or indirectly via exposures such as smoking, alcohol, or antidepressant use. The relative contribution of these risk factors on child executive function (EF) has not ... ...

    Abstract Background: Perinatal maternal depression may affect fetal neurodevelopment directly or indirectly via exposures such as smoking, alcohol, or antidepressant use. The relative contribution of these risk factors on child executive function (EF) has not been explored systematically.
    Methods: A prospective pregnancy cohort of 197 women and their children was studied to determine whether maternal depression diagnosis and the trajectory of maternal depressive symptoms (MDSs) from early pregnancy to 12 months postpartum predicts child EF at age 4 (measured using the preschool age psychiatric assessment, NEPSY-II, and Shape School task) using latent growth curve modeling. Indirect effects of smoking, alcohol, and antidepressant use were also formally tested.
    Results: Increasing maternal perinatal depressive symptoms over time predicted more inattentive symptoms, poorer switching, and motor inhibition, but not cognitive inhibition. When adjusted for multiple comparison, and after accounting for maternal cognition and education, the association with child inattentive symptoms remained significant. However, diagnosed depression did not predict child EF outcomes. Prenatal exposure to smoking, alcohol, and antidepressants also did not mediate pathways from depressive symptoms to EF outcomes. Our findings were limited by sample size and statistical power to detect outcome effects of smaller effect size.
    Conclusions: This study suggests that increasing MDSs over the perinatal period is associated with poorer EF outcomes in children at age 4 - independent of prenatal smoking, drinking, or antidepressant use. Depressive chronicity, severity, and postpartum influences may play crucial roles in determining childhood outcomes of EF.
    Mesh-Begriff(e) Child ; Pregnancy ; Child, Preschool ; Humans ; Female ; Depression ; Executive Function/physiology ; Prospective Studies ; Smoking ; Mothers/psychology ; Antidepressive Agents ; Depression, Postpartum/epidemiology ; Depression, Postpartum/psychology
    Chemische Substanzen Antidepressive Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291723002118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Biodegradable ultrafiltration membrane enhanced with anti-biofouling agent from

    Anggraeni, Vania Septa / Lee, Hoong Chern / Goh, Pei Sean / Sutrisna, Putu Doddy / Chan, Eric Wei Chiang / Wong, Chen Wai

    Biofouling

    2024  , Seite(n) 1–18

    Abstract: Our research focuses on developing environmentally friendly biodegradable ultrafiltration (UF) membranes for small-scale water purification in areas lacking infrastructure or during emergencies. To address biofouling challenges without resorting to ... ...

    Abstract Our research focuses on developing environmentally friendly biodegradable ultrafiltration (UF) membranes for small-scale water purification in areas lacking infrastructure or during emergencies. To address biofouling challenges without resorting to harmful chemicals, we incorporate bio-based extracts, such as methyl gallate from
    Sprache Englisch
    Erscheinungsdatum 2024-06-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2024.2357309
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  9. Artikel: Antioxidant and sensory evaluation of cocoa (Theobroma cacao L.) tea formulated with cocoa bean hull of different origins

    Siow, Cai San / Chan, Eric Wei Chiang / Wong, Chen Wai / Ng, Chee Wai

    Future foods. 2022 June, v. 5

    2022  

    Abstract: Cocoa nibs are the main ingredient for chocolate production while cocoa bean hulls are the major by-product. Uniqueness of this study is that we investigate the antioxidant content and activity of single origin cocoa bean hulls compared to nibs based on ... ...

    Abstract Cocoa nibs are the main ingredient for chocolate production while cocoa bean hulls are the major by-product. Uniqueness of this study is that we investigate the antioxidant content and activity of single origin cocoa bean hulls compared to nibs based on their total phenolic content (TPC), total flavonoid content (TFC), free radical scavenging activity (DPPH Assay), ferric reducing powder (FRAP), and ferrous ion chelating (FIC) ability, thus highlighting regional differences. Venezuela raw cocoa bean hull had the highest antioxidant properties and these properties can tolerate roasting up to 100 ⁰C. Roasting temperature influences both the antioxidant properties and the flavor profile of the resulting cocoa tea. Of the 105 respondents of the hedonic survey, 67.64% indicated that they would buy our cocoa tea. Cocoa tea made from Malaysia and Venezuela origin had a higher theobromine content and a much lower caffeine content compared to green tea. In all cases, cocoa tea made primarily from the cocoa bean hull is safe for consumption as the Aflatoxin (B1, B2, G1, G2), Ochratoxin A, and pesticides residues were not detected within the detection limits (0.001 mg/kg and 0.005 mg/kg). It can be concluded that regional differences give a unique flavor profile to the cocoa bean hull and there were differences in terms of antioxidant properties.
    Schlagwörter Theobroma cacao ; byproducts ; caffeine ; chocolate ; cocoa beans ; flavonoids ; flavor ; free radicals ; green tea ; ingredients ; ochratoxin A ; sensory evaluation ; surveys ; temperature ; theobromine ; Malaysia ; Venezuela
    Sprache Englisch
    Erscheinungsverlauf 2022-06
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 2666-8335
    DOI 10.1016/j.fufo.2021.100108
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Inter-relationships between ADHD, ODD and impulsivity dimensions in emerging adults revealed by network analysis: extending the 'trait impulsivity hypothesis'

    Gomez, Rapson / Stavropoulos, Vasileios / Watson, S. A. / Brown, Taylor / Chen, Wai

    Heliyon. 2022 Oct., v. 8, no. 10 p.e10712-

    2022  

    Abstract: The trait-impulsivity hypothesis posits impulsivity as the underlying substrate of Attention-deficit/hyperactivity disorder (ADHD) and Oppositional defiant disorder (ODD) symptom expressions. The current study applied network analysis to evaluate the ... ...

    Abstract The trait-impulsivity hypothesis posits impulsivity as the underlying substrate of Attention-deficit/hyperactivity disorder (ADHD) and Oppositional defiant disorder (ODD) symptom expressions. The current study applied network analysis to evaluate the inter-relationships of dimensions within ADHD (inattention and hyperactivity/impulsivity) and ODD (anger/irritable, vindictiveness, and argumentative/defiant behavior) with components of impulsivity as captured by the UPPS-P model (negative urgency, lack of premeditation, lack of perseverance, sensation seeking, and positive urgency). A total of 324 emerging adults (women = 246) from the general community completed questionnaires covering these dimensions. Our findings showed that the ADHD and ODD dimensions were associated differentially with different types of impulsivity, in their unique patterns of network connectivities, a possibility that has had little attention in the trait-impulsivity hypothesis literature. This study is the first to tease out the unique associations of the ADHD and ODD dimensions with different types of impulsivity, and in that way provide new contributions to our understanding of the existing trait impulsivity theory. Our findings would be especially relevant to those interested in understanding how different dimensions of trait impulsivity underly the ADHD and ODD dimensions.
    Schlagwörter adults ; models ; personality disorders ; questionnaires ; women ; Trait-impulsivity etiological model ; Attention-deficit/hyperactivity disorder ; Oppositional defiant disorder ; UPPS-P model of impulsive personality ; Emerging adults
    Sprache Englisch
    Erscheinungsverlauf 2022-10
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10712
    Datenquelle NAL Katalog (AGRICOLA)

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