Article ; Online: Squalene Emulsions for Parenteral Vaccine and Drug Delivery
Molecules, Vol 14, Iss 9, Pp 3286-
2009 Volume 3312
Abstract: Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and ... ...
Abstract | Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytica techniques for characterization of squalene emulsions are examined. |
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Keywords | squalene ; squalane ; adjuvant ; emulsion ; parenteral ; Organic chemistry ; QD241-441 |
Language | English |
Publishing date | 2009-09-01T00:00:00Z |
Publisher | MDPI AG |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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