Artikel ; Online: ATRX/DAXX: Guarding the Genome against the Hazards of ALT
Genes (Basel). 2023 Mar. 24, v. 14, no. 4
2023
Abstract: Proliferating cells must enact a telomere maintenance mechanism to ensure genomic stability. In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of ... ...
Abstract | Proliferating cells must enact a telomere maintenance mechanism to ensure genomic stability. In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of Telomeres or ALT. The ALT process is linked to mutations in the ATRX/DAXX/H3.3 histone chaperone complex. This complex is responsible for depositing non-replicative histone variant H3.3 at pericentric and telomeric heterochromatin but has also been found to have roles in ameliorating replication in repeat sequences and in promoting DNA repair. In this review, we will discuss ways in which ATRX/DAXX helps to protect the genome, and how loss of this complex allows ALT to take hold. |
---|---|
Schlagwörter | DNA repair ; genome ; genomics ; heterochromatin ; histones ; telomerase ; telomeres |
Sprache | Englisch |
Erscheinungsverlauf | 2023-0324 |
Erscheinungsort | Multidisciplinary Digital Publishing Institute |
Dokumenttyp | Artikel ; Online |
ZDB-ID | 2527218-4 |
ISSN | 2073-4425 |
ISSN | 2073-4425 |
DOI | 10.3390/genes14040790 |
Datenquelle | NAL Katalog (AGRICOLA) |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.