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  1. Artikel ; Online: Tuberculosis Preventive Treatment Update - U.S. President's Emergency Plan for AIDS Relief, 36 Countries, 2016-2023.

    Ajiboye, Aderonke S / O'Connor, Stephanie / Smith, Jonathan P / Ahmedov, Sevim / Coggin, William L / Charles, Macarthur / Ghosh, Smita / Pierre, Paul / Shah, Neha / Teran, Richard A / Moonan, Patrick K / Date, Anand

    MMWR. Morbidity and mortality weekly report

    2024  Band 73, Heft 11, Seite(n) 233–238

    Abstract: Tuberculosis (TB) is the leading cause of death among persons with HIV. In 2022, an estimated 167,000 TB-related deaths occurred globally among persons with HIV. TB preventive treatment (TPT) helps prevent TB disease and is recommended for persons at ... ...

    Abstract Tuberculosis (TB) is the leading cause of death among persons with HIV. In 2022, an estimated 167,000 TB-related deaths occurred globally among persons with HIV. TB preventive treatment (TPT) helps prevent TB disease and is recommended for persons at high risk for developing TB, including those with HIV. TPT, when taken with antiretroviral treatment (ART), can reduce TB-attributable deaths among persons with HIV. In 2018, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) program committed to offer one course of TPT to all eligible clients receiving ART. This analysis describes trends in TPT initiation and completion among PEPFAR-supported programs in 36 countries in Africa, Central and South America, and Asia during fiscal years (FYs) 2017-2023. Overall, TPT initiation rates peaked in FY19, a possible sign of programmatic saturation. TPT initiation among clients who had been on ART <6 months reached 59%, and overall completion rates up to 87% were reported. Approximately 13 million persons with HIV have completed TPT since FY17, but widespread adoption of shorter regimens, patient-centered approaches, and electronic medical record systems might be needed to ensure full TPT coverage. Through PEPFAR's partnership with national HIV programs, TPT has become the standard of care for persons with HIV.
    Mesh-Begriff(e) Humans ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Acquired Immunodeficiency Syndrome/prevention & control ; International Cooperation ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Africa ; Anti-Retroviral Agents/therapeutic use
    Chemische Substanzen Anti-Retroviral Agents
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7311a1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Rolling Out Xpert

    Pathmanathan, Ishani / Date, Anand / Coggin, William L / Nkengasong, John / Piatek, Amy S / Alexander, Heather

    African journal of laboratory medicine

    2017  Band 6, Heft 2

    Abstract: Background: To eliminate preventable deaths, disease and suffering due to tuberculosis (TB), improved diagnostic capacity is critical. The Cepheid Xpert: Opportunities for system strengthening: In this commentary we discuss needs and opportunities ... ...

    Abstract Background: To eliminate preventable deaths, disease and suffering due to tuberculosis (TB), improved diagnostic capacity is critical. The Cepheid Xpert
    Opportunities for system strengthening: In this commentary we discuss needs and opportunities for systems strengthening to support widespread scale-up of Xpert
    Conclusion: Xpert
    Sprache Englisch
    Erscheinungsdatum 2017-07-18
    Erscheinungsland South Africa
    Dokumenttyp Journal Article
    ZDB-ID 2708535-1
    ISSN 2225-2010 ; 2225-2002
    ISSN (online) 2225-2010
    ISSN 2225-2002
    DOI 10.4102/ajlm.v6i2.460
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Role of the US President's Emergency Plan for AIDS Relief in responding to tuberculosis and HIV coinfection.

    Coggin, William L / Ryan, Caroline A / Holmes, Charles B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2010  Band 50 Suppl 3, Seite(n) S255–9

    Abstract: The intersection of tuberculosis (TB) and human immunodeficiency virus (HIV) infection has eroded gains made in TB control, because previously well-functioning national TB programs have been overwhelmed by the dual challenges posed by TB and HIV ... ...

    Abstract The intersection of tuberculosis (TB) and human immunodeficiency virus (HIV) infection has eroded gains made in TB control, because previously well-functioning national TB programs have been overwhelmed by the dual challenges posed by TB and HIV coinfection. The US President's Emergency Plan for AIDS Relief (PEPFAR), through its direct support of >2.4 million persons receiving HIV treatment and, in 2009, support of >308,000 HIV-infected persons receiving TB treatment, works closely with national governments and other partners to strengthen the response to TB and HIV coinfection. PEPFAR-supported activities fall within the World Health Organization's 2004 framework for collaborative TB and HIV activities, including critical interventions to (1) develop organizational methods of collaboration across the 2 programs, (2) reduce the burden of HIV infection among patients with TB, and (3) reduce the burden of TB among persons with HIV infection or AIDS. To date, PEPFAR and partners have made important gains in coverage and scope of HIV testing, referral, and antiretroviral therapy for patients with TB. TB screening of HIV-infected patients is also beginning to increase, although greater progress needs to be made in increasing access to isoniazid preventive therapy and strengthening TB infection control. Continued strategic integration of TB and HIV interventions into PEPFAR-supported programs is essential to easing the patient burden of dual infection, improving patient outcomes, and, ultimately, decreasing rates of TB in areas with a high prevalence of TB.
    Mesh-Begriff(e) AIDS-Related Opportunistic Infections/drug therapy ; AIDS-Related Opportunistic Infections/economics ; AIDS-Related Opportunistic Infections/epidemiology ; AIDS-Related Opportunistic Infections/prevention & control ; Communicable Disease Control/economics ; Financial Management/organization & administration ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/economics ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Tuberculosis/drug therapy ; Tuberculosis/economics ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; United States/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2010-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/651499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: GeneXpert for TB diagnosis: planned and purposeful implementation.

    Piatek, Amy S / Van Cleeff, Maarten / Alexander, Heather / Coggin, William L / Rehr, Manuela / Van Kampen, Sanne / Shinnick, Thomas M / Mukadi, YaDiul

    Global health, science and practice

    2013  Band 1, Heft 1, Seite(n) 18–23

    Abstract: Xpert MTB/RIF is a major advance for TB diagnostics, especially for multidrug-resistant (MDR) TB and HIV-associated TB. But implementation concerns including cost, technical support requirements, and challenging demands of providing second-line TB drugs ... ...

    Abstract Xpert MTB/RIF is a major advance for TB diagnostics, especially for multidrug-resistant (MDR) TB and HIV-associated TB. But implementation concerns including cost, technical support requirements, and challenging demands of providing second-line TB drugs for diagnosed MDR-TB cases call for gradual, careful introduction based on country circumstances.
    Sprache Englisch
    Erscheinungsdatum 2013-03-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2710875-2
    ISSN 2169-575X
    ISSN 2169-575X
    DOI 10.9745/GHSP-D-12-00004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: PEPFAR support for the scaling up of collaborative TB/HIV activities.

    Howard, Andrea A / Gasana, Michel / Getahun, Haileyesus / Harries, Anthony / Lawn, Stephen D / Miller, Bess / Nelson, Lisa / Sitienei, Joseph / Coggin, William L

    Journal of acquired immune deficiency syndromes (1999)

    2012  Band 60 Suppl 3, Seite(n) S136–44

    Abstract: The US President's Emergency Plan for AIDS Relief (PEPFAR) has supported a comprehensive package of care in which interventions to address HIV-related tuberculosis (TB) have received increased funding and support in recent years. PEPFAR's TB/HIV ... ...

    Abstract The US President's Emergency Plan for AIDS Relief (PEPFAR) has supported a comprehensive package of care in which interventions to address HIV-related tuberculosis (TB) have received increased funding and support in recent years. PEPFAR's TB/HIV programming is based on the World Health Organization's 12-point policy for collaborative TB/HIV activities, which are integrated into PEPFAR annual guidance. PEPFAR implementing partners have provided crucial support to TB/HIV collaboration, and as a result, PEPFAR-supported countries in sub-Saharan Africa have made significant gains in HIV testing and counseling of TB patients and linkages to HIV care and treatment, intensified TB case finding, and TB infection control. PEPFAR's support of TB/HIV integration has also included significant investment in health systems, including improved laboratory services and educating and enlarging the workforce. The scale-up of antiretroviral therapy along with support of programs to increase HIV counseling and testing and improve linkage and retention in HIV care may have considerable impact on TB morbidity and mortality, if used synergistically with isoniazid preventive therapy, intensified case finding, and infection control. Issues to be addressed by future programming include accelerating implementation of isoniazid preventive therapy, increasing access and ensuring appropriate use of new TB diagnostics, supporting early initiation of antiretroviral therapy for HIV-infected TB patients, and strengthening systems to monitor and evaluate program implementation.
    Mesh-Begriff(e) AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/drug therapy ; Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/drug therapy ; Africa South of the Sahara/epidemiology ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Communicable Disease Control/trends ; Developing Countries ; Global Health ; Humans ; International Cooperation ; National Health Programs/organization & administration ; National Health Programs/trends ; Public-Private Sector Partnerships/organization & administration ; Public-Private Sector Partnerships/trends ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; United States
    Sprache Englisch
    Erscheinungsdatum 2012-07-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0b013e31825cfe8e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Online: PEPFAR support for the scaling up of collaborative TB/HIV activities

    Sitienei, Joseph / Nelson, Lisa / Miller, Bess / Lawn, Stephen D / Harries, Anthony / Howard, Andrea A / Getahun, Haileyesus / Coggin, William L / Gasana, Michel

    2012  

    Abstract: Research Support, U.S. Gov't, P.H.S. ... Research Support, Non-U.S. Gov't ... Review ...

    Abstract Research Support, U.S. Gov't, P.H.S.

    Research Support, Non-U.S. Gov't

    Review

    Journal Article

    The US President's Emergency Plan for AIDS Relief (PEPFAR) has supported a comprehensive package of care in which interventions to address HIV-related tuberculosis (TB) have received increased funding and support in recent years. PEPFAR's TB/HIV programming is based on the World Health Organization's 12-point policy for collaborative TB/HIV activities, which are integrated into PEPFAR annual guidance. PEPFAR implementing partners have provided crucial support to TB/HIV collaboration, and as a result, PEPFAR-supported countries in sub-Saharan Africa have made significant gains in HIV testing and counseling of TB patients and linkages to HIV care and treatment, intensified TB case finding, and TB infection control. PEPFAR's support of TB/HIV integration has also included significant investment in health systems, including improved laboratory services and educating and enlarging the workforce. The scale-up of antiretroviral therapy along with support of programs to increase HIV counseling and testing and improve linkage and retention in HIV care may have considerable impact on TB morbidity and mortality, if used synergistically with isoniazid preventive therapy, intensified case finding, and infection control. Issues to be addressed by future programming include accelerating implementation of isoniazid preventive therapy, increasing access and ensuring appropriate use of new TB diagnostics, supporting early initiation of antiretroviral therapy for HIV-infected TB patients, and strengthening systems to monitor and evaluate program implementation.
    Sprache Englisch
    Erscheinungsdatum 2012-08-01
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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