Artikel ; Online: Full-length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients.
Journal of thrombosis and haemostasis : JTH
2022 Band 20, Heft 6, Seite(n) 1385–1389
Abstract: Background: Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic capacity has not been defined.: Objectives: We hypothesized that ... ...
| Abstract | Background: Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic capacity has not been defined. Objectives: We hypothesized that coagulopathy in acutely injured patients is associated with procoagulant plasma SkM heavy chain levels. Methods: To test this hypothesis, citrated whole blood and plasma from 104 trauma patients were collected and studied to obtain data for rapid thrombelastography, international normalized ratios, and plasma SkM levels. Coagulability parameters were dichotomized by the threshold for the hypercoagulable trauma-induced coagulopathy. Results: Lower plasma full-length SkM heavy chain (full-SkM) levels were associated with higher international normalized ratio values (>1.3) (p = .03). The full-SkM levels were also associated with a lower rate of clot propagation (thrombelastography angle <65°) (p = .004), and plasma full-SkM levels were positively correlated with the thrombelastography angle (r Conclusions: In acutely injured trauma patients, lower levels of plasma full-SkM levels are linked to hypocoagulability in trauma-induced coagulopathy, implying that SkM plays a role in the hemostatic capacity in trauma patients and may contribute to trauma-induced coagulopathy. |
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| Mesh-Begriff(e) | Blood Coagulation Disorders/etiology ; Hemostatics ; Humans ; Plasma ; Protein Isoforms ; Skeletal Muscle Myosins ; Thrombelastography ; Wounds and Injuries/complications |
| Chemische Substanzen | Hemostatics ; Protein Isoforms ; Skeletal Muscle Myosins (EC 3.6.1.-) |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-03-20 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2112661-6 |
| ISSN | 1538-7836 ; 1538-7933 |
| ISSN (online) | 1538-7836 |
| ISSN | 1538-7933 |
| DOI | 10.1111/jth.15695 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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