Artikel: Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion.
International journal of endocrinology
2017 Band 2017, Seite(n) 4138783
Abstract: Background: Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion.: Objective: To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in ... ...
Abstract | Background: Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. Objective: To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT). Methods: An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy. Results: A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protocol. Following 1 week of lisinopril, participants with P-HPT had a decrease in systolic blood pressure (SBP) (-6.4 mmHg, Conclusion: In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT. This trial is registered with ClinicalTrials.gov NCT01691781. |
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Sprache | Englisch |
Erscheinungsdatum | 2017-07-20 |
Erscheinungsland | Egypt |
Dokumenttyp | Journal Article |
ZDB-ID | 2502951-4 |
ISSN | 1687-8345 ; 1687-8337 |
ISSN (online) | 1687-8345 |
ISSN | 1687-8337 |
DOI | 10.1155/2017/4138783 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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