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  1. Artikel ; Online: Estimating human pharmacokinetic parameters forelectronic nicotine delivery system products from chemical analyses of their aerosols.

    Shiffman, Saul / Cohen, Gal / Liang, Qiwei / Cook, David K / Karles, Georgios D

    Drug testing and analysis

    2024  

    Abstract: The ability of Electronic Nicotine Delivery Systems (ENDS) to deliver nicotine is central to their function to substitute for cigarettes, allowing people who smoke to switch away from smoking, thus reducing their exposure to harmful chemicals in ... ...

    Abstract The ability of Electronic Nicotine Delivery Systems (ENDS) to deliver nicotine is central to their function to substitute for cigarettes, allowing people who smoke to switch away from smoking, thus reducing their exposure to harmful chemicals in cigarette smoke. The nicotine concentration in ENDS e-liquid has proved to be a poor predictor of nicotine uptake in users. Using meta-analytic methods to analyze 12 pharmacokinetic studies of nicotine-salt closed-system ENDS, this paper examines whether the mass of nicotine/puff of aerosol can predict C
    Sprache Englisch
    Erscheinungsdatum 2024-05-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3737
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Subcutaneous Sweet syndrome leading to the diagnosis of acute myeloid leukaemia.

    Ting, Samantha / Zhao, Cathy / Cook, David K

    Australian journal of general practice

    2022  Band 51, Heft 6, Seite(n) 391–393

    Mesh-Begriff(e) Diagnosis, Differential ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/diagnosis ; Sweet Syndrome/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-07-21-6099
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Chronic balanitis: When should we be concerned?

    Lam, Kevin / Cook, David K

    Australian journal of general practice

    2020  Band 49, Heft 12, Seite(n) 839–841

    Mesh-Begriff(e) Aged ; Balanitis/complications ; Balanitis/diagnosis ; Diagnosis, Differential ; Exanthema/etiology ; Exanthema/physiopathology ; Humans ; Male ; Penis/abnormalities
    Sprache Englisch
    Erscheinungsdatum 2020-11-27
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-03-20-5283
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Bullous eruption on the limbs in an elderly patient.

    Jiang, Kevin W / Zhao, Cathy Y / Lee, Kenneth M / Cook, David K

    Australian journal of general practice

    2022  Band 51, Heft 5, Seite(n) 338–339

    Mesh-Begriff(e) Aged ; Humans ; Patients ; Skin Diseases, Vesiculobullous/diagnosis ; Skin Diseases, Vesiculobullous/etiology
    Sprache Englisch
    Erscheinungsdatum 2022-05-01
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-02-21-5855
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  5. Artikel ; Online: A 10-year retrospective cohort study of the management of toxic epidermal necrolysis and Stevens-Johnson syndrome in a New South Wales state referral hospital from 2006 to 2016.

    Chan, Linda / Cook, David K

    International journal of dermatology

    2019  Band 58, Heft 10, Seite(n) 1141–1147

    Abstract: Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening severe cutaneous drug reactions. There have been no Australian data published since 2007.: Objective: To explore whether there is an association ... ...

    Abstract Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening severe cutaneous drug reactions. There have been no Australian data published since 2007.
    Objective: To explore whether there is an association between prognosis and the type of systemic immune-modulation treatment administered in a cohort of patients with SJS, SJS-TEN overlap, and TEN at the New South Wales State SJS/TEN referral center - Concord Repatriation General Hospital.
    Methods: This is a retrospective, single center, cohort study of patients admitted with SJS/TEN from January 1, 2006, to December 31, 2016, at Concord Repatriation General Hospital. Data on demographic information, the causative agent, treatment, and final survival outcome were analyzed.
    Results: Forty-two patients included: 26 (62%) with TEN, six (14%) with SJS/TEN overlap, and 10 (24%) with SJS. Overall mortality was 19% (n = 8), and seven suffered TEN. The average age of those who died was 60 years. Eighty-one percent of patients were managed within the burn unit. Twenty-nine patients (70%) received IVIG within this group; 13 individuals also received systemic corticosteroids. Seven (17%) were managed with corticosteroid therapy alone. The incidence of death was 0% in the combined IVIG and corticosteroid group.
    Conclusion: This series of 42 patients contributes valuable information to a serious condition with low global incidence and high mortality. There appears to be an apparent reduced mortality in the group of SJS/TEN patients managed with combined IVIG and corticosteroid. Larger cohorts are required to validate this relationship due to the risk of bias inherent to the retrospective study design and small sample size.
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Drug Therapy, Combination/methods ; Female ; Glucocorticoids/therapeutic use ; Hospital Mortality ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Kaplan-Meier Estimate ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; New South Wales/epidemiology ; Palliative Care/methods ; Prognosis ; Retrospective Studies ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/mortality ; Tertiary Care Centers/statistics & numerical data ; Treatment Outcome
    Chemische Substanzen Glucocorticoids ; Immunoglobulins, Intravenous
    Sprache Englisch
    Erscheinungsdatum 2019-03-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14426
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Female pattern hair loss.

    Chan, Linda / Cook, David K

    Australian journal of general practice

    2018  Band 47, Heft 7, Seite(n) 459–464

    Abstract: Background: Female pattern hair loss (FPHL) is a commonly encountered clinical presentation in primary care. Patterned hair loss in women is characterised by diffuse hair thinning and often becomes an ongoing cause of psychosocial distress.: Objective! ...

    Abstract Background: Female pattern hair loss (FPHL) is a commonly encountered clinical presentation in primary care. Patterned hair loss in women is characterised by diffuse hair thinning and often becomes an ongoing cause of psychosocial distress.
    Objective: The aim of this article is to present a practical approach for the clinical assessment of female hair loss and to review the up-to-date treatment modalities.
    Discussion: Alopecia can be the first symptom of systemic illness. It is therefore crucial for the primary care physician to be able to differentiate between FPHL and more concerning causes of hair loss. Treatment options often involve a combination of non-androgenic and androgenic therapy. The use of oral minoxidil in combination with oral spironolactone is a novel therapy with promising results. The role of the general practitioner is paramount in establishing the diagnosis, setting achievable therapeutic goals and navigating the psychosocial comorbidity associated with this chronic condition.
    Mesh-Begriff(e) 5-alpha Reductase Inhibitors/therapeutic use ; Adult ; Alopecia/drug therapy ; Alopecia/etiology ; Alopecia/physiopathology ; Androgen Receptor Antagonists/therapeutic use ; Female ; Humans ; Minoxidil/therapeutic use ; Risk Factors ; Spironolactone/therapeutic use ; Vasodilator Agents/therapeutic use
    Chemische Substanzen 5-alpha Reductase Inhibitors ; Androgen Receptor Antagonists ; Vasodilator Agents ; Spironolactone (27O7W4T232) ; Minoxidil (5965120SH1)
    Sprache Englisch
    Erscheinungsdatum 2018-08-16
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-02-18-4498
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A Practical Framework for Novel Electronic Nicotine Delivery System Evaluation: Chemical and Toxicological Characterization of JUUL2 Aerosol and Comparison with Reference Cigarettes.

    Cook, David K / Lalonde, Guy / Oldham, Michael J / Wang, Jiaming / Bates, Austin / Ullah, Sifat / Sulaiman, Christina / Carter, Karen / Jongsma, Candice / Dull, Gary / Gillman, I Gene

    Toxics

    2024  Band 12, Heft 1

    Abstract: Electronic nicotine delivery systems (ENDSs) are designed as a non-combustible alternative to cigarettes, aiming to deliver nicotine without the harmful byproducts of tobacco combustion. As the category evolves and new ENDS products emerge, it is ... ...

    Abstract Electronic nicotine delivery systems (ENDSs) are designed as a non-combustible alternative to cigarettes, aiming to deliver nicotine without the harmful byproducts of tobacco combustion. As the category evolves and new ENDS products emerge, it is important to continually assess the levels of toxicologically relevant chemicals in the aerosols and characterize any related toxicology. Herein, we present a proposed framework for characterizing novel ENDS products (i.e., devices and formulations) and determining the reduced risk potential utilizing analytical chemistry and in vitro toxicological studies with a qualitative risk assessment. To demonstrate this proposed framework, long-term stability studies (12 months) analyzing relevant toxicant emissions from six formulations of a next-generation product, JUUL2, were conducted and compared to reference combustible cigarette (CC) smoke under both non-intense and intense puffing regimes. In addition, in vitro cytotoxicity, mutagenicity, and genotoxicity assays were conducted on aerosol and smoke condensates. In all samples, relevant toxicants under both non-intense and intense puffing regimes were substantially lower than those observed in reference CC smoke. Furthermore, neither cytotoxicity, mutagenicity, nor genotoxicity was observed in aerosol condensates generated under both intense and non-intense puffing regimes, in contrast to results observed for reference cigarettes. Following the proposed framework, the results demonstrate that the ENDS products studied in this work generate significantly lower levels of toxicants relative to reference cigarettes and were not cytotoxic, mutagenic, or genotoxic under these in vitro assay conditions.
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12010041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Eruptive Bowen's Disease in a patient on pembrolizumab for Hodgkin's lymphoma.

    Jiang, Kevin W / Zhao, Cathy Y / Chan, Charles / Peduto, Monica Y / Kailainathan, Gajan / Cook, David K

    The Australasian journal of dermatology

    2021  Band 62, Heft 3, Seite(n) e435–e437

    Mesh-Begriff(e) Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; Bowen's Disease/pathology ; Hodgkin Disease/drug therapy ; Humans ; Male ; Skin Neoplasms/diagnosis ; Treatment Outcome
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Sprache Englisch
    Erscheinungsdatum 2021-07-03
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13652
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  9. Artikel: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive.

    Chan, Linda / Chan, Charles / Cook, David K

    JAAD case reports

    2018  Band 4, Heft 2, Seite(n) 170–174

    Sprache Englisch
    Erscheinungsdatum 2018-01-24
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.10.007
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  10. Artikel: Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis.

    Jameson, J Brian / Wang, Jiaming / Bailey, Patrick C / Oldham, Michael J / Smith, Cameron R / Jeong, Lena N / Cook, David K / Bates, Austin L / Ullah, Sifat / Pennington, Alexander S C / Gillman, I Gene

    Frontiers in chemistry

    2023  Band 11, Seite(n) 1223967

    Abstract: Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often ... ...

    Abstract Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50-100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested.
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1223967
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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