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  1. Artikel ; Online: Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial.

    Qiu, Miao-Zhen / Oh, Do-Youn / Kato, Ken / Arkenau, Tobias / Tabernero, Josep / Correa, Marcia Cruz / Zimina, Anastasia V / Bai, Yuxian / Shi, Jianhua / Lee, Keun-Wook / Wang, Jufeng / Poddubskaya, Elena / Pan, Hongming / Rha, Sun Young / Zhang, Ruixing / Hirano, Hidekazu / Spigel, David / Yamaguchi, Kensei / Chao, Yee /
    Wyrwicz, Lucjan / Disel, Umut / Cid, Roberto Pazo / Fornaro, Lorenzo / Evesque, Ludovic / Wang, Hongwei / Xu, Yaling / Li, Jiang / Sheng, Tao / Yang, Silu / Li, Liyun / Moehler, Markus / Xu, Rui-Hua

    BMJ (Clinical research ed.)

    2024  Band 385, Seite(n) e078876

    Abstract: Objective: To evaluate the efficacy and safety of tislelizumab added to chemotherapy as first line (primary) treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma compared with placebo plus chemotherapy.: Design: Randomised, ... ...

    Abstract Objective: To evaluate the efficacy and safety of tislelizumab added to chemotherapy as first line (primary) treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma compared with placebo plus chemotherapy.
    Design: Randomised, double blind, placebo controlled, phase 3 study.
    Setting: 146 medical centres across Asia, Europe, and North America, between 13 December 2018 and 28 February 2023.
    Participants: 1657 patients aged ≥18 years with human epidermal growth factor receptor 2 negative locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma, regardless of programmed death-ligand 1 (PD-L1) expression status, who had not received systemic anticancer therapy for advanced disease.
    Interventions: Patients were randomly (1:1) assigned to receive either tislelizumab 200 mg or placebo intravenously every three weeks in combination with chemotherapy (investigator's choice of oxaliplatin and capecitabine, or cisplatin and 5-fluorouracil) and stratified by region, PD-L1 expression, presence or absence of peritoneal metastases, and investigator's choice of chemotherapy. Treatment continued until disease progression or unacceptable toxicity.
    Main outcome measures: The primary endpoint was overall survival, both in patients with a PD-L1 tumour area positivity (TAP) score of ≥5% and in all randomised patients. Safety was assessed in all those who received at least one dose of study treatment.
    Results: Of 1657 patients screened between 13 December 2018 and 9 February 2021, 660 were ineligible due to not meeting the eligibility criteria, withdrawal of consent, adverse events, or other reasons. Overall, 997 were randomly assigned to receive tislelizumab plus chemotherapy (n=501) or placebo plus chemotherapy (n=496). Tislelizumab plus chemotherapy showed statistically significant improvements in overall survival versus placebo plus chemotherapy in patients with a PD-L1 TAP score of ≥5% (median 17.2 months
    Conclusions: Tislelizumab added to chemotherapy as primary treatment for advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma provided superior overall survival with a manageable safety profile versus placebo plus chemotherapy in patients with a PD-L1 TAP score of ≥5%, and in all randomised patients.
    Trial registration: ClinicalTrials.gov NCT03777657.
    Mesh-Begriff(e) Humans ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/therapeutic use ; Male ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Adenocarcinoma/mortality ; Female ; Middle Aged ; Double-Blind Method ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/mortality ; Esophagogastric Junction/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aged ; Adult ; Cisplatin/administration & dosage ; Cisplatin/therapeutic use ; Capecitabine/administration & dosage ; Capecitabine/therapeutic use ; Fluorouracil/administration & dosage ; Fluorouracil/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; tislelizumab (0KVO411B3N) ; Cisplatin (Q20Q21Q62J) ; Capecitabine (6804DJ8Z9U) ; Fluorouracil (U3P01618RT)
    Sprache Englisch
    Erscheinungsdatum 2024-05-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Clinical Trial, Phase III ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2023-078876
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Association between calcium intake and colorectal neoplasia in Puerto Rican Hispanics.

    Palacios, Cristina / Lopez, Maritza / Ortiz, Ana Patricia / Correa, Marcia Cruz

    Archivos latinoamericanos de nutricion

    2011  Band 60, Heft 4, Seite(n) 348–354

    Abstract: Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of ...

    Abstract Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of this cross-sectional study, a total of 433 subjects were recruited from surgery and gastroenterology clinics at the University of Puerto Rico. Calcium intake was estimated using a food frequency questionnaire (FFQ) of calcium rich foods. Socio-demographics, health history and colonoscopy results were obtained from the primary study. Chi square and odds ratios (OR) for colorectal neoplasia (adenomas and/ or adenocarcinoma) were calculated for total calcium, dietary calcium and for calcium supplement use. In total, 312 (72%) from 433 participants completed the FFQ and had available colonoscopy results; from these, 196 (62.5%) were free of neoplasia and 117 (37.5%) had colorectal neoplasia. Colorectal neoplasia subjects were older, a lower proportion were females and less educated than those without neoplasia (p < 0.01). Total calcium intake (median 1180 mg/d) was greater in those free of neoplasia compared to colorectal neoplasia subjects (median 1036 mg/d; p<0.05). A high total calcium intake and the use of calcium supplements significantly reduced the OR (crude and age adjusted) for colorectal neoplasia; although these associations lost statistical significance after additionally adjusting for gender and educational level. In conclusion, a high calcium intake and the use of calcium supplements may be protective against colorectal neoplasia, although a greater sample may be required to observe significant associations in a multivariate model.
    Mesh-Begriff(e) Aged ; Calcium, Dietary/administration & dosage ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Cross-Sectional Studies ; Diet Records ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Puerto Rico/epidemiology
    Chemische Substanzen Calcium, Dietary
    Sprache Englisch
    Erscheinungsdatum 2011-08-22
    Erscheinungsland Venezuela
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 194741-2
    ISSN 0004-0622
    ISSN 0004-0622
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Early Detection for Colorectal Cancer: ASCO Resource-Stratified Guideline.

    Lopes, Gilberto / Stern, Mariana C / Temin, Sarah / Sharara, Ala I / Cervantes, Andres / Costas-Chavarri, Ainhoa / Engineer, Rena / Hamashima, Chisato / Ho, Gwo Fuang / Huitzil, Fidel David / Moghani, Mona Malekzadeh / Nandakumar, Govind / Shah, Manish A / Teh, Catherine / Manjarrez, Sara E Vázquez / Verjee, Azmina / Yantiss, Rhonda / Correa, Marcia Cruz

    Journal of global oncology

    2019  Band 5, Seite(n) 1–22

    Abstract: Purpose: To provide resource-stratified, evidence-based recommendations on the early detection of colorectal cancer in four tiers to clinicians, patients, and caregivers.: Methods: American Society of Clinical Oncology convened a multidisciplinary, ... ...

    Abstract Purpose: To provide resource-stratified, evidence-based recommendations on the early detection of colorectal cancer in four tiers to clinicians, patients, and caregivers.
    Methods: American Society of Clinical Oncology convened a multidisciplinary, multinational panel of medical oncology, surgical oncology, surgery, gastroenterology, health technology assessment, cancer epidemiology, pathology, radiology, radiation oncology, and patient advocacy experts. The Expert Panel reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus-based process with additional experts (Consensus Ratings Group) for two round(s) of formal ratings.
    Results: Existing sets of guidelines from eight guideline developers were identified and reviewed; adapted recommendations form the evidence base. These guidelines, along with cost-effectiveness analyses, provided evidence to inform the formal consensus process, which resulted in agreement of 75% or more.
    Conclusion: In nonmaximal settings, for people who are asymptomatic, are ages 50 to 75 years, have no family history of colorectal cancer, are at average risk, and are in settings with high incidences of colorectal cancer, the following screening options are recommended: guaiac fecal occult blood test and fecal immunochemical testing (basic), flexible sigmoidoscopy (add option in limited), and colonoscopy (add option in enhanced). Optimal reflex testing strategy for persons with positive screens is as follows: endoscopy; if not available, barium enema (basic or limited). Management of polyps in enhanced is as follows: colonoscopy, polypectomy; if not suitable, then surgical resection. For workup and diagnosis of people with symptoms, physical exam with digital rectal examination, double contrast barium enema (only in basic and limited); colonoscopy; flexible sigmoidoscopy with biopsy (if contraindication to latter) or computed tomography colonography if contraindications to two endoscopies (enhanced only).
    Mesh-Begriff(e) Age Factors ; Aged ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Early Detection of Cancer/standards ; Health Resources/standards ; Humans ; International Cooperation ; Middle Aged ; Practice Guidelines as Topic/standards ; Risk Factors ; Societies, Medical
    Sprache Englisch
    Erscheinungsdatum 2019-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2378-9506
    ISSN (online) 2378-9506
    DOI 10.1200/JGO.18.00213
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A review of cancer in U.S. Hispanic populations.

    Haile, Robert W / John, Esther M / Levine, A Joan / Cortessis, Victoria K / Unger, Jennifer B / Gonzales, Melissa / Ziv, Elad / Thompson, Patricia / Spruijt-Metz, Donna / Tucker, Katherine L / Bernstein, Jonine L / Rohan, Thomas E / Ho, Gloria Y F / Bondy, Melissa L / Martinez, Maria Elena / Cook, Linda / Stern, Mariana C / Correa, Marcia Cruz / Wright, Jonelle /
    Schwartz, Seth J / Baezconde-Garbanati, Lourdes / Blinder, Victoria / Miranda, Patricia / Hayes, Richard / Friedman-Jiménez, George / Monroe, Kristine R / Haiman, Christopher A / Henderson, Brian E / Thomas, Duncan C / Boffetta, Paolo

    Cancer prevention research (Philadelphia, Pa.)

    2012  Band 5, Heft 2, Seite(n) 150–163

    Abstract: There are compelling reasons to conduct studies of cancer in Hispanics, the fastest growing major demographic group in the United States (from 15% to 30% of the U.S. population by 2050). The genetically admixed Hispanic population coupled with secular ... ...

    Abstract There are compelling reasons to conduct studies of cancer in Hispanics, the fastest growing major demographic group in the United States (from 15% to 30% of the U.S. population by 2050). The genetically admixed Hispanic population coupled with secular trends in environmental exposures and lifestyle/behavioral practices that are associated with immigration and acculturation offer opportunities for elucidating the effects of genetics, environment, and lifestyle on cancer risk and identifying novel risk factors. For example, traditional breast cancer risk factors explain less of the breast cancer risk in Hispanics than in non-Hispanic whites (NHW), and there is a substantially greater proportion of never-smokers with lung cancer in Hispanics than in NHW. Hispanics have higher incidence rates for cancers of the cervix, stomach, liver, and gall bladder than NHW. With respect to these cancers, there are intriguing patterns that warrant study (e.g., depending on country of origin, the five-fold difference in gastric cancer rates for Hispanic men but not Hispanic women). Also, despite a substantially higher incidence rate and increasing secular trend for liver cancer in Hispanics, there have been no studies of Hispanics reported to date. We review the literature and discuss study design options and features that should be considered in future studies.
    Mesh-Begriff(e) Hispanic Americans/statistics & numerical data ; Humans ; Neoplasms/epidemiology ; Registries ; United States/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2012-02-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-11-0447
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

    Jiang, Xia / Finucane, Hilary K / Schumacher, Fredrick R / Schmit, Stephanie L / Tyrer, Jonathan P / Han, Younghun / Michailidou, Kyriaki / Lesseur, Corina / Kuchenbaecker, Karoline B / Dennis, Joe / Conti, David V / Casey, Graham / Gaudet, Mia M / Huyghe, Jeroen R / Albanes, Demetrius / Aldrich, Melinda C / Andrew, Angeline S / Andrulis, Irene L / Anton-Culver, Hoda /
    Antoniou, Antonis C / Antonenkova, Natalia N / Arnold, Susanne M / Aronson, Kristan J / Arun, Banu K / Bandera, Elisa V / Barkardottir, Rosa B / Barnes, Daniel R / Batra, Jyotsna / Beckmann, Matthias W / Benitez, Javier / Benlloch, Sara / Berchuck, Andrew / Berndt, Sonja I / Bickeböller, Heike / Bien, Stephanie A / Blomqvist, Carl / Boccia, Stefania / Bogdanova, Natalia V / Bojesen, Stig E / Bolla, Manjeet K / Brauch, Hiltrud / Brenner, Hermann / Brenton, James D / Brook, Mark N / Brunet, Joan / Brunnström, Hans / Buchanan, Daniel D / Burwinkel, Barbara / Butzow, Ralf / Cadoni, Gabriella / Caldés, Trinidad / Caligo, Maria A / Campbell, Ian / Campbell, Peter T / Cancel-Tassin, Géraldine / Cannon-Albright, Lisa / Campa, Daniele / Caporaso, Neil / Carvalho, André L / Chan, Andrew T / Chang-Claude, Jenny / Chanock, Stephen J / Chen, Chu / Christiani, David C / Claes, Kathleen B M / Claessens, Frank / Clements, Judith / Collée, J Margriet / Correa, Marcia Cruz / Couch, Fergus J / Cox, Angela / Cunningham, Julie M / Cybulski, Cezary / Czene, Kamila / Daly, Mary B / deFazio, Anna / Devilee, Peter / Diez, Orland / Gago-Dominguez, Manuela / Donovan, Jenny L / Dörk, Thilo / Duell, Eric J / Dunning, Alison M / Dwek, Miriam / Eccles, Diana M / Edlund, Christopher K / Edwards, Digna R Velez / Ellberg, Carolina / Evans, D Gareth / Fasching, Peter A / Ferris, Robert L / Liloglou, Triantafillos / Figueiredo, Jane C / Fletcher, Olivia / Fortner, Renée T / Fostira, Florentia / Franceschi, Silvia / Friedman, Eitan / Gallinger, Steven J / Ganz, Patricia A / Garber, Judy / García-Sáenz, José A / Gayther, Simon A / Giles, Graham G / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / Goode, Ellen L / Goodman, Marc T / Goodman, Gary / Grankvist, Kjell / Greene, Mark H / Gronberg, Henrik / Gronwald, Jacek / Guénel, Pascal / Håkansson, Niclas / Hall, Per / Hamann, Ute / Hamdy, Freddie C / Hamilton, Robert J / Hampe, Jochen / Haugen, Aage / Heitz, Florian / Herrero, Rolando / Hillemanns, Peter / Hoffmeister, Michael / Høgdall, Estrid / Hong, Yun-Chul / Hopper, John L / Houlston, Richard / Hulick, Peter J / Hunter, David J / Huntsman, David G / Idos, Gregory / Imyanitov, Evgeny N / Ingles, Sue Ann / Isaacs, Claudine / Jakubowska, Anna / James, Paul / Jenkins, Mark A / Johansson, Mattias / Johansson, Mikael / John, Esther M / Joshi, Amit D / Kaneva, Radka / Karlan, Beth Y / Kelemen, Linda E / Kühl, Tabea / Khaw, Kay-Tee / Khusnutdinova, Elza / Kibel, Adam S / Kiemeney, Lambertus A / Kim, Jeri / Kjaer, Susanne K / Knight, Julia A / Kogevinas, Manolis / Kote-Jarai, Zsofia / Koutros, Stella / Kristensen, Vessela N / Kupryjanczyk, Jolanta / Lacko, Martin / Lam, Stephan / Lambrechts, Diether / Landi, Maria Teresa / Lazarus, Philip / Le, Nhu D / Lee, Eunjung / Lejbkowicz, Flavio / Lenz, Heinz-Josef / Leslie, Goska / Lessel, Davor / Lester, Jenny / Levine, Douglas A / Li, Li / Li, Christopher I / Lindblom, Annika / Lindor, Noralane M / Liu, Geoffrey / Loupakis, Fotios / Lubiński, Jan / Maehle, Lovise / Maier, Christiane / Mannermaa, Arto / Marchand, Loic Le / Margolin, Sara / May, Taymaa / McGuffog, Lesley / Meindl, Alfons / Middha, Pooja / Miller, Austin / Milne, Roger L / MacInnis, Robert J / Modugno, Francesmary / Montagna, Marco / Moreno, Victor / Moysich, Kirsten B / Mucci, Lorelei / Muir, Kenneth / Mulligan, Anna Marie / Nathanson, Katherine L / Neal, David E / Ness, Andrew R / Neuhausen, Susan L / Nevanlinna, Heli / Newcomb, Polly A / Newcomb, Lisa F / Nielsen, Finn Cilius / Nikitina-Zake, Liene / Nordestgaard, Børge G / Nussbaum, Robert L / Offit, Kenneth / Olah, Edith / Olama, Ali Amin Al / Olopade, Olufunmilayo I / Olshan, Andrew F / Olsson, Håkan / Osorio, Ana / Pandha, Hardev / Park, Jong Y / Pashayan, Nora / Parsons, Michael T / Pejovic, Tanja / Penney, Kathryn L / Peters, Wilbert H M / Phelan, Catherine M / Phipps, Amanda I / Plaseska-Karanfilska, Dijana / Pring, Miranda / Prokofyeva, Darya / Radice, Paolo / Stefansson, Kari / Ramus, Susan J / Raskin, Leon / Rennert, Gad / Rennert, Hedy S / van Rensburg, Elizabeth J / Riggan, Marjorie J / Risch, Harvey A / Risch, Angela / Roobol, Monique J / Rosenstein, Barry S / Rossing, Mary Anne / De Ruyck, Kim / Saloustros, Emmanouil / Sandler, Dale P / Sawyer, Elinor J / Schabath, Matthew B / Schleutker, Johanna / Schmidt, Marjanka K / Setiawan, V Wendy / Shen, Hongbing / Siegel, Erin M / Sieh, Weiva / Singer, Christian F / Slattery, Martha L / Sorensen, Karina Dalsgaard / Southey, Melissa C / Spurdle, Amanda B / Stanford, Janet L / Stevens, Victoria L / Stintzing, Sebastian / Stone, Jennifer / Sundfeldt, Karin / Sutphen, Rebecca / Swerdlow, Anthony J / Tajara, Eloiza H / Tangen, Catherine M / Tardon, Adonina / Taylor, Jack A / Teare, M Dawn / Teixeira, Manuel R / Terry, Mary Beth / Terry, Kathryn L / Thibodeau, Stephen N / Thomassen, Mads / Bjørge, Line / Tischkowitz, Marc / Toland, Amanda E / Torres, Diana / Townsend, Paul A / Travis, Ruth C / Tung, Nadine / Tworoger, Shelley S / Ulrich, Cornelia M / Usmani, Nawaid / Vachon, Celine M / Van Nieuwenhuysen, Els / Vega, Ana / Aguado-Barrera, Miguel Elías / Wang, Qin / Webb, Penelope M / Weinberg, Clarice R / Weinstein, Stephanie / Weissler, Mark C / Weitzel, Jeffrey N / West, Catharine M L / White, Emily / Whittemore, Alice S / Wichmann, H-Erich / Wiklund, Fredrik / Winqvist, Robert / Wolk, Alicja / Woll, Penella / Woods, Michael / Wu, Anna H / Wu, Xifeng / Yannoukakos, Drakoulis / Zheng, Wei / Zienolddiny, Shanbeh / Ziogas, Argyrios / Zorn, Kristin K / Lane, Jacqueline M / Saxena, Richa / Thomas, Duncan / Hung, Rayjean J / Diergaarde, Brenda / McKay, James / Peters, Ulrike / Hsu, Li / García-Closas, Montserrat / Eeles, Rosalind A / Chenevix-Trench, Georgia / Brennan, Paul J / Haiman, Christopher A / Simard, Jacques / Easton, Douglas F / Gruber, Stephen B / Pharoah, Paul D P / Price, Alkes L / Pasaniuc, Bogdan / Amos, Christopher I / Kraft, Peter / Lindström, Sara

    Nature communications

    2019  Band 10, Heft 1, Seite(n) 4386

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Sprache Englisch
    Erscheinungsdatum 2019-09-23
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-12095-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Shared heritability and functional enrichment across six solid cancers.

    Jiang, Xia / Finucane, Hilary K / Schumacher, Fredrick R / Schmit, Stephanie L / Tyrer, Jonathan P / Han, Younghun / Michailidou, Kyriaki / Lesseur, Corina / Kuchenbaecker, Karoline B / Dennis, Joe / Conti, David V / Casey, Graham / Gaudet, Mia M / Huyghe, Jeroen R / Albanes, Demetrius / Aldrich, Melinda C / Andrew, Angeline S / Andrulis, Irene L / Anton-Culver, Hoda /
    Antoniou, Antonis C / Antonenkova, Natalia N / Arnold, Susanne M / Aronson, Kristan J / Arun, Banu K / Bandera, Elisa V / Barkardottir, Rosa B / Barnes, Daniel R / Batra, Jyotsna / Beckmann, Matthias W / Benitez, Javier / Benlloch, Sara / Berchuck, Andrew / Berndt, Sonja I / Bickeböller, Heike / Bien, Stephanie A / Blomqvist, Carl / Boccia, Stefania / Bogdanova, Natalia V / Bojesen, Stig E / Bolla, Manjeet K / Brauch, Hiltrud / Brenner, Hermann / Brenton, James D / Brook, Mark N / Brunet, Joan / Brunnström, Hans / Buchanan, Daniel D / Burwinkel, Barbara / Butzow, Ralf / Cadoni, Gabriella / Caldés, Trinidad / Caligo, Maria A / Campbell, Ian / Campbell, Peter T / Cancel-Tassin, Géraldine / Cannon-Albright, Lisa / Campa, Daniele / Caporaso, Neil / Carvalho, André L / Chan, Andrew T / Chang-Claude, Jenny / Chanock, Stephen J / Chen, Chu / Christiani, David C / Claes, Kathleen B M / Claessens, Frank / Clements, Judith / Collée, J Margriet / Correa, Marcia Cruz / Couch, Fergus J / Cox, Angela / Cunningham, Julie M / Cybulski, Cezary / Czene, Kamila / Daly, Mary B / deFazio, Anna / Devilee, Peter / Diez, Orland / Gago-Dominguez, Manuela / Donovan, Jenny L / Dörk, Thilo / Duell, Eric J / Dunning, Alison M / Dwek, Miriam / Eccles, Diana M / Edlund, Christopher K / Edwards, Digna R Velez / Ellberg, Carolina / Evans, D Gareth / Fasching, Peter A / Ferris, Robert L / Liloglou, Triantafillos / Figueiredo, Jane C / Fletcher, Olivia / Fortner, Renée T / Fostira, Florentia / Franceschi, Silvia / Friedman, Eitan / Gallinger, Steven J / Ganz, Patricia A / Garber, Judy / García-Sáenz, José A / Gayther, Simon A / Giles, Graham G / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / Goode, Ellen L / Goodman, Marc T / Goodman, Gary / Grankvist, Kjell / Greene, Mark H / Gronberg, Henrik / Gronwald, Jacek / Guénel, Pascal / Håkansson, Niclas / Hall, Per / Hamann, Ute / Hamdy, Freddie C / Hamilton, Robert J / Hampe, Jochen / Haugen, Aage / Heitz, Florian / Herrero, Rolando / 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    Nature communications

    2019  Band 10, Heft 1, Seite(n) 431

    Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 ... ...

    Abstract Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r
    Mesh-Begriff(e) Breast Neoplasms/diagnosis ; Breast Neoplasms/ethnology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/ethnology ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Humans ; Inheritance Patterns ; Lung Neoplasms/diagnosis ; Lung Neoplasms/ethnology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Mental Disorders/ethnology ; Mental Disorders/genetics ; Mental Disorders/physiopathology ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/ethnology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Phenotype ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Smoking/ethnology ; Smoking/genetics ; Smoking/physiopathology ; White People
    Chemische Substanzen Neoplasm Proteins
    Sprache Englisch
    Erscheinungsdatum 2019-01-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-08054-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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