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  1. AU="Curling, P E"
  2. AU="Debraine, Arnaud"
  3. AU="Lambe, Cecile"
  4. AU="Jeong, Haneal"
  5. AU="Afaque, Syed Muhammad"
  6. AU=Layer Ryan M.
  7. AU="Rotaru, Luciana Teodora"
  8. AU="Nash, Kevin M"
  9. AU="Kubo, Sousuke"
  10. AU="Ingo Eitel"
  11. AU="van der Horst, A."
  12. AU="Di Mattia, A" AU="Di Mattia, A"
  13. AU="Di Pumpo, Marcello"
  14. AU="Doung, Yee-Cheen"
  15. AU="Saha, Moumita"
  16. AU="Wertz, Ashlee E"
  17. AU="Cowan, Michael J"
  18. AU=Togliatto Gabriele
  19. AU="Bassett, Dani S."
  20. AU="James Lemon"
  21. AU="Gros, Stephanie J"
  22. AU="Saeed Khademi"
  23. AU="Lallet-Daher, Helene"
  24. AU="Greenblatt, M"
  25. AU="Patwa, Ajay K"
  26. AU=Mastaglia F L
  27. AU="De Croock, Femke"
  28. AU=Robinson Michael J
  29. AU=Singh Romil
  30. AU="Martin, S J"
  31. AU="Szendrői, Miklós"
  32. AU="Moncel, Marie-Hélène"
  33. AU=Otu Akaninyene AU=Otu Akaninyene
  34. AU="Chiba, Kentaro"
  35. AU="Zhou, Jihua"
  36. AU="Ronald Bartels"
  37. AU="Liñares, J"
  38. AU="Valle, Valentina"
  39. AU="Tóth, András"
  40. AU="Pawar, Atul Darasing"
  41. AU="Semper, Chelsea"
  42. AU="Kraus, Joanne F"

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  1. Artikel: Nitric oxide-synthesizing perivascular nerves in the rat middle cerebral artery.

    Ignacio, C S / Curling, P E / Childres, W F / Bryan, R M

    The American journal of physiology

    1997  Band 273, Heft 2 Pt 2, Seite(n) R661–8

    Abstract: Although perivascular nerves containing nitric oxide synthase (NOS) have been anatomically described for rat cerebral arteries, a dilator function for these nerves has eluded investigators when using isolated vessels. Rat middle cerebral arteries (MCAs) ... ...

    Abstract Although perivascular nerves containing nitric oxide synthase (NOS) have been anatomically described for rat cerebral arteries, a dilator function for these nerves has eluded investigators when using isolated vessels. Rat middle cerebral arteries (MCAs) were isolated, pressurized, and electrically stimulated. The resting diameter of the MCAs after pressurization was 233 +/- 4 microns (n = 17) in one study. The MCAs showed a frequency-dependent dilation when stimulated. Maximum dilation (25-30% increase in diameter) occurred at a frequency of 8-16 Hz. Removal of endothelium or glibenclamide (10(-5) M), a blocker of ATP-sensitive potassium channels, had no effect on the dilations. The dilations were completely blocked with NG-nitro-L-arginine methyl ester (L-NAME) (10(-5) M), a general NOS inhibitor, and cold storage (24 h). The inhibition by L-NAME could be reversed by the addition of 10(-8) M L-arginine, the active precursor of NOS. Furthermore, 7-nitroindazole (10(-4) M), an inhibitor specific for the neuronal isoform of NOS, reduced the dilations by 43% (P < 0.05). Transections of nerve bundles originating from the sphenopalatine ganglia at the ethmoidal foramen blocked the dilations produced by electrical stimulations. We conclude that rat cerebral arteries have functionally intact perivascular nerves that dilate by releasing nitric oxide.
    Mesh-Begriff(e) Animals ; Arginine/pharmacology ; Cerebral Arteries/drug effects ; Cerebral Arteries/innervation ; Electric Stimulation ; Enzyme Inhibitors/pharmacology ; In Vitro Techniques ; Indazoles/pharmacology ; Male ; NG-Nitroarginine Methyl Ester/pharmacology ; Nervous System/metabolism ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Rats, Inbred Strains ; Vasodilation/drug effects
    Chemische Substanzen Enzyme Inhibitors ; Indazoles ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F) ; Nitric Oxide Synthase (EC 1.14.13.39) ; 7-nitroindazole (UX0N37CMVH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Sprache Englisch
    Erscheinungsdatum 1997-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2948-8
    ISSN 0002-9513
    ISSN 0002-9513
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Indications and uses of intravenous nitroglycerin during cardiac surgery.

    Curling, P E / Kaplan, J A

    Angiology

    1982  Band 33, Heft 5, Seite(n) 302–312

    Mesh-Begriff(e) Cardiopulmonary Bypass/methods ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Coronary Disease/complications ; Coronary Disease/drug therapy ; Coronary Disease/metabolism ; Drug Therapy ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/etiology ; Infusions, Parenteral ; Nitroglycerin/administration & dosage ; Nitroglycerin/therapeutic use ; Postoperative Complications/etiology ; Pulmonary Wedge Pressure/drug effects
    Chemische Substanzen Nitroglycerin (G59M7S0WS3)
    Sprache Englisch
    Erscheinungsdatum 1982-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80040-5
    ISSN 0003-3197
    ISSN 0003-3197
    DOI 10.1177/000331978203300503
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Severe preeclampsia: hemodynamic effects of lumbar epidural anesthesia.

    Newsome, L R / Bramwell, R S / Curling, P E

    Anesthesia and analgesia

    1986  Band 65, Heft 1, Seite(n) 31–36

    Abstract: The hemodynamic effects of lumbar epidural anesthesia (LEA) were evaluated in 11 patients with severe preeclampsia. All patients were receiving magnesium sulfate upon entry into the study. Hemodynamic measurements were obtained before and after LEA, at ... ...

    Abstract The hemodynamic effects of lumbar epidural anesthesia (LEA) were evaluated in 11 patients with severe preeclampsia. All patients were receiving magnesium sulfate upon entry into the study. Hemodynamic measurements were obtained before and after LEA, at delivery, and 2 hr postpartum. Lumbar epidural anesthesia significantly reduced mean arterial pressure from 121.4 mm Hg to 97.7 mm Hg, without altering cardiac index, pulmonary vascular resistance, central venous pressure (CVP), or pulmonary capillary wedge pressure (PCWP). There was a slight but statistically insignificant decrease in systemic vascular resistance from 1078 to 900.7 dynes X sec X cm-5. Cardiac index and left ventricular stroke work index were elevated in these patients, suggesting hyperdynamic left ventricular function. There was poor correlation between PCWP and CVP in several patients. We conclude that LEA may be used safely in severe preeclamptic patients and that pulmonary arterial catheters may help guide appropriate therapy in preeclamptic patients with cardiac failure or oliguria refractory to modest fluid challenges.
    Mesh-Begriff(e) Adult ; Anesthesia, Epidural ; Blood Pressure ; Female ; Gestational Age ; Hemodynamics ; Humans ; Pre-Eclampsia/physiopathology ; Pregnancy ; Pulmonary Edema/physiopathology ; Stroke Volume
    Sprache Englisch
    Erscheinungsdatum 1986-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Effect of enflurane, isoflurane, and halothane on pacing stimulation thresholds in man.

    Zaidan, J R / Curling, P E / Craver, J M

    Pacing and clinical electrophysiology : PACE

    1985  Band 8, Heft 1, Seite(n) 32–34

    Abstract: Volatile anesthetic agents are often used in patients who require temporary epicardial pacing after cardiopulmonary bypass (CPB). However, the effect of anesthetic agents on energy stimulation thresholds is unknown. After CPB, 24 patients under diazepam- ... ...

    Abstract Volatile anesthetic agents are often used in patients who require temporary epicardial pacing after cardiopulmonary bypass (CPB). However, the effect of anesthetic agents on energy stimulation thresholds is unknown. After CPB, 24 patients under diazepam-narcotic-pancuronium anesthesia ventilated with an FIO2 = 1.0 received equipotent concentrations of either enflurane, isoflurane, or halothane. Using temporary epicardial electrodes, energy stimulation thresholds were calculated using the data derived from a pacing systems analyzer. Volatile anesthetics do not change energy stimulation thresholds from those already present under diazepam-narcotic-pancuronium anesthesia.
    Mesh-Begriff(e) Cardiac Pacing, Artificial ; Cardiopulmonary Bypass ; Enflurane/pharmacology ; Halothane/pharmacology ; Heart Conduction System/drug effects ; Humans ; Isoflurane/pharmacology ; Methyl Ethers/pharmacology
    Chemische Substanzen Methyl Ethers ; Enflurane (91I69L5AY5) ; Isoflurane (CYS9AKD70P) ; Halothane (UQT9G45D1P)
    Sprache Englisch
    Erscheinungsdatum 1985-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/j.1540-8159.1985.tb05719.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Mortality and paraplegia after thoracoabdominal aortic aneurysm repair: a risk factor analysis.

    Coselli, J S / LeMaire, S A / Miller, C C / Schmittling, Z C / Köksoy, C / Pagan, J / Curling, P E

    The Annals of thoracic surgery

    2000  Band 69, Heft 2, Seite(n) 409–414

    Abstract: Background: Recent recommendations regarding thoracoabdominal aortic aneurysm (TAAA) management have emphasized individualized treatment based on balancing a patient's calculated risk of rupture with their anticipated risk of postoperative death or ... ...

    Abstract Background: Recent recommendations regarding thoracoabdominal aortic aneurysm (TAAA) management have emphasized individualized treatment based on balancing a patient's calculated risk of rupture with their anticipated risk of postoperative death or paraplegia. The purpose of this study was to enhance this risk-benefit decision by providing contemporary results and determining which preoperative risk factors currently predict mortality and paraplegia after TAAA surgery.
    Methods: Risk factor analyses based on data regarding 1,220 consecutive patients undergoing TAAA repair from 1986 through 1998 were performed using multiple logistic regression with step-wise model selection.
    Results: The 30-day mortality rate was 4.8% (58 of 1,220) and the incidence of paraplegia was 4.6% (56 of 1,206). For elective cases, predictors of operative mortality included renal insufficiency (p = 0.0001), increasing age (p = 0.0005), symptomatic aneurysms (p = 0.0059), and extent II aneurysms (p = 0.0054). Extent II aneurysms (p = 0.0023) and diabetes (p = 0.0402) were predictors of paraplegia.
    Conclusions: These risk models may assist in decisions regarding elective TAAA operations. For patients who are acceptable candidates, contemporary surgical management provides favorable results.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal/mortality ; Aortic Aneurysm, Thoracic/mortality ; Cardiac Surgical Procedures/mortality ; Female ; Humans ; Male ; Middle Aged ; Paraplegia/etiology ; Postoperative Complications ; Risk Assessment ; Risk Factors ; Survival Analysis
    Sprache Englisch
    Erscheinungsdatum 2000-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/s0003-4975(99)01478-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Contamination reduction during central venous catheterization.

    Levy, J H / Nagle, D M / Curling, P E / Waller, J L / Kopel, M / Tobia, V

    Critical care medicine

    1988  Band 16, Heft 2, Seite(n) 165–167

    Abstract: This study examined a simple technique for reducing contamination during catheterization of the internal jugular vein. Sixty patients were assigned randomly to receive either a traditional iodophor skin cleansing or an alcohol cleansing, followed by ... ...

    Abstract This study examined a simple technique for reducing contamination during catheterization of the internal jugular vein. Sixty patients were assigned randomly to receive either a traditional iodophor skin cleansing or an alcohol cleansing, followed by application of an iodophor-impregnated sterile film. In the cleansed with iodophor alone group, 83% of the anesthesiologists' glove tips were contaminated, and 13% of the catheter tips were contaminated. In contrast, in the group in which the sterile film was employed, contamination of gloves and catheters was virtually eliminated.
    Mesh-Begriff(e) 1-Propanol/pharmacology ; Catheterization, Central Venous ; Disinfection/methods ; Disinfection/standards ; Gloves, Surgical ; Humans ; Iodophors ; Occlusive Dressings ; Povidone/analogs & derivatives ; Povidone-Iodine/pharmacology ; Skin/drug effects ; Skin/microbiology ; Staphylococcus epidermidis/isolation & purification ; Sterilization/methods
    Chemische Substanzen Iodophors ; Povidone-Iodine (85H0HZU99M) ; 1-Propanol (96F264O9SV) ; Povidone (FZ989GH94E)
    Sprache Englisch
    Erscheinungsdatum 1988-02
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/00003246-198802000-00014
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  7. Artikel: S100beta correlates with neurologic complications after aortic operation using circulatory arrest.

    LeMaire, S A / Bhama, J K / Schmittling, Z C / Oberwalder, P J / Köksoy, C / Raskin, S A / Curling, P E / Coselli, J S

    The Annals of thoracic surgery

    2001  Band 71, Heft 6, Seite(n) 1913–8; discussion 1918–9

    Abstract: Background: Astrocyte protein S100beta is a potential serum marker for neurologic injury. The goals of this study were to determine whether elevated serum S100beta correlates with neurologic complications in patients requiring hypothermic circulatory ... ...

    Abstract Background: Astrocyte protein S100beta is a potential serum marker for neurologic injury. The goals of this study were to determine whether elevated serum S100beta correlates with neurologic complications in patients requiring hypothermic circulatory arrest (HCA) during thoracic aortic repair, and to determine the impact of retrograde cerebral perfusion (RCP) on S100beta release in this setting.
    Methods: Thirty-nine consecutive patients underwent thoracic aortic repairs during HCA; RCP was used in 25 patients. Serum S100beta was measured preoperatively, after cardiopulmonary bypass, and 24 hours postoperatively.
    Results: Neurologic complications occurred in 3 patients (8%). These patients had higher postbypass S100beta levels (7.17 +/- 1.01 microg/L) than those without neurologic complications (3.63 +/- 2.31 microg/L, p = 0.013). Patients with S100beta levels of 6.0 microg/L or more had a higher incidence of neurologic complications (3 of 7, 43%) compared with those who had levels less than 6.0 microg/L (0 of 30, p = 0.005). Retrograde cerebral perfusion did not affect S100beta release.
    Conclusions: Serum S100beta levels of 6.0 microg/L or higher after HCA correlates with postoperative neurologic complications. Using serum S100beta as a marker for brain injury, RCP does not provide improved cerebral protection over HCA alone.
    Mesh-Begriff(e) Aged ; Aorta, Thoracic/surgery ; Brain/blood supply ; Brain Damage, Chronic/blood ; Brain Damage, Chronic/diagnosis ; Cardiopulmonary Bypass ; Female ; Heart Arrest, Induced ; Humans ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/diagnosis ; Predictive Value of Tests ; Regional Blood Flow/physiology ; S100 Proteins/blood
    Chemische Substanzen S100 Proteins ; S100A1 protein
    Sprache Englisch
    Erscheinungsdatum 2001-06-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/s0003-4975(01)02536-x
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  8. Artikel: Results of coronary surgery after failed elective coronary angioplasty in patients with prior coronary surgery.

    Weintraub, W S / Cohen, C L / Curling, P E / Jones, E L / Craver, J M / Guyton, R / King, S B / Douglas, J S

    Journal of the American College of Cardiology

    1990  Band 16, Heft 6, Seite(n) 1341–1347

    Abstract: The results of coronary artery bypass surgery after failed elective coronary angioplasty in patients who have undergone prior coronary surgery are unknown. Coronary angioplasty may be performed to relieve angina after surgery either to the native ... ...

    Abstract The results of coronary artery bypass surgery after failed elective coronary angioplasty in patients who have undergone prior coronary surgery are unknown. Coronary angioplasty may be performed to relieve angina after surgery either to the native coronary vessels or to grafts. Failure of attempted coronary angioplasty may mandate repeat coronary surgery, often in the setting of acute ischemia. From 1980 to 1989, 1,263 patients with prior coronary bypass surgery underwent angioplasty; of these patients, 46 (3.6%) underwent reoperation for failed angioplasty during the same hospital stay. Of the 46 patients who underwent reoperation, 33 had and 13 did not have acute ischemia. In the group with ischemia, 3 patients (9.1%) died and 14 (42.4%) died or had a Q wave myocardial infarction in the hospital compared with no deaths (p = NS) and no deaths or Q wave myocardial infarction (p = 0.005) in the group without ischemia. At 3 years, the actuarial survival rate was 88 +/- 6% in the group with ischemia, whereas there were no deaths in the group without ischemia (p = NS), and freedom from death or myocardial infarction was 51 +/- 10% in the group with ischemia, versus no events in the group without ischemia (p = 0.006). In most patients with prior coronary bypass surgery, coronary angioplasty was performed without the need for repeat coronary bypass surgery. Should coronary angioplasty fail, reoperation in patients without acute ischemia can be performed with overall patient survival comparable to that of elective reoperative coronary bypass without coronary angioplasty.(ABSTRACT TRUNCATED AT 250 WORDS)
    Mesh-Begriff(e) Aged ; Angioplasty, Balloon, Coronary ; Combined Modality Therapy ; Coronary Artery Bypass/mortality ; Coronary Disease/mortality ; Coronary Disease/physiopathology ; Coronary Disease/therapy ; Electrocardiography ; Emergencies ; Female ; Follow-Up Studies ; Humans ; Length of Stay ; Male ; Middle Aged ; Prospective Studies ; Recurrence ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 1990-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/0735-1097(90)90374-x
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  9. Artikel: Hemodynamic deterioration after coronary angioplasty in the presence of previous left ventricular infarction.

    Murphy, D A / Craver, J M / Jones, E L / King, S B / Curling, P E / Douglas, J S

    The American journal of cardiology

    1984  Band 54, Heft 3, Seite(n) 448–450

    Mesh-Begriff(e) Aged ; Angioplasty, Balloon/adverse effects ; Coronary Artery Bypass ; Coronary Disease/complications ; Coronary Disease/physiopathology ; Coronary Disease/surgery ; Coronary Disease/therapy ; Coronary Vessels/injuries ; Coronary Vessels/pathology ; Female ; Heart Arrest/etiology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/pathology ; Pulmonary Edema/etiology
    Sprache Englisch
    Erscheinungsdatum 1984-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/0002-9149(84)90218-2
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  10. Artikel: Surgical management of acute myocardial ischemia following percutaneous transluminal coronary angioplasty. Role of the intra-aortic balloon pump.

    Murphy, D A / Craver, J M / Jones, E L / Curling, P E / Guyton, R A / King, S B / Gruentzig, A R / Hatcher, C R

    The Journal of thoracic and cardiovascular surgery

    1984  Band 87, Heft 3, Seite(n) 332–339

    Abstract: Acute myocardial ischemia is a serious complication of percutaneous transluminal coronary angioplasty, often requiring emergency myocardial revascularization. Since our initial report of 17 such patients, we have encountered an additional 32 patients ... ...

    Abstract Acute myocardial ischemia is a serious complication of percutaneous transluminal coronary angioplasty, often requiring emergency myocardial revascularization. Since our initial report of 17 such patients, we have encountered an additional 32 patients requiring emergency myocardial revascularization since September, 1981. The indication for emergency myocardial revascularization was ischemic chest pain in all 32 patients. Percutaneous transluminal coronary angioplasty resulted in injury to the right coronary artery in 11 patients, the left anterior descending artery in 19 patients, and the left main artery in two patients. The onset of ischemia was immediate in 26 patients but delayed up to 22 hours in six patients. Chest pain was associated with ST-segment elevation in 21 patients, hypotension in 7 patients, and cardiac arrest in 6 patients. Immediate intra-aortic balloon pumping was instituted in the angioplasty suite in 16 patients. The mean time from onset of ischemia to completed revascularization was 156 minutes with a mean of 1.6 grafts performed per patient. Seventeen patients (53%) had enzyme evidence of myocardial infarction postoperatively, with a significantly higher (p less than 0.01) incidence of myocardial infarction in those patients with preoperative ST elevation (76% versus 9%). In the 21 patients with ST-segment elevation, the incidence of Q wave infarction was 20% (3/15) with balloon pumping and 50% (3/6) without balloon pumping. Complications associated with intra-aortic balloon pumping occurred in one patient (6%). There were no hospital or late deaths with follow-up extending 16 months. The spectrum of injury resulting from percutaneous transluminal coronary angioplasty extends from chest pain alone to severe transmural ischemia with hypotension or cardiac arrest. Presentation may be immediate or delayed. Urgent emergency myocardial revascularization remains the accepted therapy for this complication. Immediate preoperative intra-aortic balloon pumping is a useful adjunct to emergency myocardial revascularization in the group of patients with acute ischemia and ST-segment elevation.
    Mesh-Begriff(e) Acute Disease ; Angioplasty, Balloon/adverse effects ; Coronary Vessels/injuries ; Coronary Vessels/surgery ; Female ; Humans ; Intra-Aortic Balloon Pumping ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Myocardial Infarction/surgery ; Pain/etiology ; Pain/surgery ; Thorax
    Sprache Englisch
    Erscheinungsdatum 1984-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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