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Article ; Online: Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

Nisebita Sahu / Jean-Philippe Stephan / Darlene Dela Cruz / Mark Merchant / Benjamin Haley / Richard Bourgon / Marie Classon / Jeff Settleman

Nature Communications, Vol 7, Iss 1, Pp 1-

2016  Volume 10

Abstract: Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS ... ...

Abstract Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.
Keywords Science ; Q
Language English
Publishing date 2016-08-01T00:00:00Z
Publisher Nature Portfolio
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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