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  1. Artikel ; Online: Psoriasisarthritis : Klinische Herausforderungen und medikamentöses Management.

    Dauth, Stephanie / Klippstein, Maximilian / Köhm, Michaela

    Zeitschrift fur Rheumatologie

    2023  Band 82, Heft 3, Seite(n) 220–232

    Abstract: Psoriatic arthritis (PsA) is a systemic immune-mediated inflammatory disease of the musculoskeletal system, which is accompanied by a chronic and progressive course. It is characterized by different clinical manifestations and can severely impair the ... ...

    Titelübersetzung Psoriatic arthritis : Clinical challenges and pharmaceutical management.
    Abstract Psoriatic arthritis (PsA) is a systemic immune-mediated inflammatory disease of the musculoskeletal system, which is accompanied by a chronic and progressive course. It is characterized by different clinical manifestations and can severely impair the quality of life and function of patients due to the existing heterogeneity of the manifestations. The (early) diagnosis of PsA and individualized therapeutic management in routine clinical practice are difficult due to the enormous clinical variability. In addition to the appearance of arthritis of the peripheral joints, there can be involvement of the axial skeleton, skin psoriasis, nail psoriasis, enthesitis and dactylitis. The clinical appearance, course of the disease, risk factors and pathophysiological mechanisms of PsA have been extensively researched in recent decades. With the associated better understanding of the disease, new treatment options and goals for effective treatment have also been established.
    Mesh-Begriff(e) Humans ; Arthritis, Psoriatic/diagnosis ; Quality of Life ; Psoriasis ; Skin ; Pharmaceutical Preparations
    Chemische Substanzen Pharmaceutical Preparations
    Sprache Deutsch
    Erscheinungsdatum 2023-03-01
    Erscheinungsland Germany
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-023-01326-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Konferenzbeitrag: IL-1 und IL6-inhibierende Therapien reduzieren signifikant die Mortalitätsraten von Patienten mit Hämophagozytischer Lymphohistiozytose als schwere Komplikation von immun-vermittelten Systemerkrankungen

    Dauth, Stephanie / Klippstein, Maximilian / Kunz, Christina / Meier, Florian / Braner, Axel / Behrens, Frank / Köhm, Michaela

    2023  , Seite(n) VS.01

    Veranstaltung/Kongress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2023-08-30
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/23dgrh233
    Datenquelle German Medical Science

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  3. Buch ; Online ; Dissertation / Habilitation: Cathepsin K functions in the mouse central nervous system

    Dauth, Stephanie

    2012  

    Verfasserangabe Stephanie Dauth
    Sprache Englisch
    Umfang Online-Ressource (Online-Ressource)
    Verlag IRC-Library, Information Resource Center der Jacobs University Bremen
    Erscheinungsort Bremen
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Dissertation / Habilitation Bremen, Jacobs Univ., Diss., 2012
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  4. Artikel: Spondyloarthritis

    Holz-Müller, Jana / Dauth, Stephanie / Behrens, Frank / Köhm, Michaela

    Arthritis und Rheuma

    2021  Band 41, Heft 02, Seite(n) 106–122

    Abstract: Der Begriff Spondyloarthritis umfasst mehrere Krankheitsbilder, die sich in der Pathophysiologie und im klinischen Erscheinungsbild ähneln. Zu der Gruppe der Spondyloarthritiden werden die axiale Spondyloarthritis, die Psoriasisarthritis, die reaktive ... ...

    Abstract Der Begriff Spondyloarthritis umfasst mehrere Krankheitsbilder, die sich in der Pathophysiologie und im klinischen Erscheinungsbild ähneln. Zu der Gruppe der Spondyloarthritiden werden die axiale Spondyloarthritis, die Psoriasisarthritis, die reaktive Arthritis, die chronisch entzündliche Darmerkrankung (CED)-assoziierte Spondyloarthritis und die undifferenzierte Spondyloarthritis gezählt. Die Auswahl von geeigneten Therapiestrategien mit hoher klinischer Effektstärke basiert stärker auf der Charakterisierung des klinischen Phänotyps und des Manifestationstyps als auf der indikationsbasierten Zuordnung. Durch die Heterogenität der Erkrankung und durch das Fehlen kontrollierter klinischer Studien, die als Endpunkt die Effektivität auf verschiedene Manifestationsformen vorsieht, ist die Evidenzlage für verschiedene Therapieprinzipien bezogen auf das Manifestationslevel niedrig. Dies beschränkt den In-Label-Einsatz verschiedener Wirkprinzipien. Hier besteht ein hoher Bedarf für die Potenzierung von Evidenz, damit effektive Therapien individualisiert im Patientenkollektiv eingesetzt werden können.

    The term “spondyloarthritis” encompasses several clinical indications that are similar in pathophysiology and clinical appearance. Spondyloarthritis includes axial spondyloarthritis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease (IBD)-associated spondyloarthritis and undifferentiated spondyloarthritis. The selection of suitable therapy strategies with a high clinical effect size is based more on the characterization of the clinical phenotype and the manifestation type than on the indication-based assignment. Due to the heterogeneity of the diseases and the lack of controlled clinical studies, which envisage the effectiveness on various forms of manifestation as an endpoint, the evidence base for various therapeutic principles in relation to the level of manifestation is low. This limits the in-label use of various active principles. There is a high need here for the potentiation of evidence so that effective therapies can be used in an individualized way in this special patient cohort.
    Schlagwörter Axiale Spondyloarthritis ; Psoriasisarthritis ; reaktive Arthritis ; Therapieempfehlungen ; Klassifikation ; Axial spondyloarthritis ; psoriatic arthritis ; reactive arthritis ; treatment recommendations ; classification
    Sprache Deutsch
    Erscheinungsdatum 2021-04-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-1352-9692
    Datenquelle Thieme Verlag

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  5. Artikel: Spondyloarthritis

    Holz-Müller, Jana / Dauth, Stephanie / Behrens, Frank / Köhm, Michaela

    Arthritis + Rheuma

    2021  Band 41, Heft 2, Seite(n) 106

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 605764-0
    ISSN 0176-5167
    Datenquelle Current Contents Medizin

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  6. Buch ; Online ; Dissertation / Habilitation: Cathepsin K functions in the mouse central nervous system

    Dauth, Stephanie [Verfasser]

    2012  

    Verfasserangabe Stephanie Dauth
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Englisch
    Verlag IRC-Library, Information Resource Center der Jacobs University Bremen
    Erscheinungsort Bremen
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  7. Artikel ; Online: Impact of different classes of immune-modulating treatments on B cell-related and T cell-related immune response before and after COVID-19 booster vaccination in patients with immune-mediated diseases and primary immunodeficiency: a cohort study.

    Koehm, Michaela / Klippstein, Maximilian / Dauth, Stephanie / Hallmann, Konstantin / Kohmer, Niko / Burkhardt, Harald / Ciesek, Sandra / Geisslinger, Gerd / Rabenau, Holger F / Behrens, Frank

    RMD open

    2023  Band 9, Heft 3

    Abstract: Objectives: To evaluate the potential of immunosuppressed patients to mount B-cell and T-cell responses to COVID-19 booster vaccination (third vaccination).: Methods: Patients with primary immunodeficiency (PID), immune-mediated inflammatory diseases ...

    Abstract Objectives: To evaluate the potential of immunosuppressed patients to mount B-cell and T-cell responses to COVID-19 booster vaccination (third vaccination).
    Methods: Patients with primary immunodeficiency (PID), immune-mediated inflammatory diseases (IMIDs) on CD20-depleting treatment with rituximab (RTX), or IMIDs treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or biological disease-modifying antirheumatic drug (bDMARDs) were included and assessed before (baseline visit (BL)) and 2, 4 and 8 weeks after COVID-19 booster vaccination. Serum B-cell responses were assessed by antibody levels against SARS-CoV-2 spike protein (anti-spike IgG antibody (S-AB)) and a surrogate virus neutralisation test (sVNT). T-cell responses were assessed by an interferon gamma release assay (IGRA).
    Results: Fifty patients with PID (n=6), treated with RTX therapy (n=13), or treated with csDMARDs/bDMARDs (n=31) were included. At BL, anti-S-AB titres in PID and csDMARD/bDMARD-treated patients were low (although significantly higher than RTX patients); measures of B-cell-mediated response increased significantly after booster vaccination. In the RTX cohort, low BL anti-S-AB and sVNT values did not improve after booster vaccination, but patients had significantly elevated IGRA responses post booster vaccination compared with the other groups. csDMARD/bDMARD-treated patients showed the highest BL values in all three assays with greater increases in all parameters after booster vaccination compared with patients with PID.
    Conclusion: Patients with IMID on therapeutic B-cell depletion have low anti-S-AB and sVNT values before and after booster vaccination but show significantly higher levels of IGRA compared with other immunosuppressed patients, suggesting an underlying mechanism attempting to compensate compromised humoral immunity by upregulating T-cell responsiveness. PID appears to have a stronger impact on antiviral immune response than csDMARD/bDMARD treatment.
    Mesh-Begriff(e) Humans ; Cohort Studies ; Immunomodulating Agents ; COVID-19/prevention & control ; SARS-CoV-2 ; T-Lymphocytes ; Antirheumatic Agents/therapeutic use
    Chemische Substanzen spike protein, SARS-CoV-2 ; Immunomodulating Agents ; Antirheumatic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-08-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Aufgabenteilung im hausärztlichen Praxisteam bei der Durchführung von Versorgungsstudien. How Do Family Practice Teams Divide up Health Services Research Responsibilities?

    Mergenthal, Karola / Schulz-Rothe, Sylvia / Siebenhofer, Andrea / Gerlach, Ferdinand M. / Dauth, Stephanie / Petersen, Juliana J.

    Zeitschrift für Allgemeinmedizin

    2021  Band 97, Heft 6, Seite(n) 281

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 522031-2
    ISSN 1433-6251 ; 0937-6801
    Datenquelle Current Contents Medizin

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  9. Artikel ; Online: Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

    Yu, D.M.T. / Dauth, Stephanie / Margineanu, M.B. / Snetkova, V. / Rehders, M. / Jordans, S. / Brix, K.

    2022  

    Abstract: The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk-/-) mice have learning and memory impairments. Alterations in cathepsin expression are known to result in ... ...

    Abstract The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk-/-) mice have learning and memory impairments. Alterations in cathepsin expression are known to result in compensatory changes in levels of related cathepsins. To gain insight into the therapeutic usefulness of cathepsin inhibitors in aging individuals with osteoporosis or neurodegenerative diseases, we studied for variations in cathepsin expression and activity in aged (18-20 months) versus young (5-7 months) wild-type (WT) and cathepsin-deficient mice brains. There were age-dependent increases in cathepsin B, D, and L and cystatin C protein levels in various brain regions, mainly of WT and Ctsk-/- mice. This corresponded with changes in activity levels of cathepsins B and L, but not cathepsin D. In contrast, very little age-dependent variation was observed in cathepsin-B-and cathepsin-L-deficient mouse brain, especially at the protein level. The observed alterations in cathepsin protein amounts and activity are likely contributing to changes in important aging-related processes such as autophagy. In addition, the results provide insight into the potential impact of cathepsin inhibitor therapy in aged individuals, as well as in long-term use of cathepsin inhibitor therapy.

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    Schlagwörter Aging disorders ; Aspartic proteases ; Brain ; Cystatin C ; Cysteine peptidases ; Lysosomes ; Protease inhibitor therapy
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Konferenzbeitrag: Fluorescence-optical imaging technique discriminates signs of early joint inflammation in patients suspect of Rheumatoid Arthritis in the PANORA trial

    Köhm, Michaela / Ohrndorf, Sarah / Glimm, Anne-Marie / Dauth, Stephanie / Henkemeier, Ulf / Rossmanith, Tanja / Burkhardt, Harald Louis / Behrens, Frank

    2021  , Seite(n) DI.11

    Veranstaltung/Kongress Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); sine loco [digital]; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2021
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2021-09-14
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/21dgrh029
    Datenquelle German Medical Science

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