Artikel ; Online: Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine.
NPJ vaccines
2024 Band 9, Heft 1, Seite(n) 12
Abstract: Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced candidate vaccines, RTS,S and R21, are subunit (SU) vaccines that target a ...
| Abstract | Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced candidate vaccines, RTS,S and R21, are subunit (SU) vaccines that target a single Plasmodium falciparum (Pf) pre-erythrocytic (PE) sporozoite (spz) surface protein known as circumsporozoite (CS). These vaccines induce humoral immunity but fail to elicit CD8 + T-cell responses sufficient for long-term protection. In contrast, whole-organism (WO) vaccines, such as Radiation Attenuated Sporozoites (RAS), achieved sterile protection but require a series of intravenous doses administered in multiple clinic visits. Moreover, these WO vaccines must be produced in mosquitos, a burdensome process that severely limits their availability. To reduce reliance on WO while maintaining protection via both antibodies and Trm responses, we have developed an accelerated vaccination regimen that combines two distinct agents in a prime-and-trap strategy. The priming dose is a single dose of self-replicating RNA encoding the full-length P. yoelii CS protein, delivered via an advanced cationic nanocarrier (LION |
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| Sprache | Englisch |
| Erscheinungsdatum | 2024-01-10 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ISSN | 2059-0105 |
| ISSN (online) | 2059-0105 |
| DOI | 10.1038/s41541-023-00799-4 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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