LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Noncoding RNAs as circulating biomarkers in osteosarcoma patients.

    Botti, Gerardo / Giordano, Antonio / Feroce, Florinda / De Chiara, Anna Rosaria / Cantile, Monica

    Journal of cellular physiology

    2019  Volume 234, Issue 11, Page(s) 19249–19255

    Abstract: Noncoding RNAs (ncRNAs) identify a large family of RNAs that do not encode proteins and represent an important group of tumor biomarkers, directly involved in the process of tumor pathogenesis and progression. Many of them have also been identified in ... ...

    Abstract Noncoding RNAs (ncRNAs) identify a large family of RNAs that do not encode proteins and represent an important group of tumor biomarkers, directly involved in the process of tumor pathogenesis and progression. Many of them have also been identified in biological fluids of patients with cancer, especially blood, suggesting their role as an emerging class of circulating biomarkers. Many ncRNAs, both miRNAs and lncRNAs, are deregulated in sarcoma tissues, with the most consistent data in osteosarcomas. In patients with osteosarcoma, the role of ncRNAs as circulating biomarkers is taking enormous value, above all for their ability to vary expression levels during disease progression and in response to therapy. In this mini-review, we summarize the main studies supporting the role of circulating ncRNAs in monitoring disease status in patients with osteosarcoma.
    MeSH term(s) Biomarkers, Tumor/blood ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MicroRNAs/blood ; MicroRNAs/genetics ; Osteosarcoma/blood ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; RNA, Long Noncoding/blood ; RNA, Long Noncoding/genetics ; RNA, Untranslated/blood ; RNA, Untranslated/genetics
    Chemical Substances Biomarkers, Tumor ; MicroRNAs ; RNA, Long Noncoding ; RNA, Untranslated
    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.28744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The Impact of O6-Methylguanine-DNA Methyltransferase (

    Cannella, Lucia / Della Monica, Rosa / Marretta, Antonella Lucia / Iervolino, Domenico / Vincenzi, Bruno / De Chiara, Anna Rosaria / Clemente, Ottavia / Buonaiuto, Michela / Barretta, Maria Luisa / Di Mauro, Annabella / Di Marzo, Massimiliano / Guida, Michele / Badalamenti, Giuseppe / Chiariotti, Lorenzo / Tafuto, Salvatore

    Cells

    2023  Volume 12, Issue 12

    Abstract: Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA ... ...

    Abstract Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA methyltransferase (
    MeSH term(s) Humans ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/pathology ; Dacarbazine/therapeutic use ; DNA ; DNA Methylation/genetics ; DNA Modification Methylases/genetics ; DNA Modification Methylases/therapeutic use ; DNA Repair Enzymes/genetics ; Leiomyosarcoma/drug therapy ; Leiomyosarcoma/genetics ; Methyltransferases/genetics ; Retrospective Studies ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Tumor Suppressor Proteins/genetics ; Middle Aged
    Chemical Substances Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI) ; DNA (9007-49-2) ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-) ; Methyltransferases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; O-(6)-methylguanine (9B710FV2AE) ; Temozolomide (YF1K15M17Y) ; Tumor Suppressor Proteins
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12121635
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Primary giant clear cell sarcoma (soft tissue malignant melanoma) of the sternum.

    Rocco, Gaetano / de Chiara, Anna Rosaria / Fazioli, Flavio / Scognamiglio, Francesco / La Rocca, Antonello / Apice, Gaetano / Riva, Carla

    The Annals of thoracic surgery

    2009  Volume 87, Issue 6, Page(s) 1927–1928

    Abstract: One case of a primary clear cell sarcoma of the sternum (also called soft tissue melanoma) is reported. This neoplasm represents a rare occurrence, and as a rule, differential diagnosis with melanoma often requires detailed immunohistochemistry and ... ...

    Abstract One case of a primary clear cell sarcoma of the sternum (also called soft tissue melanoma) is reported. This neoplasm represents a rare occurrence, and as a rule, differential diagnosis with melanoma often requires detailed immunohistochemistry and cytogenetic analysis (ie, rearrangement of EWS gene localized on 22q12 chromosome). Because wide resection is recommended, chest wall reconstruction may pose challenging technical issues. In our patient, we elected not to proceed to clavicular stabilization. Nevertheless, acceptable shoulder girdle mobility was observed after surgery.
    MeSH term(s) Bone Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Sarcoma, Clear Cell/surgery ; Sternum
    Language English
    Publishing date 2009-06
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2008.10.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top