Artikel ; Online: Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology.
2023 Band 102, Heft 1, Seite(n) e207807
Abstract: Background and objectives: Both short and long sleep duration were previously associated with incident dementia, but underlying mechanisms remain unclear. We evaluated how self-reported sleep duration and its change over time associate with (A)myloid, ( ... ...
Abstract | Background and objectives: Both short and long sleep duration were previously associated with incident dementia, but underlying mechanisms remain unclear. We evaluated how self-reported sleep duration and its change over time associate with (A)myloid, (T)au, (N)eurodegeneration, and (V)ascular neuroimaging markers of Alzheimer disease. Methods: Two Framingham Heart Study overlapping samples were studied: participants who underwent Results: The tested cohort was composed of 271 participants (age 53.6 ± 8.0 years; 51% male) in the PET imaging sample and 2,165 participants (age 61.3 ± 11.1 years; 45% male) in the MRI sample. No fully adjusted association was observed between cross-sectional sleep duration and neuroimaging metrics. In fully adjusted models compared with consistently sleeping 7-8 hours, groups transitioning to a longer sleep duration category over time had higher FW fraction (short to average β [SE] 0.0062 [0.0024], Discussion: Longer self-reported sleep duration over time was associated with neuroimaging biomarkers of cerebrovascular pathology as evidenced by higher WMH burden and FW fraction. A longer sleep duration extending over time may be an early change in the neurodegenerative trajectory. |
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Mesh-Begriff(e) | Male ; Humans ; Middle Aged ; Aged ; Female ; Sleep Duration ; Cross-Sectional Studies ; Amyloidogenic Proteins ; Neuroimaging ; Biomarkers |
Chemische Substanzen | Amyloidogenic Proteins ; Biomarkers |
Sprache | Englisch |
Erscheinungsdatum | 2023-12-13 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 207147-2 |
ISSN | 1526-632X ; 0028-3878 |
ISSN (online) | 1526-632X |
ISSN | 0028-3878 |
DOI | 10.1212/WNL.0000000000207807 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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