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  1. Buch ; Online ; Dissertation / Habilitation: Elektrophysiologische Charakterisierung neuronaler spannungsabhängiger Calciumströme des Locus coeruleus in zwei experimentellen Parkinson-Modellen der Maus

    Griesbach, Markus [Verfasser] / Decher, Niels [Akademischer Betreuer]

    2023  

    Verfasserangabe Markus Griesbach ; Betreuer: Niels Decher
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Philipps-Universität Marburg
    Erscheinungsort Marburg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  2. Buch ; Online ; Dissertation / Habilitation: Elektrophysiologische Charakterisierung der Locus coeruleus Neuronen von Parkin­-Knockout Mäusen mit Hilfe der Patch­-Clamp­-Technik

    Müller, Ann-Katrin [Verfasser] / Decher, Niels [Akademischer Betreuer]

    2022  

    Verfasserangabe Ann-Katrin Müller ; Betreuer: Niels Decher
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Philipps-Universität Marburg
    Erscheinungsort Marburg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  3. Artikel ; Online: Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice.

    Labbaf, Afsaneh / Dellin, Maurice / Komadowski, Marlene / Chetkovich, Dane M / Decher, Niels / Pape, Hans-Chrisitian / Seebohm, Guiscard / Budde, Thomas / Zobeiri, Mehrnoush

    Biological chemistry

    2023  Band 404, Heft 4, Seite(n) 291–302

    Abstract: Tonic current through hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels is influencing neuronal firing properties and channel function is strongly influenced by the brain-specific auxiliary subunit tetratricopeptide repeat- ... ...

    Abstract Tonic current through hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels is influencing neuronal firing properties and channel function is strongly influenced by the brain-specific auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b). Since Kv1.2 channels and TRIP8b were also suggested to interact, we assessed brain Kv1.2 mRNA and protein expression as well as the reduction of K
    Mesh-Begriff(e) Mice ; Animals ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Neurons/metabolism ; Hippocampus/metabolism ; Brain/metabolism ; Oocytes
    Chemische Substanzen Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
    Sprache Englisch
    Erscheinungsdatum 2023-03-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2023-0116
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Online ; Dissertation / Habilitation: Aufklärung des molekularen krankheitsauslösenden Mechanismus der progressiven kardialen Reizleitungsstörung durch die Mutation G88R im Tandem-Poren-Kanal TASK-4

    Leonhardt, Julia [Verfasser] / Decher, Niels [Akademischer Betreuer]

    2021  

    Verfasserangabe Julia Leonhardt ; Betreuer: Niels Decher
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Philipps-Universität Marburg
    Erscheinungsort Marburg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  5. Artikel ; Online: Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells.

    Zhang, Yuequ / Shaabani, Shabnam / Vowinkel, Kirsty / Trombetta-Lima, Marina / Sabogal-Guáqueta, Angélica María / Chen, Tingting / Hoekstra, Jan / Lembeck, Jan / Schmidt, Martina / Decher, Niels / Dömling, Alexander / Dolga, Amalia M

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Band 171, Seite(n) 116163

    Abstract: Small conductance calcium-activated potassium (SK) channel activity has been proposed to play a role in the pathology of several neurological diseases. Besides regulating plasma membrane excitability, SK channel activation provides neuroprotection ... ...

    Abstract Small conductance calcium-activated potassium (SK) channel activity has been proposed to play a role in the pathology of several neurological diseases. Besides regulating plasma membrane excitability, SK channel activation provides neuroprotection against ferroptotic cell death by reducing mitochondrial Ca
    Mesh-Begriff(e) Mice ; Animals ; Small-Conductance Calcium-Activated Potassium Channels ; Reactive Oxygen Species/metabolism ; Ferroptosis ; Neurons/metabolism ; Mitochondria/metabolism
    Chemische Substanzen Small-Conductance Calcium-Activated Potassium Channels ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116163
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Molecular Pharmacology of K

    Decher, Niels / Rinné, Susanne / Bedoya, Mauricio / Gonzalez, Wendy / Kiper, Aytug K

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2021  Band 55, Heft S3, Seite(n) 87–107

    Abstract: Potassium channels of the tandem of two-pore-domain ( ... ...

    Abstract Potassium channels of the tandem of two-pore-domain (K
    Mesh-Begriff(e) Action Potentials/drug effects ; Action Potentials/physiology ; Binding Sites ; Cardiac Conduction System Disease/drug therapy ; Cardiac Conduction System Disease/genetics ; Cardiac Conduction System Disease/metabolism ; Cardiac Conduction System Disease/pathology ; Gene Expression ; Humans ; Ion Channel Gating/drug effects ; Ion Transport ; Ligands ; Membrane Transport Modulators/chemistry ; Membrane Transport Modulators/classification ; Membrane Transport Modulators/pharmacology ; Migraine Disorders/drug therapy ; Migraine Disorders/genetics ; Migraine Disorders/metabolism ; Migraine Disorders/pathology ; Molecular Dynamics Simulation ; Organ Specificity ; Potassium/metabolism ; Potassium Channels, Tandem Pore Domain/classification ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Protein Binding ; Protein Isoforms/classification ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Structure, Secondary
    Chemische Substanzen Ligands ; Membrane Transport Modulators ; Potassium Channels, Tandem Pore Domain ; Protein Isoforms ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2021-03-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.33594/000000339
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch ; Online ; Dissertation / Habilitation: Prämotorisches Modell der Parkinson-Krankheit: Elektrophysiologische Charakterisierung von Locus coeruleus Neuronen nach α-Synuklein-Überexpression im Mausmodell

    Paiba, Annette [Verfasser] / Decher, Niels [Akademischer Betreuer]

    2020  

    Verfasserangabe Annette Paiba ; Betreuer: Niels Decher
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Philipps-Universität Marburg
    Erscheinungsort Marburg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  8. Artikel: Common Structural Pattern for Flecainide Binding in Atrial-Selective K

    Mazola, Yuliet / Márquez Montesinos, José C E / Ramírez, David / Zúñiga, Leandro / Decher, Niels / Ravens, Ursula / Yarov-Yarovoy, Vladimir / González, Wendy

    Pharmaceutics

    2022  Band 14, Heft 7

    Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels. However, AADs have been limited by proarrhythmic effects, non-cardiovascular toxicities ... ...

    Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels. However, AADs have been limited by proarrhythmic effects, non-cardiovascular toxicities as well as often modest antiarrhythmic efficacy. Theoretical models showed that a combined blockade of Na
    Sprache Englisch
    Erscheinungsdatum 2022-06-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071356
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5.

    Rinné, Susanne / Kiper, Aytug K / Jacob, Ralf / Ortiz-Bonnin, Beatriz / Schindler, Roland F R / Fischer, Sabine / Komadowski, Marlene / De Martino, Emilia / Schäfer, Martin K-H / Cornelius, Tamina / Fabritz, Larissa / Helker, Christian S M / Brand, Thomas / Decher, Niels

    iScience

    2024  Band 27, Heft 5, Seite(n) 109696

    Abstract: Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the ... ...

    Abstract Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109696
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Mechanosensitive TREK-1 two-pore-domain potassium (K

    Wiedmann, Felix / Rinné, Susanne / Donner, Birgit / Decher, Niels / Katus, Hugo A / Schmidt, Constanze

    Progress in biophysics and molecular biology

    2020  Band 159, Seite(n) 126–135

    Abstract: TWIK-related ... ...

    Abstract TWIK-related K
    Mesh-Begriff(e) Animals ; Anti-Arrhythmia Agents/metabolism ; Anti-Arrhythmia Agents/pharmacology ; Arrhythmias, Cardiac/metabolism ; Biomechanical Phenomena/physiology ; Cardiomegaly/metabolism ; Cardiovascular System/metabolism ; Drug Development ; Heart Failure/metabolism ; Humans ; Lipid Bilayers/metabolism ; Myocytes, Cardiac/metabolism ; Potassium/metabolism ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Xenopus laevis
    Chemische Substanzen Anti-Arrhythmia Agents ; Lipid Bilayers ; Potassium Channels, Tandem Pore Domain ; potassium channel protein TREK-1 ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2020-06-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2020.05.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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