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  1. Artikel ; Online: Extended-duration thromboprophylaxis for abdominopelvic surgery: Development and evaluation of a risk-stratified patient decision aid to facilitate shared decision making.

    Ivankovic, Victoria / McAlpine, Kristen / Delic, Edita / Carrier, Marc / Stacey, Dawn / Auer, Rebecca C

    Research and practice in thrombosis and haemostasis

    2022  Band 6, Heft 8, Seite(n) e12831

    Abstract: Background: Extended-duration thromboprophylaxis is used to decrease risk of venous thromboembolism (VTE) after surgery but may increase the risk of bleeding. The decision to complete a course of extended-duration thromboprophylaxis can be challenging.!# ...

    Abstract Background: Extended-duration thromboprophylaxis is used to decrease risk of venous thromboembolism (VTE) after surgery but may increase the risk of bleeding. The decision to complete a course of extended-duration thromboprophylaxis can be challenging.
    Objective: The objective of this study was to develop an acceptable patient decision aid (PtDA) to facilitate shared decision making for the use of extended-duration thromboprophylaxis following major abdominal surgery.
    Methods: An evidence-based, risk-stratified PtDA was created. The evidence on benefits and harms of a 28-day postoperative course of low-molecular-weight heparin (LMWH) versus in-hospital prophylaxis only were synthesized. Outcomes included minor bleeding, major bleeding, clinically significant VTE, and fatal VTE. Risks were calculated and reported by Caprini score. Alpha testing of the PtDA draft with various stakeholders was performed using a 10-question survey to assess acceptability of the PtDA with patients, thrombosis experts, and surgeons. The primary outcome was the acceptability of the PtDA.
    Results: Acceptability testing was performed with 11 patients, 11 thrombosis experts, and 11 surgeons. Most responders felt the language on the PtDA was easy to follow (28/33, 85%), and that the information was well balanced between management options (9/11 [82%] patients; 17/21 [80%] clinicians). Most patients (9/11, 82%) and clinicians (18/22, 82%) believed it would be a useful clinical tool, and were satisfied with the overall quality of the PtDA (27/33, 82%).
    Conclusions: A risk-stratified, evidence-based PtDA was created to facilitate shared decision making for the use of extended-duration LMWH following major abdominal surgery. This clinical tool was acceptable with patients and physicians and is available at https://decisionaid.ohri.ca/decaids.html.
    Sprache Englisch
    Erscheinungsdatum 2022-11-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12831
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Self-sampling of blood using a topper and pediatric tubes; a prospective feasibility study for PSA analysis using 120 prostate cancer patients.

    van den Brink, Nicas / Even, Rixt / Delic, Enver / van Hellenberg Hubar-Fisher, Sarah / van Rossum, Huub H

    Clinical chemistry and laboratory medicine

    2023  Band 61, Heft 12, Seite(n) 2159–2166

    Abstract: Objectives: Self-collection of blood for diagnostic purposes by blood collection assist devices (BCAD) has gained a lot of momentum. Nonetheless, there are a lack of studies demonstrating the feasibility and reliability of self-collecting capillary ... ...

    Abstract Objectives: Self-collection of blood for diagnostic purposes by blood collection assist devices (BCAD) has gained a lot of momentum. Nonetheless, there are a lack of studies demonstrating the feasibility and reliability of self-collecting capillary blood for routine (immuno)chemistry testing. In this study we describe the topper technology together with pediatric tubes to enable self-collection of blood and investigated its feasibility for PSA testing by prostate cancer patients.
    Methods: A total of 120 prostate cancer patients for which a routine follow-up PSA test was requested, were included in this study. Patients received instruction materials and the blood-collection device consisting of a topper, pediatric tube and base-part, and performed the blood collection procedure themselves. Afterwards a questionnaire was filled-in. Finally, PSA was measured on a Roche Cobas Pro.
    Results: The overall self-sampling success rate was 86.7 %. Furthermore, when specified per age category, a 94.7 % success rate for patients under 70 years and a 25 % success rate for patients of 80 years and older was observed. Venous and self-collected PSA were highly comparable when analyzed by Passing-Bablok regression with a slope of 0.99 and intercept of 0.00011, Spearmans correlation coefficient (0.998) and average self-collected PSA recovery of 99.8 %.
    Conclusions: Evidence is presented that self-collected capillary blood by topper and pediatric tube from the finger is feasible, particularly for patients under 70 years. Furthermore, capillary blood self-sampling did not compromise any of the PSA test results. Future validation in a real-world setting, without supervision and including sample stability and logistics, is required.
    Mesh-Begriff(e) Male ; Humans ; Child ; Aged ; Prostate-Specific Antigen ; Feasibility Studies ; Prospective Studies ; Reproducibility of Results ; Prostatic Neoplasms/diagnosis
    Chemische Substanzen Prostate-Specific Antigen (EC 3.4.21.77)
    Sprache Englisch
    Erscheinungsdatum 2023-06-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0272
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Adjuvant melatonin for the prevention of recurrence and mortality following lung cancer resection (AMPLCaRe): A randomized placebo controlled clinical trial.

    Seely, Dugald / Legacy, Mark / Auer, Rebecca C / Fazekas, Anna / Delic, Edita / Anstee, Caitlin / Angka, Leonard / Kennedy, Michael A / Tai, Lee-Hwa / Zhang, Tinghua / Maziak, Donna E / Shamji, Farid M / Sundaresan, R Sudhir / Gilbert, Sebastien / Villeneuve, P James / Ashrafi, Ahmad S / Inculet, Richard / Yasufuku, Kazuhiro / Waddell, Thomas K /
    Finley, Christian / Shargall, Yaron / Plourde, Madelaine / Fergusson, Dean A / Ramsay, Tim / Seely, Andrew J E

    EClinicalMedicine

    2021  Band 33, Seite(n) 100763

    Abstract: Background: Despite curative intent resection in patients with non-small cell lung cancer (NSCLC), recurrence leading to mortality remains too common. Melatonin has shown promise for the treatment of patients with lung cancer; however, its effect ... ...

    Abstract Background: Despite curative intent resection in patients with non-small cell lung cancer (NSCLC), recurrence leading to mortality remains too common. Melatonin has shown promise for the treatment of patients with lung cancer; however, its effect following cancer resection has not been studied. We evaluated if melatonin taken after complete resection reduces lung cancer recurrence and mortality, or impacts quality of life (QOL), symptomatology or immune function.
    Methods: Participants received melatonin (20 mg) or placebo nightly for one year following surgical resection of primary NSCLC. The primary outcome was two-year disease-free survival (DFS). Secondary outcomes included five-year DFS, adverse events, QOL, fatigue, sleep, depression, anxiety, pain, and biomarkers assessing for immune function/inflammation. This study is registered at https://clinicaltrials.gov NCT00668707.
    Findings: 709 patients across eight centres were randomized to melatonin (
    Interpretation: Adjuvant melatonin following resection of NSCLC does not affect DFS for patients with resected early stage NSCLC, yet may increase DFS in patients with late stage disease. Further study is needed to confirm this positive result. No beneficial effects were seen in QOL, symptoms, or immune function.
    Funding: This study was funded by the Lotte and John Hecht Memorial Foundation and the Gateway for Cancer Research Foundation.
    Sprache Englisch
    Erscheinungsdatum 2021-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2021.100763
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: 2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

    Johnson, G / Vergis, A / Unger, B / Park, J / Gillman, L / Hickey, K / Pace, D / Azin, A / Guidolin, K / Lam-Tin-Cheung, K / Chadi, S / Quereshy, F / Catton, J / Rubin, B / Bell, J / Marangos, J / Heesters, A / Stuart-McEwan, T / Shariff, F /
    Wright, F / Ahmed, N / Nadler, A / Hallet, J / Gentles, J / Chen, L / Hwang, H / Parapini, M / Hirpara, D / Sidhu, R / Scott, T / Karimuddin, A / Guo, R / Nguyen, A / Osborn, J / Wiseman, S / Nabata, K / Ertel, E / Lenet, T / Baker, L / Park, L / Vered, M / Zahrai, A / Shorr, R / Davis, A / McIsaac, D / Tinmouth, A / Fergusson, D / Martel, G / Rummel, S / Stefic-Cubic, M / Stewart, M / Melck, A / McKechnie, T / Anpalagan, T / Ichhpuniani, S / Lee, Y / Ramji, K / Eskicioglu, C / Zhu, A / Deng, S / Greene, B / Tsang, M / Palter, V / Jayaraman, S / Mann, A / Tittley, J / Cadeddu, M / Nguyen, M / Madani, A / Pasternak, J / Hong, D / Qu, L / Istl, A / Tang, E / Gray, D / Zuckerman, J / Coburn, N / Callum, J / McLeod, R / Pearsall, E / Lin, Y / Turgeon, A / Mahar, A / Kammili, A / Kriviraltcheva-Kaneva, P / Lee, L / Cools-Lartigue, J / Ferri, L / Mueller, C / Haas, B / Tillman, B / Guttman, M / Chesney, T / Zuk, V / Hsu, A / Chan, W / Vasdev, R / D'Souza, K / Huynh, C / Ling, L Cadili J / Warburton, R / Hameed, M / Glass, L / Williamson, H / Murphy, P / Leslie, K / Hawel, J / Kerr, L / Zablotny, S / Roldan, H / He, W / Jiang, X / Zheng, B / Fiore, J / Feldman, L / Fried, G / Valanci, S / Balvardi, S / Cipolla, J / Kaneva, P / Demyttenaere, S / Boutros, M / Alhashemi, M / Miles, A / Purich, K / Verhoeff, K / Shapiro, J / Bigam, D / Kung, J / Fecso, A / Mosko, J / Skubleny, D / Hamilton, P / Ghosh, S / Widder, S / Schiller, D / Do, U / El Kefraoui, C / Pook, M / Barone, N / Montgomery, H / Nguyen-Powanda, P / Rajabiyazdi, F / Elhaj, H / Lapointe-Gagner, M / Olleik, G / Antoun, A / Safa, N / Di Lena, E / Meterissian, S / Meguerditchian, A / Lee, F / Baldini, G / Serrano Aybar, P E / Parpia, S / Ruo, L / Tywonek, K / Lee, S / O'Neill, C / Faisal, N / Alfayyadh, A / Gundayao, M / Meyers, B M / Habashi, R / Kruse, C / Levin, M / Aldrich, K / Grantcharov, T / Langerman, A / Forbes, H / Anantha, R / Fawcett, V / Hetherington, A / Pravong, V / Gervais, M / Rakovich, G / Selvam, R / Hu, R / Musselman, R / Raiche, I / Moloo, H / Liu, R / Elnahas, A / Alkhamesi, N / Alnumay, A / Schlachta, C / Walser, E / Zhang, C / Cristancho, S / Ott, M / Lee, A / Niu, B / Balaa, F / Gawad, N / Ren, K / Qiu, Y / Hamann, K / How, N / Leveille, C / Davidson, A / Eqbal, A / Sardiwalla, Y / Korostensky, M / Lee, E / Yang, I / Muaddi, H / Stukel, T / de Mestral, C / Nathens, A / Karanicolas, P / Frigault, J / Lemieux, S / Breton, D / Bouchard, P / Bouchard, A / Grégoire, R / Letarte, F / Bouchard, G / Drolet, S / Avoine, S / Gagné, J / Thibault, C / Jutras Bouthillette, N / Gosselin, M / Rosenzveig, A / Stuleanu, T / Jarrar, A / Kolozsvari, N / Skelhorne-Gross, G / Nenshi, R / Jerath, A / Gomez, D / Singh, K / Amir, T / Liu, E / Farquharson, S / Mao, R / Lan, L / Yan, J / Allard-Coutu, A / Mierzwa, A / Tin, R / Brisebois, R / Bradley, N / Wigen, R / Hartford, L / Van Koughnett, J / Vogt, K / Hilsden, R / Parry, N / Allen, L / Raskin, R / Jones, J / Neumann, K / Dwyer, C / Strickland, M / O'Dochartaigh, D / Lobay, K / Kabaroff, A / Chang, E / Sun, W / Beck, J / Davidson, J / Jones, S / Van Hooren, T / Schmitz, E / El Hafid, M / Dang, J / Mocanu, V / Lutzak, G / Sultanian, R / Wong, C / Karmali, S / Petrera, M / Pickell, M / Auer, R / Patro, N / Li, B / Wilson, H / Jogiat, U / Switzer, N / Li, C / Al Hinai, A / Cieply, A / Hawes, H / Joos, E / Saleh, A / Engels, P / Drung, J / Pang, G / Kwong, M / Ellsmere, J / Chang, D / Hutter, M / Spence, R / Abou Khalil, M / Vasilevsky, C / Morin, N / Longtin, Y / Liberman, S / Montpetit, P / Poirier, M / Mukherjee, K / Sebajang, H / Younan, R / Schwenter, F / De Broux, E / Larsen, K / Beckett, A / Nantais, J / Kay, J / Lohre, R / Ayeni, O / Goel, D / de Sa, D / He, R / Hylton, D / Bedard, E / Johnson, S / Laing, B / Valji, A / Hanna, W / Turner, S / Akhtar-Danesh, G / Akhtar-Danesh, N / Shargall, Y / Gupta, V / Kidane, B / Limbachia, J / Sullivan, K / Farrokhyar, F / Leontiadis, G / Patel, Y / Churchill, I / Xie, F / Seely, A / Spicer, J / Yasufuku, K / Beauchamp, M / Wald, J / Mbuagbaw, L / Agzarian, J / Finley, C / Fahim, C / Abbas, M / Olaiya, O / Begum, H / Ednie, A / Palma, D / Warner, A / Malthaner, R / Fortin, D / Qiabi, M / Nayak, R / Nguyen, T / Louie, A / Rodrigues, G / Yaremko, B / Laba, J / Inculet, R / Alaichi, J / Mador, B / Lai, H / White, J / Kim, M / Darling, G / Rousseau, M / Samarasinghe, Y / Lee, M / Thiru, L / Levine, O / Juergens, R / Brogly, S / Li, W / Lougheed, D / Petsikas, D / Mistry, N / Gatti, A / Abdul, S / Anestee, C / Gilbert, S / Sundaresan, S / Villeneuve, P / Maziak, D / Razzak, R / Ashrafi, A / Tregobov, N / Hassanzadeh, N / Stone, S / Panjwani, A / Bong, T / Bond, R / Hafizi, A / De Meo, M / Rayes, R / Milette, S / Vagai, M / Usatii, M / Chandrasekaran, A / Giannias, B / Bourdeau, F / Sangwan, V / Bertos, N / Moraes, C / Huang, S / Quail, D / Walsh, L / Camilleri-Broet, S / Fiset, P / Bilgic, E / Quaiattini, A / Maurice-Ventouris, M / Najmeh, S / Esther, L / Lu, 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Ruxton, R / Manuel, P / Mohamed, F / Motamedi, M K / Serahati, S / Rajendran, L / Phang, T / Caminsky, N / Alavi, K / Paquette, I / MacLean, T / Wexner, S / Steele, S / Patel, S / Bordeianou, L / Sylla, P / Bayat, Z / Kennedy, E / Victor, C / Govindarajan, A / Liang, J / Roy, H / Baig, Z / Karimmudin, A / Gill, D / Ginther, N / Alrashid, F / Wiseman, V / Zhang, L / MacDonald, P / Merchant, S M / Wattie Barnett, K / Caycedo-Marulanda, A / Patel, S V / Harra, Z / Hegagi, M / Alghaithi, N / Papillon, E / Kasteel, N / Kaur, G / Bindra, S / Malhotra, A / Graham, C / MacLean, A / Beck, P / Jijon, H / Ferraz, J / Szwimer, R / Merchant, S / Kong, W / Gyawali, B / Hanna, T / Chung, W / Nanji, S / Booth, C / Li, V / Awan, A / Serrano, P / Jacobson, M / Chanco, M / Wen, V / Singh, N / Peiris, L / Pasieka, J / Ghatage, P / Buie, D / Bouchard-Fortier, A / Mack, L / Marini, W / Zheng, W / Swallow, C / Reedijk, M / DiPasquale, A / Prus-Czrnecka, Z / Delmar, L / Gagnon, N / Villiard, R / Martel, É / 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D / Retrouvey, H / Kerrebijn, I / Butler, K / O'Neill, A / Cil, T / Zhong, T / Hofer, S / McCready, D / Look Hong, N / Skipworth, J / Mah, A / Desai, S / Chung, S / Scudamore, C / Segedi, M / Vasilyeva, E / Li, J / Kim, P / Deprato, A / Dajani, K / Gilbert, R / Smoot, R / Tzeng, C / Rocha, F / Yohanathan, L / Cleary, S / Bertens, K / Reyna-Sepulveda, F / Badrudin, D / Gala-Lopez, B / Hanna, N / Wei, X / Kaliwal, Y / Wei, A / Henault, D / Barrette, B / Pelletier, S / Thebault, P / Beaudry-Simoneau, E / Rong, Z / Plasse, M / Dagenais, A Roy M / Létourneau, R / Lapointe, R / Vandenbroucke-Menu, F / Nguyen, B / Soucy, G / Turcotte, S / Lemke, M / Waugh, E / Quan, D / Skaro, A / Lund, M / Glinka, J / Jada, G / Daza, J / Msallak, H / Zhang, B / Workneh, A / Faisal, S / Faisal, R / Fabbro, M / Gu, C / Claassen, M / Sapisochin, G / Breadner, D / Welch, S / Webb, A / Lester, E / Shapiro, A / Eurich, D / Essaji, Y / Shrader, H / Nayyar, A / Suraju, M / Williams-Perez, S / Ear, P / Chan, C / 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    Canadian journal of surgery. Journal canadien de chirurgie

    2021  Band 64, Heft 6 Suppl 2, Seite(n) S80–S159

    Mesh-Begriff(e) Canada ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-12-15
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.021321
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 221: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

    Jayaraman, S / Lee, L / Mata, J / Droeser, R / Kaneva, P / Liberman, S / Charlebois, P / Stein, B / Fried, G / Feldman, L / Schellenberg, M / Inaba, K / Cheng, V / Bardes, J / Lam, L / Benjamin, E / Matsushima, K / Demetriades, D / Cho, J /
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    Canadian journal of surgery. Journal canadien de chirurgie

    2018  Band 61, Heft 4 Suppl 1, Seite(n) S94–S174

    Sprache Englisch
    Erscheinungsdatum 2018-08-01
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.010618
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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