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  1. AU="Dhingra, Simran"
  2. TI=Neutrophil to lymphocyte Ratio and Platelet to lymphocyte Ratio as Predictors of the Early Requirement of Mechanical Ventilation in COVID 19 Patients

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  1. Artikel ; Online: Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR).

    Kaufman, Nichole E M / Dhingra, Simran / Jois, Seetharama D / Vicente, Maria da Graça H

    Molecules (Basel, Switzerland)

    2021  Band 26, Heft 4

    Abstract: Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers. As a result, these receptor ... ...

    Abstract Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers. As a result, these receptor families constitute attractive targets for imaging and therapeutic applications in the detection and treatment of cancer. This review explores the dynamic structure and structure-function relationships of these two growth factor receptors and their significance as it relates to theranostics of cancer, followed by some of the common inhibition modalities frequently employed to target EGFR and VEGFR, such as tyrosine kinase inhibitors (TKIs), antibodies, nanobodies, and peptides. A summary of the recent advances in molecular imaging techniques, including positron emission tomography (PET), single-photon emission computerized tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI), and optical imaging (OI), and in particular, near-IR fluorescence imaging using tetrapyrrolic-based fluorophores, concludes this review.
    Mesh-Begriff(e) Animals ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Molecular Imaging ; Molecular Targeted Therapy ; Peptides/chemistry ; Peptides/pharmacology ; Protein Multimerization ; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors ; Receptors, Vascular Endothelial Growth Factor/chemistry ; Receptors, Vascular Endothelial Growth Factor/metabolism
    Chemische Substanzen Peptides ; ErbB Receptors (EC 2.7.10.1) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2021-02-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26041076
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  2. Artikel ; Online: A Comparison of the Photophysical, Electrochemical and Cytotoxic Properties of

    Ndung'u, Caroline / LaMaster, Daniel J / Dhingra, Simran / Mitchell, Nathan H / Bobadova-Parvanova, Petia / Fronczek, Frank R / Elgrishi, Noémie / Vicente, Maria da Graça H

    Sensors (Basel, Switzerland)

    2022  Band 22, Heft 14

    Abstract: Boron dipyrromethene (BODIPY) dyes bearing a pyridyl moiety have been used as metal ion sensors, pH sensors, fluorescence probes, and as sensitizers for phototherapy. A comparative study of the properties of the three structural isomers ... ...

    Abstract Boron dipyrromethene (BODIPY) dyes bearing a pyridyl moiety have been used as metal ion sensors, pH sensors, fluorescence probes, and as sensitizers for phototherapy. A comparative study of the properties of the three structural isomers of
    Mesh-Begriff(e) Boron Compounds/chemistry ; Boron Compounds/toxicity ; Humans ; Molecular Structure ; Solvents/chemistry ; Water
    Chemische Substanzen 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Boron Compounds ; Solvents ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2022-07-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22145121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant.

    Kaushik, Deepender / Dhingra, Simran / Patil, Madhuri T / Piplani, Sakshi / Khanna, Varun / Honda-Okubo, Yoshikazu / Li, Lei / Fung, Johnson / Sakala, Isaac G / Salunke, Deepak B / Petrovsky, Nikolai

    Human vaccines & immunotherapeutics

    2020  Band 16, Heft 8, Seite(n) 1989–1996

    Abstract: Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4- ...

    Abstract Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but has remained relatively unexplored because of its commercial unavailability. Indeed,
    Mesh-Begriff(e) Adjuvants, Immunologic ; Animals ; Imiquimod ; Influenza Vaccines ; Influenza, Human/prevention & control ; Mice ; Toll-Like Receptor 7
    Chemische Substanzen Adjuvants, Immunologic ; Influenza Vaccines ; Toll-Like Receptor 7 ; Imiquimod (P1QW714R7M)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2019.1710409
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6967: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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