Artikel ; Online: Late-stage functionalization of biologically active heterocycles through photoredox catalysis.
Angewandte Chemie (International ed. in English)
2014 Band 53, Heft 19, Seite(n) 4802–4806
Abstract: The direct CH functionalization of heterocycles has become an increasingly valuable tool in modern drug discovery. However, the introduction of small alkyl groups, such as methyl, by this method has not been realized in the context of complex molecule ... ...
| Abstract | The direct CH functionalization of heterocycles has become an increasingly valuable tool in modern drug discovery. However, the introduction of small alkyl groups, such as methyl, by this method has not been realized in the context of complex molecule synthesis since existing methods rely on the use of strong oxidants and elevated temperatures to generate the requisite radical species. Herein, we report the use of stable organic peroxides activated by visible-light photoredox catalysis to achieve the direct methyl-, ethyl-, and cyclopropylation of a variety of biologically active heterocycles. The simple protocol, mild reaction conditions, and unique tolerability of this method make it an important tool for drug discovery. |
|---|---|
| Mesh-Begriff(e) | Catalysis ; Heterocyclic Compounds/chemistry ; Oxidation-Reduction ; Photochemistry |
| Chemische Substanzen | Heterocyclic Compounds |
| Sprache | Englisch |
| Erscheinungsdatum | 2014-05-05 |
| Erscheinungsland | Germany |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2011836-3 |
| ISSN | 1521-3773 ; 1433-7851 |
| ISSN (online) | 1521-3773 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.201402023 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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