Treffer 1 - 7 von insgesamt 7
2018
| Verfasserangabe | Bilal Djeghout |
|---|---|
| Sprache | Englisch |
| Umfang | Online-Ressource |
| Dokumenttyp | Buch ; Online |
| Datenquelle | Bibliothek der Tierärztlichen Hochschule Hannover |
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Journal of infection in developing countries
2018 Band 12, Heft 4, Seite(n) 244–249
Abstract: Introduction: The frequency of Enterobacteriaceae involved in urinary tract infections (UTI) has increased significantly since the early 1990s, particularly in at-risk facilities such as resuscitation, surgery, urology and nephrology. The objective of ... ...
| Abstract | Introduction: The frequency of Enterobacteriaceae involved in urinary tract infections (UTI) has increased significantly since the early 1990s, particularly in at-risk facilities such as resuscitation, surgery, urology and nephrology. The objective of this study was to evaluate the antimicrobial susceptibility of Enterobacteriaceae causing urinary tract infections (UTIs)at the University Hospital Centre of Benimessous in Algiers. Methodology: The study was designed as a retrospective study (between January 1st 2010 and December 31st 2012) and a prospective study (between January 1standApril 30th 2013) on 13,611 urine samples. Antimicrobial resistance phenotyping was conducted on the bacterial isolates using disk-diffusion method. Results: On 13,611 urine samples analysed, 1,790 (13.15%) fulfilled the criteria for urinary tract infection. Enterobacteriaceae were identified in 1,561 analysed samples (87%). Escherichia coli was the dominant uropathogen (66,15%) in both hospitalized and non-hospitalized patients. The other main detected Enterobacteriaceae members were Klebsiella pneumoniae (11,96%) and Proteus mirabilis (5,42%). Analysis of results showed also that women were more prone to UTI than men with sex ratio of 3.76(W/M). The susceptibilities of isolated Enterobacteriaceae to antibiotics revealed that they had acquired resistance to several classes, particularly toward β-lactams. Resistance frequencies were relatively high to ampicillin and sulfomethoxasole, while being very low to aminoglycosides and furans. Results obtained revealed also that 7% of isolates where resistant to third generation cephalosporins by production of extended spectrum β-lactamases (ESBL). Conclusions: The continuous monitoring of antibiotic resistance of uropathogenic Escherichia coli is crucial to guide the clinician to choose the best empiric treatment. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2018-04-30 |
| Erscheinungsland | Italy |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2394024-4 |
| ISSN | 1972-2680 ; 2036-6590 |
| ISSN (online) | 1972-2680 |
| ISSN | 2036-6590 |
| DOI | 10.3855/jidc.10017 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Band 14, Heft 1, Seite(n) 45
Abstract: Background: Campylobacter jejuni is a pervasive pathogen of major public health concern with a complex ecology requiring accurate and informative approaches to define pathogen diversity during outbreak investigations. Source attribution analysis may be ... ...
| Abstract | Background: Campylobacter jejuni is a pervasive pathogen of major public health concern with a complex ecology requiring accurate and informative approaches to define pathogen diversity during outbreak investigations. Source attribution analysis may be confounded if the genetic diversity of a C. jejuni population is not adequately captured in a single specimen. The aim of this study was to determine the genomic diversity of C. jejuni within individual stool specimens from four campylobacteriosis patients. Direct plating and pre-culture filtration of one stool specimen per patient was used to culture multiple isolates per stool specimen. Whole genome sequencing and pangenome level analysis were used to investigate genomic diversity of C. jejuni within a patient. Results: A total 92 C. jejuni isolates were recovered from four patients presenting with gastroenteritis. The number of isolates ranged from 13 to 30 per patient stool. Three patients yielded a single C. jejuni multilocus sequence type: ST-21 (n = 26, patient 4), ST-61 (n = 30, patient 1) and ST-2066 (n = 23, patient 2). Patient 3 was infected with two different sequence types [ST-51 (n = 12) and ST-354 (n = 1)]. Isolates belonging to the same sequence type from the same patient specimen shared 12-43 core non-recombinant SNPs and 0-20 frameshifts with each other, and the pangenomes of each sequence type consisted of 1406-1491 core genes and 231-264 accessory genes. However, neither the mutation nor the accessory genes were connected to a specific functional gene category. Conclusions: Our findings show that the C. jejuni population recovered from an individual patient's stool are genetically diverse even within the same ST and may have shared common ancestors before specimens were obtained. The population is unlikely to have evolved from a single isolate at the time point of initial patient infection, leading us to conclude that patients were likely infected with a heterogeneous C. jejuni population. The diversity of the C. jejuni population found within individual stool specimens can inform future methodological approaches to attribution and outbreak investigations. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-12-07 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2478277-4 |
| ISSN | 1757-4749 |
| ISSN | 1757-4749 |
| DOI | 10.1186/s13099-022-00520-1 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Band 11, Seite(n) 1072
Abstract: Campylobacter ... ...
| Abstract | Campylobacter jejuni |
|---|---|
| Sprache | Englisch |
| Erscheinungsdatum | 2020-06-19 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2587354-4 |
| ISSN | 1664-302X |
| ISSN | 1664-302X |
| DOI | 10.3389/fmicb.2020.01072 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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The International journal of developmental biology
2021 Band 65, Heft 7-8-9, Seite(n) 487–496
Abstract: The timing of the M-phase is precisely controlled by a CDC6-dependent mechanism inhibiting the mitotic histone H1 kinase. Here, we describe the differential regulation of the dynamics of this mitotic kinase activity by exogenous cyclin A or cyclin B in ... ...
| Abstract | The timing of the M-phase is precisely controlled by a CDC6-dependent mechanism inhibiting the mitotic histone H1 kinase. Here, we describe the differential regulation of the dynamics of this mitotic kinase activity by exogenous cyclin A or cyclin B in the |
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| Mesh-Begriff(e) | Animals ; Cell Cycle Proteins/metabolism ; Cell Extracts ; Cyclin A ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinases/metabolism ; Cyclins/metabolism ; Mitosis ; Phosphorylation ; Xenopus Proteins/metabolism ; Xenopus laevis/metabolism |
| Chemische Substanzen | Cell Cycle Proteins ; Cell Extracts ; Cyclin A ; Cyclins ; Xenopus Proteins ; Xicl protein, Xenopus ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Cyclin-Dependent Kinases (EC 2.7.11.22) |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-09-22 |
| Erscheinungsland | Spain |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1036070-0 |
| ISSN | 1696-3547 ; 0214-6282 |
| ISSN (online) | 1696-3547 |
| ISSN | 0214-6282 |
| DOI | 10.1387/ijdb.200313jk |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3202: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Journal of infection in developing countries
2017 Band 11, Heft 8, Seite(n) 583–590
Abstract: Non-typhoidal Salmonella (NTS) represents a leading cause of food-borne disease worldwide. It is a global public health concern: more than 94 million cases and 115,000 deaths are reported every year, with a disproportionate impact in developing countries. ...
| Abstract | Non-typhoidal Salmonella (NTS) represents a leading cause of food-borne disease worldwide. It is a global public health concern: more than 94 million cases and 115,000 deaths are reported every year, with a disproportionate impact in developing countries. The prevalence of multi-drug-resistant (MDR) Salmonella strains is another major health concern which affects antimicrobial treatment, as many studies report that infections caused by MDR strains are more severe than those caused by susceptible strains. In Algeria, NTS represent one of the primary causes of salmonellosis in both humans and food animal production, especially poultry. Epidemiological surveillance systems and monitoring programs for Salmonella infections are essential requirements to provide data useful for the effective detection and control of Salmonella outbreaks. The present review will supply a perspective on NTS infection, pathogenesis and antimicrobial resistance with a focus on the epidemiology of salmonellosis in Algeria. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2017-09-05 |
| Erscheinungsland | Italy |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2394024-4 |
| ISSN | 1972-2680 ; 2036-6590 |
| ISSN (online) | 1972-2680 |
| ISSN | 2036-6590 |
| DOI | 10.3855/jidc.9456 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Journal of medical microbiology
2018 Band 67, Heft 5, Seite(n) 620–627
Abstract: Purpose: Ceftriaxone is the drug of choice for typhoid fever and the emergence of resistant Salmonella Typhi raises major concerns for treatment. There are an increasing number of sporadic reports of ceftriaxone-resistant S. Typhi and limiting the risk ... ...
| Abstract | Purpose: Ceftriaxone is the drug of choice for typhoid fever and the emergence of resistant Salmonella Typhi raises major concerns for treatment. There are an increasing number of sporadic reports of ceftriaxone-resistant S. Typhi and limiting the risk of treatment failure in the patient and outbreaks in the community must be prioritized. This study describes the use of whole genome sequencing to guide outbreak identification and case management. Methodology: An isolate of ceftriaxone-resistant S. Typhi from the blood of a child taken in 2000 at the Popular Diagnostic Center, Dhaka, Bangladesh was subjected to whole genome sequencing, using an Illumina NextSeq 500 and analysis using Geneious software.Results/Key findings. Comparison with other ceftriaxone-resistant S. Typhi revealed an isolate from the Democratic Republic of the Congo in 2015 as the closest relative but no evidence of an outbreak. A plasmid belonging to incompatibility group I1 (IncI1-ST31) which included blaCTX-M-15 (ceftriaxone resistance) associated with ISEcp-1 was identified. High similarity (90 %) was seen with pS115, an IncI1 plasmid from S. Enteritidis, and with pESBL-EA11, an incI1 plasmid from E. coli (99 %) showing that S. Typhi has access to ceftriaxone resistance through the acquisition of common plasmids. Conclusions: The transmission of ceftriaxone resistance from E. coli to S. Typhi is of concern because of clinical resistance to ceftriaxone, the main stay of typhoid treatment. Whole genome sequencing, albeit several years after the isolation, demonstrated the success of containment but clinical trials with alternative agents are urgently required. |
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| Mesh-Begriff(e) | Anti-Bacterial Agents/pharmacology ; Ceftriaxone/pharmacology ; Cephalosporin Resistance/genetics ; Child ; Disease Outbreaks ; Drug Resistance, Bacterial/genetics ; Humans ; Phylogeny ; Plasmids/genetics ; Salmonella typhi/drug effects ; Salmonella typhi/enzymology ; Salmonella typhi/genetics ; Salmonella typhi/isolation & purification ; Typhoid Fever/microbiology ; Whole Genome Sequencing ; beta-Lactamases/genetics |
| Chemische Substanzen | Anti-Bacterial Agents ; Ceftriaxone (75J73V1629) ; beta-lactamase CTX-M-15 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6) |
| Sprache | Englisch |
| Erscheinungsdatum | 2018-04-04 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 218356-0 |
| ISSN | 1473-5644 ; 0022-2615 |
| ISSN (online) | 1473-5644 |
| ISSN | 0022-2615 |
| DOI | 10.1099/jmm.0.000727 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 634: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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