Artikel ; Online: Measuring clinical outcomes in children with pediatric acute-onset neuropsychiatric syndrome: data from a 2-5 year follow-up study.
BMC psychiatry
2021 Band 21, Heft 1, Seite(n) 484
Abstract: Background: It is unclear how to best measure the complex symptom presentation of pediatric acute-onset neuropsychiatric syndrome (PANS).: Methods: Well-characterized participants of a 2-5 year follow-up study (n = 34; 56% male) underwent clinical ... ...
Abstract | Background: It is unclear how to best measure the complex symptom presentation of pediatric acute-onset neuropsychiatric syndrome (PANS). Methods: Well-characterized participants of a 2-5 year follow-up study (n = 34; 56% male) underwent clinical evaluations and completed scales assessing global symptom severity, functional impairment and specific psychiatric symptoms. We explored inter-correlations between the measures and used intraclass correlation coefficients to evaluate the agreement between clinician-, parent- and child ratings of the same constructs. Results: Ratings on symptom-specific measures varied largely between participants. Agreement between informants was excellent on functional scales, fair-to-moderate on global severity scales and mixed on symptom-specific scales. Clinician-rated global and functional measures had stronger inter-correlations with parent- and child-rated functional measures than with symptom-specific measures. Conclusions: General instruments assessing global severity and functioning are well suited for the assessment and follow-up of PANS, but should be complemented by symptom-specific scales representative of core symptoms. |
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Mesh-Begriff(e) | Autoimmune Diseases ; Female ; Follow-Up Studies ; Humans ; Male ; Obsessive-Compulsive Disorder ; Streptococcal Infections |
Sprache | Englisch |
Erscheinungsdatum | 2021-10-04 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 1471-244X |
ISSN (online) | 1471-244X |
DOI | 10.1186/s12888-021-03450-5 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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