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  1. Artikel ; Online: Investigating the Effects of Diet-Induced Prediabetes on Skeletal Muscle Strength in Male Sprague Dawley Rats.

    Dlamini, Mandlakazi / Khathi, Andile

    International journal of molecular sciences

    2024  Band 25, Heft 7

    Abstract: Type 2 diabetes mellitus, a condition preceded by prediabetes, is documented to compromise skeletal muscle health, consequently affecting skeletal muscle structure, strength, and glucose homeostasis. A disturbance in skeletal muscle functional capacity ... ...

    Abstract Type 2 diabetes mellitus, a condition preceded by prediabetes, is documented to compromise skeletal muscle health, consequently affecting skeletal muscle structure, strength, and glucose homeostasis. A disturbance in skeletal muscle functional capacity has been demonstrated to induce insulin resistance and hyperglycemia. However, the modifications in skeletal muscle function in the prediabetic state are not well elucidated. Hence, this study investigated the effects of diet-induced prediabetes on skeletal muscle strength in a prediabetic model. Male Sprague Dawley rats were randomly assigned to one of the two groups (
    Mesh-Begriff(e) Male ; Rats ; Animals ; Rats, Sprague-Dawley ; Prediabetic State/etiology ; Insulin Resistance ; Blood Glucose ; Diabetes Mellitus, Type 2/etiology ; Glycated Hemoglobin ; Diet/adverse effects ; Muscle, Skeletal ; Insulin ; Insulin, Regular, Human ; Hyperglycemia
    Chemische Substanzen Blood Glucose ; Glycated Hemoglobin ; Insulin ; Insulin, Regular, Human
    Sprache Englisch
    Erscheinungsdatum 2024-04-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074076
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review.

    Dlamini, Mandlakazi / Khathi, Andile

    International journal of molecular sciences

    2023  Band 25, Heft 1

    Abstract: The skeletal muscle plays a critical role in regulating systemic blood glucose homeostasis. Impaired skeletal muscle glucose homeostasis associated with type 2 diabetes mellitus (T2DM) has been observed to significantly affect the whole-body glucose ... ...

    Abstract The skeletal muscle plays a critical role in regulating systemic blood glucose homeostasis. Impaired skeletal muscle glucose homeostasis associated with type 2 diabetes mellitus (T2DM) has been observed to significantly affect the whole-body glucose homeostasis, thereby resulting in other diabetic complications. T2DM does not only affect skeletal muscle glucose homeostasis, but it also affects skeletal muscle structure and functional capacity. Given that T2DM is a global health burden, there is an urgent need to develop therapeutic medical therapies that will aid in the management of T2DM. Prediabetes (PreDM) is a prominent risk factor of T2DM that usually goes unnoticed in many individuals as it is an asymptomatic condition. Hence, research on PreDM is essential because establishing diabetic biomarkers during the prediabetic state would aid in preventing the development of T2DM, as PreDM is a reversible condition if it is detected in the early stages. The literature predominantly documents the changes in skeletal muscle during T2DM, but the changes in skeletal muscle during prediabetes are not well elucidated. In this review, we seek to review the existing literature on PreDM- and T2DM-associated changes in skeletal muscle function.
    Mesh-Begriff(e) Humans ; Prediabetic State ; Diabetes Mellitus, Type 2 ; Muscle, Skeletal ; Musculoskeletal Physiological Phenomena ; Blood Glucose
    Chemische Substanzen Blood Glucose
    Sprache Englisch
    Erscheinungsdatum 2023-12-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010469
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Entrepreneurial intention and the three stages of entrepreneurial action: a process approach.

    Dlamini, Mzwakhe / Botha, Melodi

    Frontiers in psychology

    2023  Band 14, Seite(n) 1184390

    Abstract: The relationship between entrepreneurial intention (EI) and entrepreneurial action (EA) is a popular topic in entrepreneurship research, owing to the contribution of these constructs in the process leading to the entrepreneurial activity taking place. ... ...

    Abstract The relationship between entrepreneurial intention (EI) and entrepreneurial action (EA) is a popular topic in entrepreneurship research, owing to the contribution of these constructs in the process leading to the entrepreneurial activity taking place. There are still countries that are recording high entrepreneurial intention levels in comparison to their corresponding entrepreneurial action levels that are low. This is a global concern to which South Africa (SA) is also not immune. Most of the research tests the relationship between two single constructs: EI and EA. Our study follows a process approach and investigates the effect of this relationship between EI and the three stages of EA. A quantitative method was employed and a survey utilized whereby data was collected among 597 entrepreneurs in South Africa. The data was analyzed through Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM). The EI construct is supported through the Theory of Planned Behavior, in conjunction with the Motivation Opportunity Ability theory. The Discovery Theory, together with the Creative Theory, supports each of the stages of EA, namely: entrepreneurial opportunity discovery (EODI); entrepreneurial opportunity evaluation (EOEV); and entrepreneurial opportunity exploitation (EOEX). Previous research regarding the relationship between EI and EA measured this relationship from a binary point of view. This study contributes to the entrepreneurship field by employing the process approach to determine the impact of EI on the stages of EA. This study reveals that EI is statistically significant in all three stages of EA. However, the strength of this relationship is found to be strong between EI and the EODI and EOEV stages and moderate between EI and the EOEX stage. Therefore, this study reveals that effective training interventions and development are necessary between EI and the EOEX stage of EA.
    Sprache Englisch
    Erscheinungsdatum 2023-07-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1184390
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A systematic review on the incidence of influenza viruses in wastewater matrices: Implications for public health.

    Dlamini, Mbasa / Msolo, Luyanda / Ehi Ebomah, Kingsley / Nontongana, Nolonwabo / Ifeanyi Okoh, Anthony

    PloS one

    2024  Band 19, Heft 4, Seite(n) e0291900

    Abstract: Influenza viruses pose a significant public health threat, necessitating comprehensive surveillance strategies to enhance early detection and preventive measures. This systematic review investigates the incidence of influenza viruses in wastewater ... ...

    Abstract Influenza viruses pose a significant public health threat, necessitating comprehensive surveillance strategies to enhance early detection and preventive measures. This systematic review investigates the incidence of influenza viruses in wastewater matrices, aiming to elucidate the potential implications for public health. The study synthesizes existing literature, employing rigorous inclusion criteria to identify relevant studies conducted globally. The essence of the problem lies in the gaps of traditional surveillance methods, which often rely on clinical data and may underestimate the true prevalence of influenza within communities. Wastewater-based epidemiology offers a novel approach to supplementing these conventional methods, providing a broader and more representative assessment of viral circulation. This review systematically examines the methodologies employed in the selected studies, including virus concentration techniques and molecular detection methods, to establish a standardized framework for future research. Our findings reveal a consistent presence of influenza viruses in diverse wastewater matrices across different geographic locations and seasons. Recommendations for future research include the standardization of sampling protocols, improvement of virus concentration methods, and the integration of wastewater surveillance into existing public health frameworks. In conclusion, this systematic review contributes to the understanding of influenza dynamics in wastewater matrices, offering valuable insights for public health practitioners and policymakers. Implementation of wastewater surveillance alongside traditional methods can enhance the resilience of public health systems and better prepare communities for the challenges posed by influenza outbreaks.
    Mesh-Begriff(e) Wastewater/virology ; Humans ; Public Health ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Incidence ; Orthomyxoviridae/isolation & purification
    Chemische Substanzen Wastewater
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291900
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Screening of

    Elaine Mankge, Malese / Penistacia Maela, Mehabo / Mark Abrahams, Adrian / Hope Serepa-Dlamini, Mahloro

    Heliyon

    2024  Band 10, Heft 9, Seite(n) e30736

    Abstract: Research on proteases and secondary metabolites from endophytes is an area that requires attention from researchers. In this study, proteases ... ...

    Abstract Research on proteases and secondary metabolites from endophytes is an area that requires attention from researchers. In this study, proteases from
    Sprache Englisch
    Erscheinungsdatum 2024-05-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e30736
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Assessing the Effects of Land Use on Surface Water Quality in the Lower uMfolozi Floodplain System, South Africa.

    Dlamini, Mandla / Chirima, George / Jovanovic, Nebo / Adam, Elhadi

    International journal of environmental research and public health

    2021  Band 18, Heft 2

    Abstract: This study investigated the impacts of cultivation on water and soil quality in the lower uMfolozi floodplain system in KwaZulu-Natal province, South Africa. We did this by assessing seasonal variations in purposefully selected water and soil properties ... ...

    Abstract This study investigated the impacts of cultivation on water and soil quality in the lower uMfolozi floodplain system in KwaZulu-Natal province, South Africa. We did this by assessing seasonal variations in purposefully selected water and soil properties in these two land-use systems. The observed values were statistically analysed by performing Student's paired
    Mesh-Begriff(e) Agriculture ; Environmental Monitoring ; Humans ; Sodium/analysis ; Soil ; South Africa ; Water Quality
    Chemische Substanzen Soil ; Sodium (9NEZ333N27)
    Sprache Englisch
    Erscheinungsdatum 2021-01-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18020561
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Combinatorial nanodot stripe assay to systematically study cell haptotaxis.

    Dlamini, Mcolisi / Kennedy, Timothy E / Juncker, David

    Microsystems & nanoengineering

    2020  Band 6, Seite(n) 114

    Abstract: Haptotaxis is critical to cell guidance and development and has been studied in vitro using either gradients or stripe assays that present a binary choice between full and zero coverage of a protein cue. However, stripes offer only a choice between ... ...

    Abstract Haptotaxis is critical to cell guidance and development and has been studied in vitro using either gradients or stripe assays that present a binary choice between full and zero coverage of a protein cue. However, stripes offer only a choice between extremes, while for gradients, cell receptor saturation, migration history, and directional persistence confound the interpretation of cellular responses. Here, we introduce nanodot stripe assays (NSAs) formed by adjacent stripes of nanodot arrays with different surface coverage. Twenty-one pairwise combinations were designed using 0, 1, 3, 10, 30, 44 and 100% stripes and were patterned with 200 × 200, 400 × 400 or 800 × 800 nm
    Sprache Englisch
    Erscheinungsdatum 2020-12-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2055-7434
    ISSN (online) 2055-7434
    DOI 10.1038/s41378-020-00223-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Characterizing Leaf Nutrients of Wetland Plants and Agricultural Crops with Nonparametric Approach Using Sentinel-2 Imagery Data

    Dlamini, Mandla / Chirima, George / Sibanda, Mbulisi / Adam, Elhadi / Dube, Timothy

    Remote Sensing. 2021 Oct. 22, v. 13, no. 21

    2021  

    Abstract: In arid environments of the world, particularly in sub-Saharan Africa and Asia, floodplain wetlands are a valuable agricultural resource. However, the water reticulation role by wetlands and crop production can negatively impact wetland plants. Knowledge ...

    Abstract In arid environments of the world, particularly in sub-Saharan Africa and Asia, floodplain wetlands are a valuable agricultural resource. However, the water reticulation role by wetlands and crop production can negatively impact wetland plants. Knowledge on the foliar biochemical elements of wetland plants enhances understanding of the impacts of agricultural practices in wetlands. This study thus used Sentinel-2 multispectral data to predict seasonal variations in the concentrations of nine foliar biochemical elements in plant leaves of key floodplain wetland vegetation types and crops in the uMfolozi floodplain system (UFS). Nutrient concentrations in different floodplain plant species were estimated using Sentinel-2 multispectral data derived vegetation indices in concert with the random forest regression. The results showed a mean R² of 0.87 and 0.86 for the dry winter and wet summer seasons, respectively. However, copper, sulphur, and magnesium were poorly correlated (R² ≤ 0.5) with vegetation indices during the summer season. The average % relative root mean square errors (RMSE’s) for seasonal nutrient estimation accuracies for crops and wetland vegetation were 15.2 % and 26.8%, respectively. There was a significant difference in nutrient concentrations between the two plant types, (R² = 0.94 (crops), R² = 0.84 (vegetation). The red-edge position 1 (REP1) and the normalised difference vegetation index (NDVI) were the best nutrient predictors. These results demonstrate the usefulness of Sentinel-2 imagery and random forests regression in predicting seasonal, nutrient concentrations as well as the accumulation of chemicals in wetland vegetation and crops.
    Schlagwörter algorithms ; copper ; crop production ; floodplains ; leaves ; magnesium ; normalized difference vegetation index ; sulfur ; summer ; wetlands ; winter ; Asia ; Sub-Saharan Africa
    Sprache Englisch
    Erscheinungsverlauf 2021-1022
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs13214249
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: TB testing in HIV-positive patients prior to antiretroviral treatment.

    Spooner, E / Reddy, S / Ntoyanto, S / Sakadavan, Y / Reddy, T / Mahomed, S / Mlisana, K / Dlamini, M / Daniels, B / Luthuli, N / Ngomane, N / Kiepiela, P / Coutsoudis, A

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2022  Band 26, Heft 3, Seite(n) 224–231

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    Mesh-Begriff(e) Humans ; Anti-Retroviral Agents ; HIV Infections/complications ; HIV Infections/drug therapy ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Sensitivity and Specificity ; Sputum ; Tuberculosis/diagnosis
    Chemische Substanzen Anti-Retroviral Agents
    Sprache Englisch
    Erscheinungsdatum 2022-02-22
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.21.0195
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4776: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 261: Hefte anzeigen

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  10. Artikel ; Online: Girl Champ in eSwatini: A Strategic Marketing Campaign to Promote Demand for Sexual and Reproductive Health Services Among Young Women.

    Brault, Marie A / Christie, Sarah / Manchia, Amanda / Mabuza, Khabonina / Dlamini, Muhle / Linnander, Erika L

    AIDS and behavior

    2021  Band 26, Heft 3, Seite(n) 853–863

    Abstract: Efforts to engage adolescent girls and young women (AGYW) in HIV services have struggled, in part, due to limited awareness of services and stigma. Strategic marketing is a promising approach, but the impact on youth behavior change is unclear. We report ...

    Abstract Efforts to engage adolescent girls and young women (AGYW) in HIV services have struggled, in part, due to limited awareness of services and stigma. Strategic marketing is a promising approach, but the impact on youth behavior change is unclear. We report findings from a mixed methods evaluation of the Girl Champ campaign, designed to generate demand for sexual and reproductive services among AGYW, and piloted in three clinics in the Manzini region of eSwatini. We analyzed and integrated data from longitudinal, clinic-level databases on health service utilization among AGYW before and after the pilot, qualitative interviews with stakeholders responsible for the implementation of the pilot, and participant feedback surveys from attendees of Girl Champ events. Girl Champ was well received by most stakeholders based on event attendance and participant feedback, and associated with longitudinal improvements in demand for HIV services. Findings can inform future HIV demand creation interventions for youth.
    Mesh-Begriff(e) Adolescent ; Eswatini ; Female ; HIV Infections/prevention & control ; Humans ; Marketing ; Reproductive Health ; Reproductive Health Services ; Sexual Behavior
    Sprache Englisch
    Erscheinungsdatum 2021-08-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-021-03446-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6451: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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